The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Quorum Sensing Regulates Type III Secretion in Vibrio harveyi and Vibrio parahaemolyticus
Open accessAbstract
In a process known as quorum sensing, bacteria communicate with one another by producing, releasing, detecting, and responding to signal molecules called autoinducers.Vibrio harveyi, a marine pathogen, uses two parallel quorum-sensing circuits, each consisting of an autoinducer-sensor pair, to control the expression of genes required for bioluminescence and a number of other target genes. Genetic screens designed to discover autoinducer-regulated targets in V. harveyi have revealed genes encoding components of a putative type III secretion (TTS) system. Using transcriptional reporter fusions and TTS protein localization studies, we show that the TTS system is indeed functional in V. harveyi and that expression of the genes encoding the secretion machinery requires an intact quorum-sensing signal transduction cascade. The newly completed genome of the closely related marine bacterium Vibrio parahaemolyticus, which is a human pathogen, shows that it possesses the genes encoding both of the V. harveyi-like quorum-sensing signaling circuits and that it also has a TTS system similar to that of V. harveyi. We show that quorum sensing regulates TTS in V. parahaemolyticus. Previous reports connecting quorum sensing to TTS in enterohemorrhagic and enteropathogenic Escherichia coli show that quorum sensing activates TTS at high cell density. Surprisingly, we find that at high cell density (in the presence of autoinducers), quorum sensing represses TTS in V. harveyi and V. parahaemolyticus.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Molecular Cloning: A Laboratory Manual
Sambrook, J., Fritsch, E., & Maniatis, T. (1989) · UCLA - Biblioteca de Ciencias de la Salud · Cited by 133,589
Yanisch-Perron, C., Vieira, J., & Messing, J. (1985) · Gene · doi:10.1016/0378-1119(85)90120-9 · Cited by 15,041
Miller, M. B., & Bassler, B. L. (2001) · Annual Review of Microbiology · doi:10.1146/annurev.micro.55.1.165 · Cited by 5,105
Self-citationConstruction and characterization of new cloning vehicles. II. A multipurpose cloning system. 1977.
Bolívar, F. G., Rl, R., Pj, G., Betlach, M. C., Hl, H., Boyer, H. W., Crosa, J. H., & Falkow, S. (1992) · PubMed · Cited by 4,672
Construction and characterization of new cloning vehicle. II. A multipurpose cloning system
Bolivar, F., Rodriguez, R. L., Greene, P. J., Betlach, M. C., Heyneker, H. L., Boyer, H. W., Crosa, J. H., & Falkow, S. (1977) · Gene · doi:10.1016/0378-1119(77)90000-2 · Cited by 3,858
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system.
Bolivar, F., Rodriguez, R. L., Greene, P. J., Betlach, M. C., Heyneker, H. L., Boyer, H. W., Crosa, J. H., & Falkow, S. (1977) · PubMed · Cited by 2,750
Ditta, G., Stanfield, S., Corbin, D., & Helinski, D. R. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.12.7347 · Cited by 2,667
Type III Protein Secretion Systems in Bacterial Pathogens of Animals and Plants
Hueck, C. J. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.2.379-433.1998 · Cited by 2,394
Structural identification of a bacterial quorum-sensing signal containing boron
Chen, X., Schauder, S., Potier, N., Van Dorsselaer, A., Pelczer, I., Bassler, B. L., & Hughson, F. M. (2002) · Nature · doi:10.1038/415545a · Cited by 1,571
Self-citationGenome sequence of Yersinia pestis, the causative agent of plague
Parkhill, J., Wren, B. W., Thomson, N. R., Titball, R. W., Holden, M. T. G., Prentice, M. B., Sebaihia, M., James, K. D., Churcher, C., Mungall, K. L., et al. (2001) · Nature · doi:10.1038/35097083 · Cited by 1,243
Cited by
Thompson, F. L., Iida, T., & Swings, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.403-431.2004 · Cited by 1,240
Quorum sensing and social networking in the microbial world
Atkinson, S., & Williams, P. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0203 · Cited by 422
Vikram, A., Jayaprakasha, G. K., Jesudhasan, P. R., Pillai, S. D., & Patil, B. S. (2010) · Journal of Applied Microbiology · doi:10.1111/j.1365-2672.2010.04677.x · Cited by 393
Mini-review: quorum sensing in the marine environment and its relationship to biofouling
Dobretsov, S., Teplitski, M., & Paul, V. (2009) · Biofouling · doi:10.1080/08927010902853516 · Cited by 388
Defoirdt, T., Boon, N., Sorgeloos, P., Verstraete, W., & Bossier, P. (2007) · Trends in Biotechnology · doi:10.1016/j.tibtech.2007.08.001 · Cited by 379
Metadata
- Authors
- Henke, J. M., & Bassler, B. L.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2004-06-15
- Volume
- 186
- Issue
- 12
- Pages
- 3794-3805
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2118742923
- Cited by
- 332
- References
- 49
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Quorum Sensing Regulates Type III Secretion in Vibrio harveyi and Vibrio parahaemolyticus. https://app.cochat.ai/papers/10.1128/jb.186.12.3794-3805.2004
- The paper
- Henke, J. M., & Bassler, B. L. (2004). Quorum Sensing Regulates Type III Secretion in Vibrio harveyi and Vibrio parahaemolyticus. Journal of Bacteriology. https://doi.org/10.1128/jb.186.12.3794-3805.2004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
