Siglec-1 Is a Novel Dendritic Cell Receptor That Mediates HIV-1 Trans-Infection Through Recognition of Viral Membrane Gangliosides
Open accessAbstract
Dendritic cells (DCs) are essential antigen-presenting cells for the induction of immunity against pathogens. However, HIV-1 spread is strongly enhanced in clusters of DCs and CD4(+) T cells. Uninfected DCs capture HIV-1 and mediate viral transfer to bystander CD4(+) T cells through a process termed trans-infection. Initial studies identified the C-type lectin DC-SIGN as the HIV-1 binding factor on DCs, which interacts with the viral envelope glycoproteins. Upon DC maturation, however, DC-SIGN is down-regulated, while HIV-1 capture and trans-infection is strongly enhanced via a glycoprotein-independent capture pathway that recognizes sialyllactose-containing membrane gangliosides. Here we show that the sialic acid-binding Ig-like lectin 1 (Siglec-1, CD169), which is highly expressed on mature DCs, specifically binds HIV-1 and vesicles carrying sialyllactose. Furthermore, Siglec-1 is essential for trans-infection by mature DCs. These findings identify Siglec-1 as a key factor for HIV-1 spread via infectious DC/T-cell synapses, highlighting a novel mechanism that mediates HIV-1 dissemination in activated tissues.
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Siglec-1 is expressed on activated mature DCs and macrophages and binds to GM3 ganglioside in the HIV-1 viral envelope.
“This receptor is expressed on the surface of activated mature DCs and macrophages, and binds to the GM3 ganglioside in the HIV-1 viral envelope [85,86,87].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [86]
The Results report increased surface expression of Siglec-1 on LPS-matured DCs, and the Discussion describes its expression in tissue macrophages. The paper also shows Siglec-1-dependent HIV-1 capture through recognition of viral membrane gangliosides, but the relevant Results passage tests GM1-containing model vesicles; our copy does not establish binding specifically to GM3 in the HIV-1 envelope. (LLM, conf=0.86)
Experimental — accuracy not yet measuredCD169/Siglec-1 mediates uptake and transmission of HIV-1.
“Another molecule that mediates the uptake and transmission of HIV-1 is the type I lectin receptor CD169/sialic acid-binding immunoglobulin-type lectin 1 (Siglec-1).”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [86]
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“Interestingly, Siglec-1 interacting with viral membrane gangliosides also mediates trans-infection with HIV (Izquierdo-Useros et al., 2012).”
BackgroundAffandi, A. J., Grabowska, J. A., Olesek, K., Venegas, M. L., Barbaria, A., Rodríguez, E., Mulder, P. P. G., Pijffers, H. J., Ambrosini, M., Kalay, H., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2006186117 · Cited by 88 · see citing works
Akiyama, H., Ramirez, N.-G. P., Gudheti, M. V., & Gummuluru, S. (2015) · PLOS Pathogens · doi:10.1371/journal.ppat.1004751 · Cited by 79 · see citing works
“5B and C) and CD169—HIV-1 interaction is a protein (CD169)—lipid (GM3) interaction [13,14,38,39].”
BackgroundResultInfluentialCell-to-cell spread of HIV-1 and evasion of neutralizing antibodies
Schiffner, T., Sattentau, Q. J., & Duncan, C. J. A. (2013) · Vaccine · doi:10.1016/j.vaccine.2013.10.020 · Cited by 78 · see citing works
Agosto, L. M., Herring, M. B., Mothes, W., & Henderson, A. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.079 · Cited by 77 · see citing works
Yu, X., Feizpour, A., Ramirez, N.-G. P., Wu, L., Akiyama, H., Xu, F., Gummuluru, S., & Reinhard, B. M. (2014) · Nature Communications · doi:10.1038/ncomms5136 · Cited by 77 · see citing works
Mechanisms of HIV-1 cell-to-cell transmission and the establishment of the latent reservoir
Pedro, K. D., Henderson, A. J., & Agosto, L. M. (2019) · Virus Research · doi:10.1016/j.virusres.2019.03.014 · Cited by 74 · see citing works
“HIV-1 is captured by APC surface molecules, such as the C-type lectin SIGLEC-1, and retained within non-lysosomal compartments where it avoids degradation and antibody neutralization (Gummuluru et al., 2014; Izquierdo-Useros et al., 2012; Puryear et al., 2013; Puryear et al., 2012; Waki and Freed, 2010).”
BackgroundLipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation
Xu, F., Reiser, M. L., Yu, X., Gummuluru, S., Wetzler, L. M., & Reinhard, B. M. (2015) · ACS Nano · doi:10.1021/acsnano.5b06501 · Cited by 76 · see citing works
HIV-1 cell-to-cell transmission and broadly neutralizing antibodies
Dufloo, J., Bruel, T., & Schwartz, O. (2018) · Retrovirology · doi:10.1186/s12977-018-0434-1 · Cited by 69 · see citing works
Comparative analysis of human microglial models for studies of HIV replication and pathogenesis
Mohammad, A., Hammonds, J. E., Pujato, M. A., Mayhew, C. N., Roskin, K. M., & Spearman, P. W. (2020) · Retrovirology · doi:10.1186/s12977-020-00544-y · Cited by 72 · see citing works
Saad, M. H., Badierah, R., Redwan, E. M. M. M., & El‐Fakharany, E. M. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13091405 · Cited by 71 · see citing works
“[75] revealed that HIV-1 sorts all particles and antigens in exosome-like vesicles after fusing with DCs uses.”
BackgroundChiodo, F., Bruijns, S. C. M., Rodríguez, E., Li, R. J. E., Molinaro, A., Silipo, A., Lorenzo, F. D., García-Rivera, D., Valdés-Balbín, Y., Vérez-Bencomo, V. G., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.13.092478 · Cited by 73 · see citing works
Dupont, M., Souriant, S., Balboa, L., Manh, T. V., Pingris, K., Rousset, S., Cougoule, C., Rombouts, Y., Poincloux, R., Ben-Neji, M., et al. (2020) · eLife · doi:10.7554/elife.52535 · Cited by 68 · see citing works
“…in HIV-1 transfer from myeloid cells to T cells, as well as in the initiation of virus-containing compartment (VCC) formation in macrophages (Izquierdo-Useros et al., 2012a; Izquierdo-Useros et al., 2012b; Puryear et al., 2013; Puryear et al., 2012), and in the viral dissemination in vivo…”
BackgroundMethodInfluentialSelf-citationHIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread
Kalinichenko, S., Komkov, D., & Mazurov, D. (2022) · Viruses · doi:10.3390/v14010152 · Cited by 68 · see citing works
Anti-Siglec-1 antibodies block Ebola viral uptake and decrease cytoplasmic viral entry
Perez‐Zsolt, D., Erkizia, I., Pino, M., Garcı́a-Gallo, M., Martin, M. T., Benet, S., Chojnacki, J., Fernández‐Figueras, M. T., Guerrero, D., Urrea, V., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0453-2 · Cited by 68 · see citing works
Self-citationCD169 Defines Activated CD14+ Monocytes With Enhanced CD8+ T Cell Activation Capacity
Affandi, A. J., Olesek, K., Grabowska, J. A., Twilhaar, M. K. N., Rodríguez, E., Saris, A., Zwart, E. S., Nossent, E. J., Kalay, H., de Kok, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.697840 · Cited by 67 · see citing works
de Oliveira, J. J., Karrar, S., Rainbow, D. B., Pinder, C. L., Pamela, C., García, A. R., Al‐Assar, O., Burling, K., Morris, S., Stratton, R. J., et al. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1649-1 · Cited by 66 · see citing works
NK Cell Subset Redistribution during the Course of Viral Infections
Lugli, E., Marcenaro, E., & Mavilio, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00390 · Cited by 65 · see citing works
Lectin Receptors Expressed on Myeloid Cells
Brown, G. D., & Crocker, P. R. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0036-2016 · Cited by 66 · see citing works
“CD169 macrophage capture of viruses is important for restraining viral spread to distal sites (28), but it can also promote viral transfer to neighboring cells such as T cells (29, 30) and B cells (31) and directly prime CD8 cytotoxic T cells for responses to viral antigens via crosspresentation (27).”
