Catheter-associated Candida utilis fungemia in a patient with acquired immunodeficiency syndrome: species verification with a molecular probe
Open accessAbstract
Candida utilis was cultured from the blood of a patient with acquired immunodeficiency syndrome. The candidemia was apparently associated with catheter implantation. The isolate was identified initially by standard methods and verified by molecular probing. The pattern of actin-specific restriction fragments obtained from the DNA of the isolate, probed with C. albicans actin sequences, corresponded to that of C. utilis. This organism adds to the growing list of Candida species associated with human disease. Molecular probing offers a definitive identification when an unexpected etiological agent is found.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
Odds, F. C. (1979) · Medical Entomology and Zoology · Cited by 1,297 · see citing works
Opportunistic Infections and Immune Deficiency in Homosexual Men
Mildvan, D., MATHUR, U., ENLOW, R. W., ROMAIN, P. L., WINCHESTER, R. J., COLP, C., SINGMAN, H., ADELSBERG, B. R., & SPIGLAND, I. (1982) · Annals of Internal Medicine · doi:10.7326/0003-4819-96-6-700 · Cited by 377 · see citing works
Haley, L. D. (1961) · American Journal of Clinical Pathology · doi:10.1093/ajcp/36.3.227 · Cited by 216 · see citing works
DNA content, kinetic complexity, and the ploidy question in Candida albicans.
Riggsby, W. S., Torres-Bauzá, L. J., Wills, J. W., & Townes, T. M. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.7.853 · Cited by 152 · see citing works
Self-citationIncreased incidence of fungemia caused by Candida krusei
Merz, W. G., Karp, J. E., Schron, D., & Saral, R. (1986) · Journal of Clinical Microbiology · doi:10.1128/jcm.24.4.581-584.1986 · Cited by 139 · see citing works
Mycoses Caused by Candida lusitaniae
Hadfield, T. L., Smith, M. B. H., Winn, R. E., Rinaldi, M. G., & Guerra, C. (1987) · Clinical Infectious Diseases · doi:10.1093/clinids/9.5.1006 · Cited by 139 · see citing works
Risk of familial breast cancer
Anderson, D. E., & Badzioch, M. D. (1985) · Cancer · doi:10.1002/1097-0142(19850715)56:2 · Cited by 113 · see citing works
Evaluation of the modified API 20C system for identification of clinically important yeasts
Buesching, W. J., Kurek, K., & Roberts, G. D. (1979) · Journal of Clinical Microbiology · doi:10.1128/jcm.9.5.565-569.1979 · Cited by 112 · see citing works
Molecular probe for identification of medically important Candida species and Torulopsis glabrata
Mason, M., Lasker, B. A., & Riggsby, W. S. (1987) · Journal of Clinical Microbiology · doi:10.1128/jcm.25.3.563-566.1987 · Cited by 82 · see citing works
Self-citationKetoconazole-resistant Candida esophagitis in patients with acquired immunodeficiency syndrome
Tavitian, A., Raufman, J., Rosenthal, L. E., Weber, J., Webber, C. A., & Dincsoy, H. P. (1986) · Gastroenterology · doi:10.1016/0016-5085(86)90946-7 · Cited by 81 · see citing works
Evaluation of industrial yeasts for pathogenicity
Holzschu, D. L., Chandler, F. W., Ajello, L., & Ahearn, D. G. (1979) · Medical Mycology · doi:10.1080/00362177985380091 · Cited by 59 · see citing works
Christenson, J. C., Guruswamy, A. P., Mukwaya, G., & RETTING, P. J. (1987) · The Pediatric Infectious Disease Journal · doi:10.1097/00006454-198708000-00013 · Cited by 47 · see citing works
Intravenous catheter-associated fungemia due to Candida rugosa
Reinhardt, J. F., Ruane, P. J., Walker, L. J., & George, W. L. (1985) · Journal of Clinical Microbiology · doi:10.1128/jcm.22.6.1056-1057.1985 · Cited by 41 · see citing works
Torulopsis candida, a new opportunistic pathogen
St‐Germain, G., & Laverdière, M. (1986) · Journal of Clinical Microbiology · doi:10.1128/jcm.24.5.884-885.1986 · Cited by 38 · see citing works
DNA Content, Kinetic Complexity, and the Ploidy Question in Candida albicans
Riggsby, W. S., Torres-Bauzá, L. J., Wills, J. W., et al. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.7.853-862.1982 · Cited by 35 · see citing works
Self-citationCandida lusitaniae: sepsis and meningitis in a neonate.
