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Mechanism of Action of Phenethyl Alcohol: Breakdown of the Cellular Permeability Barrier
Open accessAbstract
Phenethyl alcohol (PEA) caused Escherichia coli to take up greatly increased amounts of acriflavine, a compound to which healthy growing cells are impermeable. PEA also caused an increased rate of efflux (leakage) of cellular potassium under conditions which do not greatly alter the influx of potassium via the energy-dependent potassium pump. We therefore propose that the primary effect of PEA is a limited breakdown of the cell membrane. The inhibition of deoxyribonucleic acid synthesis and other cellular functions would then be secondary consequences of the alteration in the membrane structure.
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Citations
Cited by
Mechanisms of membrane toxicity of hydrocarbons
Sikkema, J., de Bont, J. A., & Poolman, B. (1995) · Microbiological Reviews · doi:10.1128/mr.59.2.201-222.1995 · Cited by 2,685
“Parallel experiments with toluene, conducted by these researchers, showed that the two compounds act via a similar mechanism (147, 279).”
BackgroundCarson, C. F., Mee, B. J., & Riley, T. V. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.46.6.1914-1920.2002 · Cited by 975
Effects of Alcohols on Micro-Organisms
Ingram, L. O., & Buttke, T. M. (1985) · Advances in Microbial Physiology · doi:10.1016/s0065-2911(08)60294-5 · Cited by 554
Gilbert, P., & McBain, A. J. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.2.189-208.2003 · Cited by 334
Mechanisms of action of antibacterial biocides
Denyer, S. P. (1995) · International Biodeterioration & Biodegradation · doi:10.1016/0964-8305(96)00015-7 · Cited by 324
Metadata
- Authors
- Silver, S., & Wendt, L.
- Venue
- Journal of Bacteriology
- Publisher
- American Society for Microbiology
- Published
- 1967-02
- Volume
- 93
- Issue
- 2
- Pages
- 560-566
- ISSN
- 0021-9193 (ISSN-L)
- 1098-5530
- OpenAlex
- W1484173541
- Cited by
- 187
- References
- 0
- FWCI
- 18.37
- Type
- journal article
- Language
- en
- Open access
- green
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- Silver, S., & Wendt, L. (1967). Mechanism of Action of Phenethyl Alcohol: Breakdown of the Cellular Permeability Barrier. Journal of Bacteriology. https://doi.org/10.1128/jb.93.2.560-566.1967
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