Chronic Urinary Tract Infection Due to Candida utilis
Open accessAbstract
An elderly male was seen at an outpatient urology clinic over a period of 3 years with repeat urine specimens containing 10 4 to 10 5 CFU of a “ Candida species, not C. albicans .” The urine specimens were described as infected due to the presence of pyuria, but no antifungal therapy was administered. On two occasions, the patient presented to the emergency room and urine specimens were sent to the clinical microbiology laboratory. On both occasions, a yeast was isolated at concentrations of >10 5 CFU/ml. The organism was identified as the anamorphic yeast Candida utilis (teleomorph: Pichia jadinii ) by conventional methods. Molecular methods, including karyotyping and restriction enzyme analysis, confirmed that the isolates were identical and were C. utilis . The patient developed benign prostatic hypertrophy and chronic obstructive pulmonary disease during the 3-year course. This report is the first demonstration of the isolation of the industrially important yeast C. utilis from a urinary tract infection. In the present case, the organism was associated with chronic, symptomatic disease. The significance of this unusual, low-virulence isolate from a case of urinary tract infection is discussed.
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C. utilis, a yeast used in biotechnology, has been reported as an opportunistic pathogen in fungemia.
“Among those unconventional opportunistic pathogen Candida species, C. utilis, a yeast commonly used with biotechnological purposes such as single-cell protein production, has been reported in opportunistic fungemia.1,6,17”
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- Authors
- Hazen, K. C., Theisz, G. W., & Howell, S. A.
- Affiliations
- University of Virginia Health System (US)
- St Thomas' Hospital (GB)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1999-03
- Volume
- 37
- Issue
- 3
- Pages
- 824-827
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC84571
- OpenAlex
- W2128372104
- Cited by
- 35
- References
- 28
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 3 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Health Sciences › Medicine › Epidemiology › Urinary Tract Infections Management
- Keywords
- Candida utilis, urinary tract infection, chronic infection, anamorphic yeast, pyuria, elderly man, karyology, restriction enzyme analysis, molecular identification
- MeSH terms
- Aged, Antifungal Agents, Candida, Candidiasis, Chronic Disease, Humans, Instillation, Drug, Lung Diseases, Obstructive, Male, Neomycin, Prostatic Hyperplasia, Recurrence, Urinary Tract Infections
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