Sanchez, P. J., & Cooper, B. H. (1987) · PubMed · Cited by 34 · see citing works
Tchekmedyian, N. S., Newman, K. A., Moody, M. R., Costerton, J. W., Aisner, J., Schimpff, S. C., & Reed, W. P. (1986) · The American Journal of the Medical Sciences · doi:10.1097/00000441-198606000-00009 · Cited by 30 · see citing works
Taxonomic and nomenclatural evaluation of the genera Candida and Torulopsis
McGinnis, M. R., Ajello, L., Beneke, E. S., Drouhet, E., Goodman, N. L., Halde, C., Haley, L. D., Kane, J. R., Land, G. A., & Padhye, A. A. (1984) · Journal of Clinical Microbiology · doi:10.1128/jcm.20.4.813-814.1984 · Cited by 23 · see citing works
Growth of Candida utilis on ethanol and isopropanol
Prior, B. A., Kilian, S. G., & Lategan, P. M. (1980) · Archives of Microbiology · doi:10.1007/bf00403209 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
New and emerging yeast pathogens
Hazen, K. C. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.4.462 · Cited by 613 · see citing works
The Ins and Outs of DNA Fingerprinting the Infectious Fungi
Soll, D. R. (2000) · Clinical Microbiology Reviews · doi:10.1128/cmr.13.2.332-370.2000 · Cited by 348 · see citing works
Scherer, S., & Magee, P. T. (1990) · Microbiological Reviews · doi:10.1128/mr.54.3.226-241.1990 · Cited by 225 · see citing works
Pathobiology of Infection in Prosthetic Devices
Dougherty, S. H. (1988) · Clinical Infectious Diseases · doi:10.1093/clinids/10.6.1102 · Cited by 193 · see citing works
Coleman, D. C., Sullivan, D. J., Harrington, B. J., Haynes, K., Henman, M. C., Shanley, D. B., Bennett, D. E., Moran, G. P., McCreary, C., & O'Neill, L. C. (1997) · Oral Diseases · doi:10.1111/j.1601-0825.1997.tb00384.x · Cited by 95 · see citing works
Sullivan, D. J., Henman, M. C., Moran, G. P., O'Neill, L. C., Bennett, D. E., Shanley, D. B., & Coleman, D. C. (1996) · Journal of Medical Microbiology · doi:10.1099/00222615-44-6-399 · Cited by 94 · see citing works
Kaplan, J. E., Masur, H., Holmes, K. K., Wilfert, C. M., SPERLING, R. S., Baker, S. A., Trapnell, C. B., Freedberg, K. A., Cotton, D. J., Powderly, W. G., et al. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/21.supplement_1.s12 · Cited by 87 · see citing works
Walsh, T. J., Gonzalez, C. E., Roilides, E., Mueller, B. U., Ali, N. A. S., Lewis, L. L., Whitcomb, T. O., Marshall, D. J., & Pizzo, P. A. (1995) · Clinical Infectious Diseases · doi:10.1093/clinids/20.4.900 · Cited by 84 · see citing works
Vázquez, J. A., Beckley, A., Donabedian, S. M., Sobel, J. D., & Zervos, M. (1993) · Journal of Clinical Microbiology · doi:10.1128/jcm.31.8.2021-2030.1993 · Cited by 74 · see citing works
“glabrata or the other Candida species (2, 13).”
BackgroundGonzalez, C. E., Venzon, D. J., Lee, S., Mueller, B. U., Pizzo, P. A., & Walsh, T. J. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/23.3.515 · Cited by 64 · see citing works
“Recently, fungemia (with a relatively high frequency of 7%) also has been described in the pediatric population of HIV-infected patients [17,23-25].”
BackgroundCabral, M. E., Figueroa, L. I. C., & Fariña, J. I. (2013) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2012.09.006 · Cited by 54 · see citing works
Chronic Urinary Tract Infection Due to <i>Candida utilis</i>
Hazen, K. C., Theisz, G. W., & Howell, S. A. (1999) · Journal of Clinical Microbiology · doi:10.1128/jcm.37.3.824-827.1999 · Cited by 35 · see citing works
“utilis has been reported as a rare agent of fungemia (2, 6).”
BackgroundSepticaemia in patients with AIDS
Shanson, D. C. (1990) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/0035-9203(90)90449-o · Cited by 33 · see citing works
Sensibilidad a antifúngicos de levaduras patógenas emergentes
García-Martos, P., Domínguez, I., Marín, P., García-Agudo, R., Aoufi, S., & Mira, J. (2001) · Enfermedades Infecciosas y Microbiología Clínica · doi:10.1016/s0213-005x(01)72630-4 · Cited by 33 · see citing works
Resolutive Candida utilis fungemia in a nonneutropenic patient
Bougnoux, M. E., Gueho, E., & Potocka, A. C. (1993) · Journal of Clinical Microbiology · doi:10.1128/jcm.31.6.1644-1645.1993 · Cited by 30 · see citing works
“utilis has been reported only once as an opportunistic pathogen, when it was isolated from the blood of a neutropenic AIDS patient with a catheter (1).”
