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Mutations in PA2491 ( mexS ) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa
Open accessAbstract
Disruption of the PA2491 gene in a mini-Tn 5 - tet insertion mutant of a clinical isolate of Pseudomonas aeruginosa increased expression of the mexEF-oprN multidrug efflux genes and decreased production of outer membrane protein OprD, concomitant with enhanced resistance to chloramphenicol, quinolones, and imipenem, which was reminiscent of previously described nfxC mutants. PA2491 encodes a probable oxidoreductase previously shown to be positively regulated by the MexT positive regulator of mexEF-oprN expression (T. Köhler, S. F. Epp, L. K. Curty, and J. C. Pechére, J. Bacteriol. 181: 6300-6305, 1999). Spontaneous multidrug-resistant mutants of the P. aeruginosa clinical isolate hyperexpressing mexEF-oprN and showing reduced production of OprD were readily selected in vitro, and all of them were shown to carry mutations in PA2491, highlighting the probable significance of such mutations as determinants of MexEF-OprN-mediated multidrug resistance in vivo.
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Citations
Cited by
The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria
Li, X.-Z., Plésiat, P., & Nikaido, H. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00117-14 · Cited by 1,614
Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria
Piddock, L. J. V. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.19.2.382-402.2006 · Cited by 1,231
Efflux-mediated antimicrobial resistance
Poole, K. (2005) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dki171 · Cited by 1,082
Self-citationQuale, J., Bratu, S., Gupta, J., & Landman, D. (2006) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.50.5.1633-1641.2006 · Cited by 409
Metadata
- Authors
- Sobel, M. L., Neshat, S., & Poole, K.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 2005-02-15
- Volume
- 187
- Issue
- 4
- Pages
- 1246-1253
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W2151077811
- Cited by
- 176
- References
- 0
- FWCI
- 3.13
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Mutations in PA2491 ( mexS ) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa. https://app.cochat.ai/papers/10.1128/jb.187.4.1246-1253.2005
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- Sobel, M. L., Neshat, S., & Poole, K. (2005). Mutations in PA2491 ( mexS ) Promote MexT-Dependent mexEF-oprN Expression and Multidrug Resistance in a Clinical Strain of Pseudomonas aeruginosa. Journal of Bacteriology. https://doi.org/10.1128/jb.187.4.1246-1253.2005
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