The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice
Open accessAbstract
Airway macrophages provide a first line of host defense against a range of airborne pathogens, including influenza virus. In this study, we show that influenza viruses differ markedly in their abilities to infect murine macrophages in vitro and that infection of macrophages is nonproductive and no infectious virus is released. Virus strain BJx109 (H3N2) infected macrophages with high efficiency and was associated with mild disease following intranasal infection of mice. In contrast, virus strain PR8 (H1N1) was poor in its ability to infect macrophages and highly virulent for mice. Depletion of airway macrophages by clodronate-loaded liposomes led to the development of severe viral pneumonia in BJx109-infected mice but did not modulate disease severity in PR8-infected mice. The severe disease observed in macrophage-depleted mice infected with BJx109 was associated with exacerbated virus replication in the airways, leading to severe airway inflammation, pulmonary edema, and vascular leakage, indicative of lung injury. Thymic atrophy, lymphopenia, and dysregulated cytokine and chemokine production were additional systemic manifestations associated with severe disease. Thus, airway macrophages play a critical role in limiting lung injury and associated disease caused by BJx109. Furthermore, the inability of PR8 to infect airway macrophages may be a critical factor contributing to its virulence for mice.
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Cites
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Background
Cited by
Alveolar macrophages: plasticity in a tissue-specific context
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Macrophages: Development and Tissue Specialization
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The development and function of lung-resident macrophages and dendritic cells
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Pathogenesis of influenza-induced acute respiratory distress syndrome
Short, K. R., Kroeze, E. J. B. V., Fouchier, R. A. M., & Kuiken, T. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70286-x · Cited by 538
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Self-citation
Metadata
- Authors
- Tate, M. D., Pickett, D. L., van Rooijen, N., Brooks, A. G., & Reading, P. C.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-08
- Volume
- 84
- Issue
- 15
- Pages
- 7569-7580
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2007100673
- Cited by
- 227
- References
- 10
- FWCI
- 10.48
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
