Hospital Specificity, Region Specificity, and Fluconazole Resistance of Candida albicans Bloodstream Isolates

Pfaller, M. A.; Lockhart, S. R.; Pujol, C.; Swails-Wenger, J. A.; Messer, S. A.; Edmond, M. B.; Jones, R. N.; Wenzel, R. P.; Soll, D. R.

doi:10.1128/jcm.36.6.1518-1529.1998

Cited by 91Antifungal resistance and susceptibilityYeasts and Rust Fungi StudiesFungal and yeast genetics research

Hospital Specificity, Region Specificity, and Fluconazole Resistance of Candida albicans Bloodstream Isolates

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Pfaller, M. A., Lockhart, S. R., Pujol, C., Swails-Wenger, J. A., Messer, S. A., Edmond, M. B., Jones, R. N., Wenzel, R. P. +1 more·1998·Journal of Clinical Microbiology

DOI 10.1128/jcm.36.6.1518-1529.1998PMC PMC104870

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Abstract

In a survey of bloodstream infection (BSI) isolates across the continental United States, 162 Candida albicans isolates were fingerprinted with the species-specific probe Ca3 and the patterns were analyzed for relatedness with a computer-assisted system. The results demonstrate that particular BSI strains are more highly concentrated in particular geographic locales and that established BSI strains are endemic in some, but not all, hospitals in the study and undergo microevolution in hospital settings. The results, however, indicate no close genetic relationship among fluconazole-resistant BSI isolates in the collection, either from the same geographic locale or the same hospital. This study represents the first of three fingerprinting studies designed to analyze the origin, genetic relatedness, and drug resistance of Candida isolates responsible for BSI.

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Epidemiological data suggest that the intensity of fluconazole use is driving the appearance of resistant isolates.
“Epidemiological data suggest that the intensity of fluconazole use is driving the appearance of resistant isolates (Pfaller et al., 1998).”
From The evolution of drug resistance in clinical isolates of Candida albicans. (2015) · cites this paper as Pfaller et al., 1998
The greatest concern for fluconazole resistance relates to C. glabrata, for which rates of resistance as high as 15% have been reported.
“The greatest concern for fluconazole resistance relates to C. glabrata, for which rates of resistance as high as 15% have been reported [40].”
From Guidelines for Treatment of Candidiasis (2004) · cites this paper as [40]

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[Fluconazole resistance in Candida albicans assayed by PCR fingerprinting with M13 prime].
Wang, Y.-B., Wang, H., Guo, H.-Y., Zhao, Y.-Z., & Luo, S.-Q. (2003) · PubMed

Authors: Pfaller, M. A., Lockhart, S. R., Pujol, C., Swails-Wenger, J. A., Messer, S. A., Edmond, M. B., Jones, R. N., Wenzel, R. P., & Soll, D. R.
Affiliations: Departments of Pathology1 and
University of Iowa (US)
Virginia Commonwealth University (US)
ORCID: Pfaller, M. A.
Lockhart, S. R.
Messer, S. A.
Edmond, M. B.
Jones, R. N.
Wenzel, R. P.
Soll, D. R.
Venue: Journal of Clinical Microbiology
Publisher: American Society for Microbiology
Published: 1998-06
Volume: 36
Issue: 6
Pages: 1518-1529
ISSN: 0095-1137 (ISSN-L)
1098-660X
DOI: 10.1128/jcm.36.6.1518-1529.1998
PMC: PMC104870
OpenAlex: W2113338279
Cited by: 91
References: 38
Citations by year: 2024: 1 · 2023: 1 · 2021: 1 · 2019: 1 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
FWCI: 7.56
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Clinical Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (Z01AG000214, T32AG000214)
National Institute of Allergy and Infectious Diseases (AI-2392)
National Institute of Dental and Craniofacial Research (DE1058)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Keywords: Candida albicans, bloodstream infection, fluconazole resistance, microevolution, genetic relatedness, strain fingerprinting, species-specific probes, antifungal resistance
MeSH terms: Antifungal Agents, Candida albicans, Candidiasis, Cross Infection, DNA, Fungal, Drug Resistance, Microbial, Hospitals, Humans, Microbial Sensitivity Tests, Phylogeny, Species Specificity, United States, Fluconazole, DNA Fingerprinting, Fungemia

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Hospital Specificity, Region Specificity, and Fluconazole Resistance of Candida albicans Bloodstream Isolates

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