BackgroundCandida utilis candidaemia in neonatal patients
Lukić-Grlić, A., Mlinarić-Missoni, E., Škarić, I., Važić-Babić, V., & Svetec, I. (2011) · Journal of Medical Microbiology · doi:10.1099/jmm.0.023408-0 · Cited by 25 · see citing works
“To the best of our knowledge, only two cases of C. utilis candidaemia have been reported in the literature to date (Alsina et al., 1988; Bougnoux et al., 1993).”
BackgroundInfluentialCatheter-related bloodstream infection by Lindnera fabianii in a neutropenic patient
Yun, J. W., Park, K., Ki, C., & Lee, N. Y. (2013) · Journal of Medical Microbiology · doi:10.1099/jmm.0.048306-0 · Cited by 23 · see citing works
“Only a few cases of invasive human infection including fungaemia, fungal keratitis and urinary tract infection have been reported in the literature (Alsina et al., 1988; Bougnoux et al., 1993; Hazen et al., 1999; Lukić-Grlić et al., 2011; Shih et al., 1999).”
BackgroundCandida utilis catheter-related bloodstream infection
Scoppettuolo, G., Donato, C., Carolis, E. D., Vella, A., Vaccaro, L., Greca, A. L., & Fantoni, M. (2014) · Medical Mycology Case Reports · doi:10.1016/j.mmcr.2014.10.003 · Cited by 22 · see citing works
Identification and characterization ofCandida utilismultidrug efflux transporterCuCdr1p
Watanasrisin, W., Iwatani, S., Oura, T., Tomita, Y., Ikushima, S., Chindamporn, A., Niimi, M., Niimi, K., Lamping, E., Cannon, R. D., et al. (2016) · FEMS Yeast Research · doi:10.1093/femsyr/fow042 · Cited by 20 · see citing works
Jindal, N., Arora, S. K., Dhuria, N., & Arora, D. (2015) · JMM Case Reports · doi:10.1099/jmmcr.0.000033 · Cited by 19 · see citing works
“It has rarely been described in humans and only a few cases of invasive human infections [fungaemia (Alsina et al., 1988; Bougnoux et al., 1993), fungal keratitis (Shih et al.”
BackgroundTreguier, P., David, M., Gargala, G., Camus, V., Stamatoullas, A., Ménard, A., Lenain, P., Contentin, N., Lemasle, É., Lanic, H., et al. (2018) · JMM Case Reports · doi:10.1099/jmmcr.0.005160 · Cited by 14 · see citing works
“The first was in 1988 in a 5-year-old male haemophiliac with AIDS and a central catheter [6].”
BackgroundMycoses in AIDS Patients: An Overview
Drouhet, E., & Dupont, B. (1990) · Springer eBooks · doi:10.1007/978-1-4613-0655-9_3 · Cited by 14 · see citing works
Genetic diversity of the yeast Candida utilis
Stoltenburg, R., Klinner, U., Ritzerfeld, P., Zimmermann, M., & Emeis, C. C. (1992) · Current Genetics · doi:10.1007/bf00326408 · Cited by 13 · see citing works
Candida utilis: a rare cause of septicemia in children
Sreelekshmi, T. S., Ninan, M. M., Lionel, A. P., Chacko, A., Sahni, R. D., & Michael, J. S. (2021) · Access Microbiology · doi:10.1099/acmi.0.000281 · Cited by 10 · see citing works
“[12] Catheterassociated Candida utilis fungemia in a patient with acquired immunodeficiency syndrome: species verification with a molecular probe Tennessee 1; 5 year old”
BackgroundVoß, A., Pfaller, M. A., Hollis, R. J., Melchers, W. J. G., & Meis, J. F. G. M. (1998) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.1998.tb00360.x · Cited by 10 · see citing works
Nnalue, N. A., Weintraub, A., & Lindberg, A. A. (1991) · Infection and Immunity · doi:10.1128/iai.59.1.229-233.1991 · Cited by 9 · see citing works
“More Candida species are being recognized as agents of disease in immunocompromised persons, especially in cancer and AIDS patients (1, 2, 34).”
