Cited by 129HIV Research and TreatmentT-cell and Retrovirus StudiesHIV/AIDS drug development and treatment

Molecular determinants that regulate plasma membrane association of HIV-1 Gag

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Chukkapalli, Vineela, Ono, Akira·2011·Journal of Molecular Biology

Abstract

Human immunodeficiency virus type 1 assembly is a multistep process that occurs at the plasma membrane (PM). Targeting and binding of Gag to the PM are the first steps in this assembly process and are mediated by the matrix domain of Gag. This review highlights our current knowledge on viral and cellular determinants that affect specific interactions between Gag and the PM. We will discuss potential mechanisms by which the matrix domain might integrate three regulatory components, myristate, phosphatidylinositol-(4,5)-bisphosphate, and RNA, to ensure that human immunodeficiency virus type 1 assembly occurs at the PM.

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Crossref · 10.1016/j.jmb.2011.04.015

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  • The MA domain contains a highly basic region essential for regulating Gag relocalization to the plasma membrane by specifically interacting with phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2).

    “The MA domain contains a highly basic region essential for regulating Gag relocalization to the plasma membrane by specifically interacting with phosphatidylinositol 4,5bisphosphate (PI(4,5)P 2 ) (77).”

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  1. [93]Sherer NM Swanson CM Papaioannou S Malim MH 2009 Matrix Mediates the Functional Link between Hiv-1 Rna Nuclear Export Elements and Gag Assembly Competency in Murine Cells J Virol PMC2738188 19535446

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Authors
Chukkapalli, V., & Ono, A.
Affiliations
University of Michigan (US)
Corresponding author
Ono, Akira
Venue
Journal of Molecular Biology
Publisher
Elsevier BV
Published
2011-07
Volume
410
Issue
4
Pages
512-524
ISSN
0022-2836 (ISSN-L)
OpenAlex
W1982692592
Cited by
129
References
121
Citations by year
2026: 3 · 2025: 3 · 2024: 8 · 2023: 1 · 2022: 5 · 2021: 8 · 2020: 10 · 2019: 11 · 2018: 12 · 2017: 8 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 12 · 2012: 11
FWCI
1.81
Type
journal article
Language
en
Open access
Locations
  • Journal of Molecular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R56AI089282, R01AI071727)
Topics
  • Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and Retrovirus Studies
  • Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
Keywords
HIV-1, Gag, matrix domain, plasma membrane association, viral assembly, myristoylation, phosphatidylinositol 4,5-bisphosphate, RNA binding, membrane targeting
MeSH terms
Amino Acid Sequence, Cell Membrane, Humans, Membrane Lipids, Molecular Sequence Data, Protein Binding, Viral Matrix Proteins, HIV-1, gag Gene Products, Human Immunodeficiency Virus

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