Cited by 51Antifungal resistance and susceptibilityBacterial Identification and Susceptibility TestingCOVID-19 Clinical Research Studies

Metagenomic Next-Generation Sequencing of Plasma for Diagnosis of COVID-19-Associated Pulmonary Aspergillosis

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Hoenigl, Martin, Egger, Matthias, Price, Jessica, Krause, Robert, Prattes, Juergen, White, P. Lewis·2023·Journal of Clinical Microbiology

Abstract

Timely diagnosis remains an unmet need in non-neutropenic patients at risk for aspergillosis, including those with COVID-19-associated pulmonary aspergillosis (CAPA), which in its early stages is characterized by tissue-invasive growth of the lungs with limited angioinvasion. Currently available mycological tests show limited sensitivity when testing blood specimens.

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Crossref · 10.1128/jcm.01859-22

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  • There is limited data for the diagnosis of invasive candidiasis by metagenomic next-generation sequencing, although early reports show potential.

    “There is limited data thus far for the diagnosis of invasive candidiasis by this methodology, although early reports show potential.24”

    From Epidemiology of Invasive Candidiasis (2024) · cites this paper as [24]

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Authors
Hoenigl, M., Egger, M., Price, J., Krause, R., Prattes, J., & White, P. L.
Affiliations
  • Medical University of Graz (AT)
  • University Hospital of Wales (GB)
  • University of Cologne (DE)
Corresponding author
  • Hoenigl, Martin
  • Prattes, Juergen
Venue
Journal of Clinical Microbiology
Published
2023-03-23
Volume
61
Issue
3
Pages
e0185922-e0185922
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
OpenAlex
W4321446994
Cited by
51
References
32
Citations by year
2026: 6 · 2025: 12 · 2024: 18 · 2023: 15
FWCI
10.56
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
Funders
Gilead Sciences (IIR)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
COVID-19-associated pulmonary aspergillosis, metagenomic next-generation sequencing, plasma cell-free DNA, Karius test, Aspergillus fumigatus, Rhizopus microsporus, mold detection, sensitivity and specificity, non-neutropenic patients, intensive care unit patients
MeSH terms
Cell-Free Nucleic Acids, COVID-19, Aspergillosis, Female, Humans, Male, Middle Aged

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