BackgroundGaisne, R., Jeddi, F., Morio, F., Clerc, Q. L., Hourmant, M., Blancho, G., Giral, M., Cantarovich, D., Dantal, J., & Ville, S. (2018) · Mycoses · doi:10.1111/myc.12766 · Cited by 8 · see citing works
Marsaux, B., Moens, F., Marzorati, M., & de Wiele, T. V. (2023) · Journal of Fungi · doi:10.3390/jof9090877 · Cited by 5 · see citing works
Microbial levels on the food preparation areas of a typical district hospital in South Africa
Setlhare, G., Malebo, N. J., Shale, K., & Lues, J. F. R. (2013) · African Journal of Microbiology Research · doi:10.5897/ajmr2013.5796 · Cited by 4 · see citing works
Evaluation of Commercial Kits and Systems for the Rapid Identification and Biotyping of Yeasts
Land, G. A., McGinnis, M. R., & Salkin, I. F. (1991) · Springer eBooks · doi:10.1007/978-3-642-76603-9_43 · Cited by 4 · see citing works
Candidemia in Patients with Acquired Immunodeficiency Syndrome
Chu, F. E., Carrow, M., Blevins, A., & Armstrong, D. (1990) · Springer eBooks · doi:10.1007/978-1-4613-0655-9_6 · Cited by 4 · see citing works
The mycobiota of landfill leachates in the pretreatment process in a sequencing batch reactor
Szyłak-Szydłowski, M., & Korniłłowicz-Kowalska, T. (2012) · Open Life Sciences · doi:10.2478/s11535-012-0010-y · Cited by 3 · see citing works
An infant with a palatal fistula secondary to Candida infection
Sharma, S., & Chauhan, J. S. (2020) · Archives of Craniofacial Surgery · doi:10.7181/acfs.2020.00136 · Cited by 3 · see citing works
“utilis has long been known for its industrial applications, but it has rarely been described as an infectious agent in humans [5-7].”
Background(2011) · Elsevier eBooks · doi:10.1016/b978-0-444-52149-1.00187-7 · Cited by 3 · see citing works
Candidémie a candida utilis chez un patient de réanimation, résistant au traitement par fluconazole
Dekeyser, S., Desmettre, T., Scala, L., Dufossez, M.-C., Belletante, D., & Descamps, D. (2003) · Médecine et Maladies Infectieuses · doi:10.1016/s0399-077x(03)00062-3 · Cited by 2 · see citing works
Candida Utilis and Candida Lusitaniae Meningitis in an Infant with Extraventricular Drainage
Sarıgüzel, F. M., Koç, A. N., & Öztürk, M. (2017) · Van Medical Journal · doi:10.5505/vtd.2017.69783 · Cited by 2 · see citing works
“(2) reported catheter associated fungemia causing C.”
BackgroundInfluentialMicrobiology of Infection in Prosthetic Devices
Dougherty, S. H. (1990) · Springer eBooks · doi:10.1007/978-1-4471-3454-1_46 · Cited by 2 · see citing works
Characterisation of the malate transporter and malic enzyme from Candida utilis
Saayman, M. (2011) · SUNScholar (Stellenbosch University)
Emerging Candida spp. Infections
Georgiev, V. S. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-296-8_21
Péritonite à Candida utilis : une pathologie sous-estimée due à une levure « non pathogène »
Lefranc, M., Rougeron, A., Gabriel, F., & Accoceberry, I. (2017) · Journal de Mycologie Médicale · doi:10.1016/j.mycmed.2017.04.064
Canine pododermatitis caused by Pichia jadinii
Pieper, J. B., & Piccione, M. L. (2017) · Veterinary Record Case Reports · doi:10.1136/vetreccr-2017-000487
Paulovičová, E., & Hrubiško, M. (2021) · Immunobiology · doi:10.1016/j.imbio.2021.152154
- Authors
- Alsina, A., Mason, M., Uphoff, R. A., Riggsby, W. S., Becker, J. M., & Murphy, D.
- Affiliations
- University of Tennessee at Knoxville (US)
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 1988-04
- Volume
- 26
- Issue
- 4
- Pages
- 621-624
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- PMC
- PMC266390
- OpenAlex
- W2151953284
- Cited by
- 44
- References
- 18
- Citations by year
- 2023: 1 · 2021: 2 · 2020: 1 · 2018: 2 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 2 · 2012: 2
- FWCI
- 3.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Clinical Microbiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (AI-14387)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Plant Pathogens and Fungal Diseases
- Keywords
- Candida utilis, candidemia, catheter-related infection, AIDS, molecular identification, fungal identification, blood culture
- MeSH terms
- Acquired Immunodeficiency Syndrome, Candida, Candidiasis, Catheterization, Central Venous, Catheters, Indwelling, Child, Preschool, DNA, Fungal, Humans, Male, Parenteral Nutrition, Total, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
