The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Dual Repression by Fe 2+ -Fur and Mn 2+ -MntR of the mntH Gene, Encoding an NRAMP-Like Mn 2+ Transporter in Escherichia coli
Open accessAbstract
The uptake of Mn 2+ , a cofactor for several enzymes in Escherichia coli , is mediated by MntH, a proton-dependent metal transporter, which also recognizes Fe 2+ with lower affinity. MntH belongs to the NRAMP family of eukaryotic Fe 2+ and Mn 2+ transporters. In E. coli strains with chromosomal mntH-lacZ fusions, mntH was partially repressed by both Mn 2+ and Fe 2+ . Inactivation of fur resulted in the loss of Fe 2+ -dependent repression of mntH transcription, demonstrating that Fe 2+ repression depends on the global iron regulator Fur. However, these fur mutants still showed Mn 2+ -dependent repression of mntH . The Mn 2+ -responsive transcriptional regulator of mntH was identified as the gene product of o155 (renamed MntR). mntR mutants were impaired in Mn 2+ but not Fe 2+ repression of mntH transcription. Binding of purified MntR to the mntH operator was manganese dependent. The binding region was localized by DNase I footprinting analysis and covers a nearly perfect palindrome. The Fur binding site, localized within 22 nucleotides of the mntH operator by in vivo operator titration assays, resembles the Fur-box consensus sequence.
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Cites
de Lorenzo, V, Wee, S., Herrero, M., & Neilands, J. B. (1987) · Journal of Bacteriology · doi:10.1128/jb.169.6.2624-2630.1987 · Cited by 536 · cited 2×
“The binding site GAgAATG ATtATCAaatTC matches the Fur-box consensus sequence GATAATGATAATCATTATC (9) in 14 of 19 nt (mismatches are shown as lowercase letters).”
BackgroundThe ZnuABC high‐affinity zinc uptake system and its regulator Zur in Escherichia coli
Patzer, S. I., & Hantke, K. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.00883.x · Cited by 490 · cited 3×
“In addition to the iron regulator Fur, the Fur family includes the regulator of Zn(21) transport, Zur (8, 11, 21), and the regulator of the peroxide stress response, PerR (4).”
BackgroundSelf-citationKehres, D. G., Zaharik, M. L., Finlay, B. B., & Maguire, M. E. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01922.x · Cited by 292
Que, Q., & Helmann, J. D. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01811.x · Cited by 282
Structure of the metal-ion-activated diphtheria toxin repressor/ tox operator complex
White, A., Ding, X., vanderSpek, J. C., Murphy, J. R., & Ringe, D. (1998) · Nature · doi:10.1038/28893 · Cited by 180
Cited by
Andrews, S. C., Robinson, A. K., & Rodríguez-Quiñones, F. (2003) · FEMS Microbiology Reviews · doi:10.1016/s0168-6445(03)00055-x · Cited by 2,702
Metal homeostasis and resistance in bacteria
Chandrangsu, P., Rensing, C., & Helmann, J. D. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.15 · Cited by 812
Transcriptional regulation by Ferric Uptake Regulator (Fur) in pathogenic bacteria
Troxell, B., & Hassan, H. M. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00059 · Cited by 500
Why do bacteria use so many enzymes to scavenge hydrogen peroxide?
Mishra, S., & Imlay, J. (2012) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2012.04.014 · Cited by 411
Porcheron, G., Garénaux, A., Proulx, J., Sabri, M., & Dozois, C. M. (2013) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2013.00090 · Cited by 366
Metadata
- Authors
- Patzer, S. I., & Hantke, K.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2001-08-15
- Volume
- 183
- Issue
- 16
- Pages
- 4806-4813
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2072058887
- Cited by
- 161
- References
- 5
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Dual Repression by Fe 2+ -Fur and Mn 2+ -MntR of the mntH Gene, Encoding an NRAMP-Like Mn 2+ Transporter in Escherichia coli. https://app.cochat.ai/papers/10.1128/jb.183.16.4806-4813.2001
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- Patzer, S. I., & Hantke, K. (2001). Dual Repression by Fe 2+ -Fur and Mn 2+ -MntR of the mntH Gene, Encoding an NRAMP-Like Mn 2+ Transporter in Escherichia coli. Journal of Bacteriology. https://doi.org/10.1128/jb.183.16.4806-4813.2001
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