BackgroundCD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses
Jalloh, S., Olejnik, J., Berrigan, J. L., Nisa, A., Suder, E. L., Akiyama, H., Lei, M., Ramaswamy, S., Tyagi, S., Bushkin, Y., et al. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010479 · Cited by 64 · see citing works
Immune Responses to Retroviruses
Sáez‐Cirión, A., & Manel, N. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052155 · Cited by 64 · see citing works
“MDDCs that are treated with type I IFN express SIGLEC-1, which can also capture viral particles and contribute to T cell infection (67).”
BackgroundWoodham, A. W., Skeate, J. G., Sanna, A. M., Taylor, J. R., Silva, D. M. D., Cannon, P. M., & Kast, W. M. (2016) · AIDS Patient Care and STDs · doi:10.1089/apc.2016.0100 · Cited by 62 · see citing works
“Another C-type lectin receptor similar to DC-SIGN that can act as an attachment factor for HIV is the DC immunoreceptor (DCIR), although recently it was shown that DC-SIGN played a stronger role than DCIR in trans-infection of a broader range of isolates.197 Moreover, DC-SIGN is downregulated upon DC activation, while…”
BackgroundInfluentialMucosal stromal fibroblasts markedly enhance HIV infection of CD4+ T cells
Neidleman, J. A., Chen, J. C., Kohgadai, N., Müller, J. A., Laustsen, A., Thavachelvam, K., Jang, K. S., Stürzel, C. M., Jones, J. J., Ochsenbauer, C., et al. (2017) · PLoS Pathogens · doi:10.1371/journal.ppat.1006163 · Cited by 62 · see citing works
Dendritic Cells, the Double Agent in the War Against HIV-1
Martín-Moreno, A., & Muñoz‐Fernández, M. Á. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02485 · Cited by 61 · see citing works
Delivery of microRNAs by Extracellular Vesicles in Viral Infections: Could the News be Packaged?
Yoshikawa, F. S. Y., Teixeira, F. M. E., Sato, M. N., & Oliveira, L. M. D. S. (2019) · Cells · doi:10.3390/cells8060611 · Cited by 60 · see citing works
“There is some evidence that human immunodeficiency virus (HIV) can utilize dendritic cell-to-T cell vesicle transfer as an alternative route for productive infection, a mechanism called transinfection, which may also be utilized by certain types of EVs [27].”
BackgroundAntigen structure affects cellular routing through DC-SIGN
Jarvis, C. M., Zwick, D. B., Grim, J. C., Alam, M. M., Prost, L. R., Gardiner, J. C., Park, S., Zimdars, L. L., Sherer, N. M., & Kiessling, L. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820165116 · Cited by 59 · see citing works
“Similarly, Siglec-1 (12), another DC lectin, is implicated in facilitating HIV-1 trans infection of T cells (13).”
BackgroundYahi, N., & Fantini, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0104751 · Cited by 58 · see citing works
microRNA exchange via extracellular vesicles in cancer
Vu, L. T., Gong, J., Pham, T. T., Kim, Y., & Le, M. T. N. (2020) · Cell Proliferation · doi:10.1111/cpr.12877 · Cited by 55 · see citing works
Antiviral mechanism of polyanionic carbosilane dendrimers against HIV-1
Muñoz‐Fernández, M. Á., Vacas‐Córdoba, E., Maly, M., de la Mata, F. J., Gómez, R., & Pion, M. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s96352 · Cited by 56 · see citing works
Dendritic Cells From the Cervical Mucosa Capture and Transfer HIV-1 via Siglec-1
Perez-Zsolt, D., Cantero-Pérez, J., Erkizia, I., Benet, S., Pino, M., Serra-Peinado, C., Hernández-Gallego, A., Castellví, J., Tapia, G., Arnau-Saz, V., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00825 · Cited by 52 · see citing works
“However, it does not bind to the envelope glycoprotein of HIV-1 as C-type lectin receptors do (11), but recognizes sialylated gangliosides that are anchored on the viral membrane of enveloped retroviruses (19, 26).”
BackgroundMethodInfluentialSelf-citationDutartre, H., Clavière, M., Journo, C., & Mahieux, R. (2016) · Journal of Virology · doi:10.1128/jvi.00407-16 · Cited by 55 · see citing works
“Siglec-1 colocalizes with HIV-1 in sac-like compartments and accumulates at the infectious synapse when LPS-matured MDDCs are cocultured with T cells (122, 132, 133), further demonstrating that DC-mediated trans-infection of T cells relies on Siglec-1.”
