Cited by 135SARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections Studiesvaccines and immunoinformatics approaches

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Antigenic and Immunogenic Characterization of Recombinant Baculovirus-Expressed Severe Acute Respiratory Syndrome Coronavirus Spike Protein: Implication for Vaccine Design

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He, Yuxian, Li, Jingjing, Heck, Susanne, Lustigman, Sara, Jiang, Shibo·2006·Journal of Virology

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Abstract

The spike (S) glycoprotein of severe acute respiratory syndrome coronavirus (SARS-CoV) mediates the receptor interaction and immune recognition and is considered a major target for vaccine design. However, its antigenic and immunogenic properties remain to be elucidated. In this study, we immunized mice with full-length S protein (FL-S) or its extracellular domain (EC-S) expressed by recombinant baculoviruses in insect cells. We found that the immunized mice developed high titers of anti-S antibodies with potent neutralizing activities against SARS pseudoviruses constructed with the S proteins of Tor2, GD03T13, and SZ3, the representative strains of 2002 to 2003 and 2003 to 2004 human SARS-CoV and palm civet SARS-CoV, respectively. These data suggest that the recombinant baculovirus-expressed S protein vaccines possess excellent immunogenicity, thereby inducing highly potent neutralizing responses against human and animal SARS-CoV variants. The antigenic structure of the S protein was characterized by a panel of 38 monoclonal antibodies (MAbs) isolated from the immunized mice. The epitopes of most anti-S MAbs (32 of 38) were localized within the S1 domain, and those of the remaining 6 MAbs were mapped to the S2 domain. Among the anti-S1 MAbs, 17 MAbs targeted the N-terminal region (amino acids [aa] 12 to 327), 9 MAbs recognized the receptor-binding domain (RBD; aa 318 to 510), and 6 MAbs reacted with the C-terminal region of S1 domain that contains the major immunodominant si…

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Authors: He, Y., Li, J., Heck, S., Lustigman, S., & Jiang, S.
Affiliations: New York Blood Center (US)
Corresponding author: He, Yuxian
ORCID: He, Yuxian
Li, Jingjing
Heck, Susanne
Lustigman, Sara
Jiang, Shibo
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2006-06-15
Volume: 80
Issue: 12
Pages: 5757-5767
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.00083-06
OpenAlex: W2118619855
Cited by: 135
References: 55
Citations by year: 2026: 1 · 2024: 1 · 2023: 8 · 2022: 13 · 2021: 31 · 2020: 35 · 2019: 4 · 2018: 2 · 2017: 1 · 2015: 2 · 2014: 3 · 2013: 1 · 2012: 7
FWCI: 3.30
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords: SARS-CoV, spike protein, neutralizing antibodies, receptor binding domain, epitope mapping, monoclonal antibodies, conformational epitopes, S1 domain, S2 domain, antigen characterization, immunogenicity
MeSH terms: Animals, Antibodies, Monoclonal, Antibodies, Viral, Antibody Formation, Antigens, Viral, Cloning, Molecular, Humans, Immunization, Membrane Glycoproteins, Recombinant Proteins, Viral Envelope Proteins, Viral Vaccines, Baculoviridae, Epitope Mapping, Severe acute respiratory syndrome-related coronavirus, Mice, Spike Glycoprotein, Coronavirus

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Antigenic and Immunogenic Characterization of Recombinant Baculovirus-Expressed Severe Acute Respiratory Syndrome Coronavirus Spike Protein: Implication for Vaccine Design

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