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A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin
Open accessAbstract
The conserved influenza virus hemagglutinin (HA) stem domain elicits cross-reactive antibodies, but epitopes in the globular head typically elicit strain-specific responses because of the hypervariability of this region. We isolated human monoclonal antibody 5J8, which neutralized a broad spectrum of 20th century H1N1 viruses and the 2009 pandemic H1N1 virus. Fine mapping of the interaction unexpectedly revealed a novel epitope between the receptor-binding pocket and the Ca 2 antigenic site on HA. This antibody exposes a new mechanism underlying broad immunity against H1N1 influenza viruses and identifies a conserved epitope that might be incorporated into engineered H1 virus vaccines.
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Cites
Antibody Recognition of a Highly Conserved Influenza Virus Epitope
Ekiert, D. C., Bhabha, G., Elsliger, M.-A., Friesen, R. H. E., Jongeneelen, M., Throsby, M., Goudsmit, J., & Wilson, I. A. (2009) · Science · doi:10.1126/science.1171491 · Cited by 1,326
Cited by
Reverse vaccinology 2.0: Human immunology instructs vaccine antigen design
Rappuoli, R., Bottomley, M. J., D’Oro, U., Finco, O., & De Gregorio, E. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151960 · Cited by 435
O’Donnell, C. D., Vogel, L., Wright, A., Das, S. R., Wrammert, J., Li, G.-M., McCausland, M., Zheng, N.-Y., Yewdell, J. W., Ahmed, R., et al. (2012) · mBio · doi:10.1128/mbio.00120-12 · Cited by 77
Formatted single-domain antibodies can protect mice against infection with influenza virus (H5N2)
Tillib, S. V., Ivanova, T. I., Vasilev, L. A., Rutovskaya, M. V., Saakyan, S. A., Gribova, I. Y., Tutykhina, I. L., Sedova, E. S., Lysenko, A. A., Shmarov, M. M., et al. (2013) · Antiviral Research · doi:10.1016/j.antiviral.2012.12.014 · Cited by 54
Chen, Z.-S., Huang, H.-C., Wang, X., Schön, K., Jia, Y., Lebens, M., Besavilla, D. F., Murti, J. R., Ji, Y., Sarshad, A. A., et al. (2025) · Nature Communications · doi:10.1038/s41467-024-55193-y · Cited by 39
Triple tandem trimer immunogens for HIV-1 and influenza nucleic acid-based vaccines
del Moral-Sánchez, I., Wee, E. G., Xian, Y., Lee, W.-H., Allen, J. D., Torrents de la Peña, A., Fróes Rocha, R., Ferguson, J., León, A. N., Koekkoek, S., et al. (2024) · npj Vaccines · doi:10.1038/s41541-024-00862-8 · Cited by 14
Metadata
- Authors
- Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Basler, C. F., & Crowe, J. E.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2011-10-15
- Volume
- 85
- Issue
- 20
- Pages
- 10905-10908
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2061221862
- Cited by
- 204
- References
- 1
- FWCI
- 13.18
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin. https://app.cochat.ai/papers/10.1128/jvi.00700-11
- The paper
- Krause, J. C., Tsibane, T., Tumpey, T. M., Huffman, C. J., Basler, C. F., & Crowe, J. E. (2011). A Broadly Neutralizing Human Monoclonal Antibody That Recognizes a Conserved, Novel Epitope on the Globular Head of the Influenza H1N1 Virus Hemagglutinin. Journal of Virology. https://doi.org/10.1128/jvi.00700-11
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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