The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Detection of Rickettsia rickettsii DNA in clinical specimens by using polymerase chain reaction technology
Open accessAbstract
A polymerase chain reaction (PCR) procedure for detecting rickettsial DNA was developed and shown to be specific for Rickettsia rickettsii and R. conorii, the etiologic agents of Rocky Mountain spotted fever (RMSF) and Boutonneuse fever, respectively. Blood clots were obtained from nine confirmed RMSF patients and six controls and analyzed for the presence of rickettsial DNA by the PCR method. A defined region of the rickettsial genome was successfully amplified from seven of the nine clinical specimens tested; all six control specimens gave negative results. These findings indicate that R. rickettsii can be detected early after the onset of RMSF, possibly facilitating the decision regarding appropriate antibiotic therapy for some patients. Further refinement of PCR technology could make this procedure a mainstay in the clinical laboratory.
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Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Cited by
Tick-Borne Rickettsioses around the World: Emerging Diseases Challenging Old Concepts
Parola, P., Paddock, C. D., & Raoult, D. (2005) · Clinical Microbiology Reviews · doi:10.1128/cmr.18.4.719-756.2005 · Cited by 1,158
Ehrlichia chaffeensis, a new species associated with human ehrlichiosis
Anderson, B. E., Dawson, J. E., Jones, D. C., & Wilson, K. H. (1991) · Journal of Clinical Microbiology · doi:10.1128/jcm.29.12.2838-2842.1991 · Cited by 521
Self-citationLa Scola, B., & Raoult, D. (1997) · Journal of Clinical Microbiology · doi:10.1128/jcm.35.11.2715-2727.1997 · Cited by 489
Rocky Mountain Spotted Fever from an Unexpected Tick Vector in Arizona
Demma, L. J., Traeger, M. S., Nicholson, W. L., Paddock, C. D., Blau, D. M., Eremeeva, M. E., Dasch, G. A., Levin, M. L., Singleton, J., Zaki, S. R., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa050043 · Cited by 462
STENOS, J., GRAVES, S. R., & UNSWORTH, N. B. (2005) · The American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2005.73.1083 · Cited by 299
Metadata
- Authors
- Tzianabos, T., Anderson, B. E., & McDade, J. E.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1989-12
- Volume
- 27
- Issue
- 12
- Pages
- 2866-2868
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W1645904653
- Cited by
- 186
- References
- 1
- FWCI
- 8.46
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Detection of Rickettsia rickettsii DNA in clinical specimens by using polymerase chain reaction technology. https://app.cochat.ai/papers/10.1128/jcm.27.12.2866-2868.1989
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- Tzianabos, T., Anderson, B. E., & McDade, J. E. (1989). Detection of Rickettsia rickettsii DNA in clinical specimens by using polymerase chain reaction technology. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.27.12.2866-2868.1989
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