BackgroundResultInfluentialInterferon-Inducible CD169/Siglec1 Attenuates Anti-HIV-1 Effects of Alpha Interferon
Akiyama, H., Ramirez, N.-G. P., Gibson, G. A., Kline, C. E., Watkins, S. C., Ambrose, Z., & Gummuluru, S. (2017) · Journal of Virology · doi:10.1128/jvi.00972-17 · Cited by 54 · see citing works
“In contrast, CD169/Siglec1 is encoded by an ISG whose expression is induced on myeloid DCs upon IFN- treatment (31) and has been previously shown to enhance HIV-1 replication by targeting captured virus particles to the DC-mediated trans-infection pathway (31, 32).”
BackgroundResultInfluentialRuffin, N., Gea‐Mallorquí, E., Brouiller, F., Jouve, M. J., Silvin, A., See, P., Dutertre, C., Ginhoux, F., & Benaroch, P. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1911007116 · Cited by 50 · see citing works
Interferon epsilon promotes HIV restriction at multiple steps of viral replication
Minambres, A. G., Eid, S. G., Mangan, N. E., Pade, C., Lim, S. S., Matthews, A. Y., de Weerd, N. A., Hertzog, P. J., & Mak, J. (2017) · Immunology and Cell Biology · doi:10.1038/icb.2016.123 · Cited by 49 · see citing works
Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation
Büll, C., Camps, E. C., Kers‐Rebel, E. D., Heise, T., Søndergaard, J. N., den Brok, M. H., Schulte, B. M., Boltje, T. J., & Adema, G. J. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.105 · Cited by 48 · see citing works
Tolerance in Organ Transplantation: From Conventional Immunosuppression to Extracellular Vesicles
Tortajada, M., Lauzurica, R., & Borràs, F. E. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00416 · Cited by 47 · see citing works
CD169 is a marker for highly pathogenic phagocytes in multiple sclerosis
Bogie, J. F. J., Boelen, E., Louagie, E., Delputte, P., Elewaut, D. S., van Horssen, J., Hendriks, J. J. A., & Hellings, N. (2017) · Multiple Sclerosis Journal · doi:10.1177/1352458517698759 · Cited by 47 · see citing works
HIV-1 Trans Infection of CD4 + T Cells by Professional Antigen Presenting Cells
Rinaldo, C. R. (2013) · Scientifica · doi:10.1155/2013/164203 · Cited by 46 · see citing works
Guardo, A. C., Joe, P. T., Miralles, L., Bargalló, M. E., Mothe, B., Krasniqi, A., Heirman, C., García, F., Thielemans, K., Brander, C., et al. (2016) · AIDS · doi:10.1097/qad.0000000000001276 · Cited by 46 · see citing works
“Further and related with the evaluation of maturation markers, we observed that CD169/Siglec-1, which is involved in transinfection of HIV, [47] was also upregulated.”
BackgroundProteomics study of human cord blood reticulocyte-derived exosomes
Díaz-Varela, M., Menezes‐Neto, A., Perez‐Zsolt, D., Gámez‐Valero, A., Seguí-Barber, J., Izquierdo‐Useros, N., Martínez‐Picado, J., Fernández-Becerra, C., & Portillo, H. A. D. (2018) · Scientific Reports · doi:10.1038/s41598-018-32386-2 · Cited by 46 · see citing works
Self-citationKlein, K., Veazey, R. S., Warrier, R., Hraber, P., Doyle‐Meyers, L. A., Buffa, V., Liao, H., Haynes, B. F., Shaw, G. M., & Shattock, R. J. (2013) · Journal of Virology · doi:10.1128/jvi.01361-13 · Cited by 44 · see citing works
“Therefore, we assessed the inhibitory activity of 2F5 IgG, IgA, IgM, and Fab in MDDCs.”
