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Cited by 94Antifungal resistance and susceptibilityFungal and yeast genetics researchImmunodeficiency and Autoimmune Disorders

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Detection of Aspergillus antigens associated with invasive infection

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Haynes, K A, Latge, J P, Rogers, T R·1990·Journal of Clinical Microbiology
DOI 10.1128/jcm.28.9.2040-2044.1990PMC PMC268100
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Abstract

Serial urine samples were collected from 33 neutropenic patients, 10 of whom developed invasive aspergillosis (IA) while undergoing bone marrow transplantation or remission induction therapy for leukemia. Concentrated urine samples from the infected patients were subjected to polyacrylamide gel electrophoresis, blotted, and then incubated with antiserum raised to a cell wall extract of Aspergillus fumigatus (anti-CW) or an immunoglobulin G monoclonal antibody to A. fumigatus galactomannan (EBA1). When IA patient urine blots were probed with anti-CW, major bands at 11 and 18 kilodaltons (kDa); intermediate bands at 13, 14, and 29 kDa; and minor bands at 38 and 44 kDa were seen. In contrast, EBA1 showed diffuse staining at molecular masses larger than 45 kDa and a single weak band at 21 kDa. Urine samples from the 23 patients with no evidence of IA were unreactive with both anti-CW and EBA1. These antigen bands are likely to represent immunodominant antigens which are excreted during IA and should play a valuable role in the development of rapid diagnostic tests for aspergillosis.

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Crossref · 10.1128/jcm.28.9.2040-2044.1990

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  1. Rinaldi M. G. Invasive aspergillosis. Rev Infect Dis. 1983 Nov-Dec;5(6):1061–1077. doi: 10.1093/clinids/5.6.1061. [DOI] [PubMed] [Google Scholar] · DOI

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Metadata

Authors
Haynes, K. A., Latge, J. P., & Rogers, T. R.
Affiliations
  • Charing Cross Hospital (GB)
  • Department of Medical Microbiology, Charing Cross and Westminister Medical School, London United Kingdom.
ORCID
Rogers, T R
Venue
Journal of Clinical Microbiology
Publisher
American Society for Microbiology
Published
1990-09
Volume
28
Issue
9
Pages
2040-2044
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
DOI
10.1128/jcm.28.9.2040-2044.1990
PMC
PMC268100
OpenAlex
W1568021747
Cited by
94
References
32
Citations by year
2026: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2016: 2 · 2015: 1 · 2013: 2 · 2012: 2
FWCI
7.55
Type
journal article
Language
en
Open access
Licence
journals.asm.org/non-commercial-tdm-license (tdm)
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
  • Life Sciences › Immunology and Microbiology › Immunology › Immunodeficiency and Autoimmune Disorders
Keywords
invasive aspergillosis, Aspergillus fumigatus, urine antigen detection, immunodominant antigens, cell wall antigens, galactomannan, neutropenic patients, bone marrow transplantation, rapid diagnostic tests
MeSH terms
Antibodies, Fungal, Antibodies, Monoclonal, Antigens, Fungal, Aspergillosis, Aspergillus fumigatus, Cell Wall, Humans, Molecular Weight, Immunoblotting

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