Isolation and identification of ATP-secreting bacteria from mice and humans
Open accessAbstract
In a recent report, ATP, which was possibly secreted by some intestinal bacteria, was shown to cause colitis in mice via Th17 cell differentiation. However, the ATP-secreting bacteria have not been isolated and identified. In the present study, we report that Enterococcus gallinarum, which is a vancomycin-resistant Gram-positive coccus isolated from mice and humans, secretes ATP.
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Some but not all intestinal bacteria actively secrete ATP, and germ-free mice have lower gut ATP concentrations than controls.
“some, but not all, intestinal bacteria actively secrete ATP, and germ-free mice have lower ATP concentrations in their gut than controls (Atarashi et al., 2008; Hironaka et al., 2013; Iwase et al., 2010).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Iwase et al., 2010
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Cites
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“For instance, some but not all intestinal bacteria actively secrete ATP, and germ-free mice have lower ATP concentrations in their gut than controls (Atarashi et al., 2008; Hironaka et al., 2013; Iwase et al., 2010).”
BackgroundGlucose triggers ATP secretion from bacteria in a growth-phase-dependent manner
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- Authors
- Iwase, T., Shinji, H., Tajima, A., Sato, F., Tamura, T., Iwamoto, T., Yoneda, M., & Mizunoe, Y.
- Affiliations
- Jikei University School of Medicine (JP)
- The Jikei University Hospital (JP)
- The University of Tokyo (JP)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2010-05
- Volume
- 48
- Issue
- 5
- Pages
- 1949-1951
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC2863903
- OpenAlex
- W20305009
- Cited by
- 61
- References
- 13
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 10 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 8 · 2018: 4 · 2017: 2 · 2016: 1 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Monograph Archive
- Funders
- Jikei University School of Medicine
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Adenosine and Purinergic Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Escherichia coli research studies
- Keywords
- ATP release, Enterococcus gallinarum, vancomycin resistance, colitis, Th17 cell differentiation, intestinal bacteria, Gram-positive cocci, bacterial isolation, mice, human
- MeSH terms
- Adenosine Triphosphate, Animals, Humans, Mice, Inbred BALB C, Enterococcus, Gastrointestinal Tract, Mice
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