The DOI matches its Crossref record.
Merthiolate treatment of pathogenic fungi
Open accessAbstract
The action of Merthiolate on the pathogenic yeasts Blastomyces, dermatitidis, Histoplasma capsulatum, and Sporothrix schenckii was compared to the effect of treatment with formaldehyde. Concentrations of 1:10,000 and 1:5,000 Merthiolate for three exposure times (24, 48, and 72 h) at 4 and 25 degrees C were tested on three media (brain heart infusion with and without blood, and modified Sabouraud agar). The effect of Merthiolate on these three yeasts was primarily fungistatic, with maximum effect using 1:5,000 Merthiolate at 25 degrees C for at least 48 h. Mycelial suspensions of B. dermatitidis, H. capsulatum, S. shenckii, and the yeast phase of Cryptococcus neoformans were susceptible to the 1:5,000 Merthiolate concentration after 24 h of treatment. The antifungal effect of Methiolate varies with species and growth phase of the fungus. Concentration, time of exposure, and temperature of incubation are important variables.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“This method of killing was used to minimize changes in the cell wall [52].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [52]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells
Phan, Q. T., Myers, C. L., Fu, Y., Sheppard, D. C., Yeaman, M. R., Welch, W. H., Ibrahim, A. S., Edwards, J. E., & Filler, S. G. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050064 · Cited by 641
“This method of killing was used to minimize changes in the cell wall [52].”
MethodPark, H., Myers, C. L., Sheppard, D. C., Phan, Q. T., Sanchez, A. A., E. Edwards, J., & Filler, S. G. (2004) · Cellular Microbiology · doi:10.1111/j.1462-5822.2004.00476.x · Cited by 207
“The metabolic poison, thimerosal, was used to avoid denaturation of candidal surface proteins and maintain cellular integrity (Deighton et al., 1979).”
MethodBertuzzi, M., Schrettl, M., Alcazar-Fuoli, L., Cairns, T. C., Muñoz, A., Walker, L. A., Herbst, S., Safari, M., Cheverton, A. M., Chen, D., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004413 · Cited by 158
“02% thimerosal (Sigma) overnight at 4uC [71], a treatment which preserves cellular integrity.”
BackgroundLopes-Bezerra, L. M., & Filler, S. G. (2003) · Blood · doi:10.1182/blood-2003-06-2186 · Cited by 120
Sulphate metabolism of selenate-resistant Schizosaccharomyces pombe mutants.
Bánszky, L., Simonics, T., & Maráz, A. (2003) · Journal of General and Applied Microbiology · doi:10.2323/jgam.49.271 · Cited by 21
Metadata
- Authors
- Deighton, F. J., Hall, N. K., & Larsh, H. W.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1979-08
- Volume
- 10
- Issue
- 2
- Pages
- 144-146
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC273118
- OpenAlex
- W1775936931
- Cited by
- 11
- References
- 0
- Citations by year
- 2014: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- thimerosal, antifungal agents, pathogenic yeasts, Blastomyces dermatitidis, Histoplasma capsulatum, Sporothrix schenckii, Cryptococcus neoformans, formaldehyde, fungistatic activity, temperature dependence, incubation time, fungal growth phase
- MeSH terms
- Blastomyces, Cryptococcus, Cryptococcus neoformans, Ethylmercury Compounds, Histoplasma, Sporothrix, Temperature, Thimerosal
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Merthiolate treatment of pathogenic fungi. https://app.cochat.ai/papers/10.1128/jcm.10.2.144-146.1979
- The paper
- Deighton, F. J., Hall, N. K., & Larsh, H. W. (1979). Merthiolate treatment of pathogenic fungi. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.10.2.144-146.1979