BackgroundInfluentialLabeling of virus components for advanced, quantitative imaging analyses
Sakin, V., Paci, G., Lemke, E. A., & Müller, B. (2016) · FEBS Letters · doi:10.1002/1873-3468.12131 · Cited by 44 · see citing works
Mikulak, J., Vito, C. D., Zaghi, E., & Mavilio, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00314 · Cited by 44 · see citing works
“Indeed, the masking of Siglec-7 greatly reduce the amount of HIV-RNA in MDMs, thus decreasing their susceptibility to infection (52) (Figure 1).”
BackgroundInfluentialVarchetta, S., Lusso, P., Hudspeth, K. L., Mikulak, J., Mele, D., Paolucci, S., Cimbro, R., Malnati, M., Riva, A., Maserati, R., et al. (2013) · Retrovirology · doi:10.1186/1742-4690-10-154 · Cited by 44 · see citing works
“Furthermore, it has recently been shown that different Siglecs, and Siglec-1 in particular, are able to recognize both R5 and X4 HIV-1 gp120 through interaction with sialic acids, thus contributing to HIV-1 infection of monocytes, macrophages and DCs [28-30].”
InfluentialSiglecs at the Host–Pathogen Interface
Chang, Y., & Nizet, V. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-1580-4_8 · Cited by 43 · see citing works
“Host cellderived α2,3 sialylated glycosphingolipid (GSL) on the HIV-1 particle membrane is the ligand for Siglec-1 on mDC required for triggering mDC-mediated transinfection of CD4+ T cells in lymphoid organs (Yu et al. 2014; Izquierdo-Useros et al. 2012; Puryear et al. 2013).”
BackgroundAkiyama, H., Miller, C., Patel, H., Hatch, S., Archer, J., Ramirez, N.-G. P., & Gummuluru, S. (2014) · Journal of Virology · doi:10.1128/jvi.00992-14 · Cited by 41 · see citing works
“Furthermore, GM3 incorporation has been shown to be critical for CD169-dependent HIV-1 capture by mature DCs (14, 16).”
BackgroundMethodHow dendritic cells sense and respond to viral infections
Marongiu, L., Valache, M., Facchini, F. A., & Granucci, F. (2021) · Clinical Science · doi:10.1042/cs20210577 · Cited by 41 · see citing works
“136 Izquierdo-Useros, N. et al. (2012) Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.”
BackgroundT-Cell Signaling in HIV-1 Infection
Abbas, W., & Herbein, G. (2013) · The Open Virology Journal · doi:10.2174/1874357920130621001 · Cited by 38 · see citing works
CD169-Dependent Cell-Associated HIV-1 Transmission: A Driver of Virus Dissemination
Gummuluru, S., Ramirez, N.-G. P., & Akiyama, H. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu442 · Cited by 42 · see citing works
“conjugates resulted in colocalization of CD169-bound HIV-1 particles at the DC–T-cell virological synapse (Figure 1) [29, 49].”
BackgroundStructural advances of Siglecs: insight into synthetic glycan ligands for immunomodulation
Movsisyan, L. D., & Macauley, M. S. (2020) · Organic & Biomolecular Chemistry · doi:10.1039/d0ob01116a · Cited by 42 · see citing works
Human Blood-Circulating Basophils Capture HIV-1 and Mediate Viraltrans-Infection of CD4+T Cells
Jiang, A., Jiang, J., Guo, M., Jin, Y., Li, Y., & Wang, J. (2015) · Journal of Virology · doi:10.1128/jvi.01021-15 · Cited by 40 · see citing works
Lassa and Marburg viruses elicit distinct host transcriptional responses early after infection
Caballero, I. S., Yen, J. Y., Hensley, L. E., Honko, A. N., Goff, A. J., & Connor, J. H. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-960 · Cited by 40 · see citing works
“…genes with distinctly upregulated expression (Figure 3 and Additional file 1), including SIGLEC1, a cell adhesion molecule expressed by dendritic cells and macrophages [24,25]; SAMD4, a translational repressor [26]; and TNK2, a tyrosine kinase implicated in cell spreading and migration [27].”
