Cited by 192Antifungal resistance and susceptibilityInfection Control in HealthcareFungal and yeast genetics research

Molecular Typing of Environmental and Patient Isolates of Aspergillus fumigatus from Various Hospital Settings

Open access
Chazalet, Valérie, Debeaupuis, Jean-Paul, Sarfati, Jacqueline, Lortholary, Jacques, Ribaud, Patricia, Shah, Pramod, Cornet, Muriel, Thien, Hoang Vu +3 more·1998·Journal of Clinical Microbiology

Abstract

Fingerprinting of more than 700 clinical and environmental isolates of Aspergillus fumigatus from four differential hospital settings was undertaken with a dispersed repeated DNA sequence. The analysis of the environmental isolates showed that the airborne A. fumigatus population is extremely diverse, with 85% of the strains being represented as a single genotype isolated once. The remaining 15% of the strains were isolated several times and were able to persist for several months in the same hospital environment. No strains were found to be associated with a specific location inside the hospital, and identical strains were isolated from different buildings of the hospital and outdoors. Isolation of the same strain both from patients and from the environment of the same hospital is highly suggestive of a nosocomial infection. The characteristics of the environmental fungal population explains the two main results obtained from the typing of the clinical isolates: (i) the absence of a common strain responsible for an invasive aspergillosis outbreak results from the extreme diversity of the environmental population of A. fumigatus in contact with the patients, and (ii) patients hospitalized in different wards of the same hospital can be infected with the same strain since every patient might inhale the same spore population.

Integrity signals

Registry

Crossref · 10.1128/jcm.36.6.1494-1500.1998

Cites

45 of 45 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Population genetic studies provide evidence for recombination in A. fumigatus.

    “First, evidence for recombination came from population genetic studies (4, 5).”

    From Aspergillus fumigatus and Aspergillosis in 2019 (2019) · cites this paper as [4]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Chazalet, V., Debeaupuis, J.-P., Sarfati, J., Lortholary, J., Ribaud, P., Shah, P., Cornet, M., Thien, H. V., Gluckman, E., Brücker, G., & Latgé, J.-P.
Affiliations
  • Institut Pasteur (FR)
  • Assistance Publique – Hôpitaux de Paris (FR)
  • Hôpital Saint-Louis (FR)
  • University Hospital Frankfurt (DE)
  • Hôtel-Dieu de Paris (FR)
  • <!--label omitted: 6-->Laboratoire de Microbiologie, Hôpital Trousseau, 75012 Paris,6 France, and
  • <!--label omitted: 3-->Unité de Greffe de Moelle Osseuse, Hôpital St Louis, 75010 Paris,3
  • <!--label omitted: 2-->Assistance Publique Hôpitaux de Paris, SEHP, 75001 Paris,2
  • <!--label omitted: 1-->Laboratoire des Aspergillus, Institut Pasteur, 75015 Paris,1
Venue
Journal of Clinical Microbiology
Published
1998-06
Volume
36
Issue
6
Pages
1494-1500
ISSN
  • 0095-1137 (ISSN-L)
  • 1098-660X
OpenAlex
W2146377737
Cited by
192
References
45
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 5 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 2 · 2015: 8 · 2014: 13 · 2013: 4 · 2012: 12
FWCI
6.52
Type
journal article
Language
en
Open access
Locations
  • Journal of Clinical Microbiology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
  • Health Sciences › Medicine › Infectious Diseases › Infection Control in Healthcare
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords
Aspergillus fumigatus, molecular typing, environmental isolates, nosocomial infections, invasive aspergillosis, outbreak, hospital wards, strain persistence
MeSH terms
Air Microbiology, Aspergillosis, Aspergillus fumigatus, DNA, Fungal, Genotype, Hospitals, Humans, DNA Fingerprinting, Mycological Typing Techniques, Molecular Epidemiology

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review