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Antibiotic-Associated Diarrhea Accompanied by Large-Scale Alterations in the Composition of the Fecal Microbiota
Open accessAbstract
Alterations in the diversity of the gut microbiota are believed to underlie the development of antibiotic-associated diarrhea (AAD). A molecular phylogenetic analysis was performed to document temporal changes in the diversity of fecal bacteria of a patient who developed AAD. Antibiotic administration was associated with distinct changes in the diversity of the gut microbiota, including a marked decrease in the prevalence of butyrate-producing bacteria. Following the discontinuation of the antibiotic, resolution of diarrhea was accompanied by a reversal of these changes, providing the first direct evidence linking changes in the community structure of the gastrointestinal bacteria with the development of AAD.
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Citations
Cites
Mechanisms and Management of Antibiotic‐Associated Diarrhea
Hogenauer, C., Hammer, H. F., Krejs, G. J., & Reisinger, E. C. (1998) · Clinical Infectious Diseases · doi:10.1086/514958 · Cited by 348
McCracken, V. J., & Lorenz, R. G. (2001) · Cellular Microbiology · doi:10.1046/j.1462-5822.2001.00090.x · Cited by 314
Cited by
Diversity, stability and resilience of the human gut microbiota
Lozupone, C. A., Stombaugh, J. I., Gordon, J. I., Jansson, J. K., & Knight, R. (2012) · Nature · doi:10.1038/nature11550 · Cited by 5,533
Frank, D. N., St. Amand, A. L., Feldman, R. A., Boedeker, E. C., Harpaz, N., & Pace, N. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706625104 · Cited by 4,611
Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361
An ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
The Application of Ecological Theory Toward an Understanding of the Human Microbiome
Costello, E. K., Stagaman, K., Dethlefsen, L., Bohannan, B. J. M., & Relman, D. A. (2012) · Science · doi:10.1126/science.1224203 · Cited by 1,437
Metadata
- Authors
- Young, V. B., & Schmidt, T. M.
- Venue
- Journal of Clinical Microbiology
- Publisher
- American Society for Microbiology
- Published
- 2004-03
- Volume
- 42
- Issue
- 3
- Pages
- 1203-1206
- ISSN
- 0095-1137 (ISSN-L)
- 1098-660X
- OpenAlex
- W2140993771
- Cited by
- 335
- References
- 2
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- green
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- Young, V. B., & Schmidt, T. M. (2004). Antibiotic-Associated Diarrhea Accompanied by Large-Scale Alterations in the Composition of the Fecal Microbiota. Journal of Clinical Microbiology. https://doi.org/10.1128/jcm.42.3.1203-1206.2004
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