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Progress in Antifungal Susceptibility Testing of Candida spp. by Use of Clinical and Laboratory Standards Institute Broth Microdilution Methods, 2010 to 2012
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Antifungal susceptibility testing of Candida has been standardized and refined and now may play a useful role in managing Candida infections. Important new developments include validation of 24-h reading times for all antifungal agents and the establishment of species-specific epidemiological cutoff values (ECVs) for the systemically active antifungal agents and both common and uncommon species of Candida . The clinical breakpoints (CBPs) for fluconazole, voriconazole, and the echinocandins have been revised to provide species-specific interpretive criteria for the six most common species. The revised CBPs not only are predictive of clinical outcome but also provide a more sensitive means of identifying those strains with acquired or mutational resistance mechanisms. This brief review serves as an update on the new developments in the antifungal susceptibility testing of Candida spp. using Clinical and Laboratory Standards Institute (CLSI) broth microdilution (BMD) methods.
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Metadata
- Authors
- Pfaller, M. A., & Diekema, D. J.
- Affiliations
- University of Iowa (US)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2012-09
- Volume
- 50
- Issue
- 9
- Pages
- 2846-2856
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC3421803
- OpenAlex
- W2120299440
- Cited by
- 484
- References
- 105
- Citations by year
- 2026: 15 · 2025: 20 · 2024: 24 · 2023: 29 · 2022: 26 · 2021: 41 · 2020: 41 · 2019: 31 · 2018: 43 · 2017: 46 · 2016: 45 · 2015: 41 · 2014: 47 · 2013: 31 · 2012: 4
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Pfizer
- Eisai
- Astellas Pharma
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Microbiology (medical) › Bacterial Identification and Susceptibility Testing
- Life Sciences › Immunology and Microbiology › Microbiology › Yeasts and Rust Fungi Studies
- Keywords
- Candida, antifungal susceptibility testing, broth microdilution, epidemiological cut-off values, clinical breakpoints, fluconazole, voriconazole, echinocandins, antifungal resistance, Candida species, CLSI guidelines
- MeSH terms
- Antifungal Agents, Candida, Candidiasis, Humans, Microbial Sensitivity Tests
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