The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter

Kao, Sandra; Miyagi, Eri; Mallorson, Rosa; Saito, Hideki; Sukegawa, Sayaka; Mukherji, Abhik; Mateja, Allyson; Ferhadian, Damien; Fabryova, Helena; Clouse, Kathleen; Strebel, Klaus

doi:10.1128/jvi.00652-22

The Myeloid-Specific Transcription Factor PU.1 Upregulates Mannose Receptor Expression but Represses Basal Activity of the HIV-LTR Promoter

HIV-1 replication in primary human cells depends on the activity of virus-encoded proteins but also involves cellular factors that can either promote (viral dependency factors) or inhibit (host restriction factors) virus replication. In previous work, we identified human MRC1 as a macrophage-spec…