Cited by 282HIV Research and TreatmentLipid Membrane Structure and BehaviorCellular transport and secretion

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Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides

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Chan, Robin, Uchil, Pradeep D., Jin, Jing, Shui, Guanghou, Ott, David E., Mothes, Walther, Wenk, Markus R.·2008·Journal of Virology

DOI 10.1128/jvi.00981-08PMC PMC2573248

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Abstract

Retroviruses acquire a lipid envelope during budding from the membrane of their hosts. Therefore, the composition of this envelope can provide important information about the budding process and its location. Here, we present mass spectrometry analysis of the lipid content of human immunodeficiency virus type 1 (HIV-1) and murine leukemia virus (MLV). The results of this comprehensive survey found that the overall lipid content of these viruses mostly matched that of the plasma membrane, which was considerably different from the total lipid content of the cells. However, several lipids are enriched in comparison to the composition of the plasma membrane: (i) cholesterol, ceramide, and GM3; and (ii) phosphoinositides, phosphorylated derivatives of phosphatidylinositol. Interestingly, microvesicles, which are similar in size to viruses and are also released from the cell periphery, lack phosphoinositides, suggesting a different budding mechanism/location for these particles than for retroviruses. One phosphoinositide, phosphatidylinositol 4,5-bisphosphate [PI(4,5)P 2 ], has been implicated in membrane binding by HIV Gag. Consistent with this observation, we found that PI(4,5)P 2 was enriched in HIV-1 and that depleting this molecule in cells reduced HIV-1 budding. Analysis of mutant virions mapped the enrichment of PI(4,5)P 2 to the matrix domain of HIV Gag. Overall, these results suggest that HIV-1 and other retroviruses bud from cholesterol-rich regions of the plasma membrane and exploit matrix/PI(4,5)P 2 interactions for particle release from cells.

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Authors: Chan, R., Uchil, P. D., Jin, J., Shui, G., Ott, D. E., Mothes, W., & Wenk, M. R.
Affiliations: National University of Singapore (SG)
Yale University (US)
National Cancer Institute (US)
Corresponding author: Wenk, Markus R.
ORCID: Chan, Robin
Uchil, Pradeep D.
Jin, Jing
Shui, Guanghou
Mothes, Walther
Wenk, Markus R.
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2008-11-15
Volume: 82
Issue: 22
Pages: 11228-11238
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.00981-08
PMC: PMC2573248
OpenAlex: W2081618928
Cited by: 282
References: 65
Citations by year: 2026: 4 · 2025: 4 · 2024: 10 · 2023: 8 · 2022: 9 · 2021: 13 · 2020: 10 · 2019: 12 · 2018: 12 · 2017: 7 · 2016: 18 · 2015: 20 · 2014: 23 · 2013: 26 · 2012: 31
FWCI: 8.34
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
National University of Singapore (submittedVersion)
Funders: National University of Singapore
National Institutes of Health (n01co12400-79-0-22)
Biomedical Research Council
National Cancer Institute (N01-CO-012400, ND1-CO-12400, R01CA098727)
National Institute of Allergy and Infectious Diseases (R21AI065284)
H2020 European Research Council
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Keywords: retroviruses, HIV-1, murine leukemia virus, phosphoinositides, phosphatidylinositol 4,5-bisphosphate, viral budding, plasma membrane, cholesterol, ceramide, GM3 ganglioside, microvesicles, HIV Gag, matrix domain, membrane binding
MeSH terms: Animals, Cell Line, Cell Membrane, Cytoplasm, Humans, Lipids, Leukemia Virus, Murine, Phosphatidylinositols, Mass Spectrometry, HIV-1, Secretory Vesicles, Rats, gag Gene Products, Human Immunodeficiency Virus

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Retroviruses Human Immunodeficiency Virus and Murine Leukemia Virus Are Enriched in Phosphoinositides

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