Possible Influences of Endogenous and Exogenous Ligands on the Evolution of Human Siglecs
Angata, T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02885 · Cited by 40 · see citing works
Productive HIV-1 infection of tissue macrophages by fusion with infected CD4+ T cells
Mascarau, R., Woottum, M., Fromont, L., Gence, R., Cantaloube-Ferrieu, V., Vahlas, Z., Lévêque, K., Bertrand, F., Beunon, T., Métais, A., et al. (2023) · The Journal of Cell Biology · doi:10.1083/jcb.202205103 · Cited by 39 · see citing works
“…establishment of the virological (Jolly et al., 2004; Jolly et al., 2007a; Jolly et al., 2007b; Jolly and Sattentau, 2007) and infectious synapses (Izquierdo-Useros et al., 2012; Menager and Littman, 2016; Nikolic et al., 2011) that allow cis - and trans - infection, respectively, or the…”
Identification of Siglec-1 null individuals infected with HIV-1
Martínez‐Picado, J., McLaren, P. J., Erkizia, I., Martin, M. P., Benet, S., Rotger, M., Dalmau, J., Ouchi, D., Wolinsky, S. M., Penugonda, S., et al. (2016) · Nature Communications · doi:10.1038/ncomms12412 · Cited by 38 · see citing works
Self-citationGlycan Chains of Gangliosides: Functional Ligands for Tissue Lectins (Siglecs/Galectins)
Ledeen, R. W., Kopitz, J., Abad‐Rodríguez, J., & Gabius, H. (2018) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2017.12.004 · Cited by 36 · see citing works
Masters of manipulation: Viral modulation of the immunological synapse
Bayliss, R. J., & Piguet, V. (2018) · Cellular Microbiology · doi:10.1111/cmi.12944 · Cited by 35 · see citing works
Kaddour, H., Panzner, T. D., Welch, J. L., Shouman, N., Mohan, M., Stapleton, J. T., & Okeoma, C. M. (2020) · Viruses · doi:10.3390/v12101117 · Cited by 35 · see citing works
“Viral sialic acids also interact with Siglec-1 on host monocytes/macrophage and dendritic cells [79,80], and Siglec-1 mediates macrophage to CD4+ T cell HIV transmission [81].”
BackgroundPrenzler, S., Rudrawar, S., Waespy, M., Kelm, S., Anoopkumar‐Dukie, S., & Haselhorst, T. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.1931171 · Cited by 38 · see citing works
“This occurs when portions of the glycocalyx containing GM3 sialic acid containing gangliosides are removed to create the viral envelope [61, 62].”
BackgroundMetabolisches Glykoengineering mit N‐Acyl‐Seiten‐ ketten‐modifizierten Mannosaminen
Wratil, P. R., Horstkorte, R., & Reutter, W. G. (2016) · Angewandte Chemie · doi:10.1002/ange.201601123 · Cited by 33 · see citing works
Saini, P., Adeniji, O. S., & Abdel‐Mohsen, M. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.104354 · Cited by 32 · see citing works
Cell-to-Cell Spread of HIV and Viral Pathogenesis
Law, K., Satija, N., Esposito, A. M., & Chen, B. K. (2016) · Advances in virus research · doi:10.1016/bs.aivir.2016.03.001 · Cited by 32 · see citing works
“Siglec-1 (CD169) is a cell surface receptor that mediates trans-enhancement of HIV infection through recognition of sialic acid moieties of glycosphingolipids in virus membrane (Izquierdo-Useros et al., 2012).”
Backgroundvan Dinther, D., Venegas, M. L., Veninga, H., Olesek, K., Hoogterp, L., Revet, M., Ambrosini, M., Kalay, H., Stöckl, J., van Kooyk, Y., et al. (2019) · Cancers · doi:10.3390/cancers11020183 · Cited by 32 · see citing works
Grabowska, J. A., Affandi, A. J., van Dinther, D., Twilhaar, M. K. N., Olesek, K., Hoogterp, L., Ambrosini, M., Heijnen, D. A. M., Klaase, L., Hidalgo, A., et al. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.01.029 · Cited by 32 · see citing works
“Our results demonstrating enhanced targeting of GM3 liposomes to CD169+ macrophages in vivo are in line with human in vitro studies using GM3-containing nanoparticles, which reported specific binding to human CD169-expressing macrophages and monocyte-derived DCs [20,22,65].”
ResultInfluentialOstendorf, L., Dittert, P., Biesen, R., Duchow, A. S., Stiglbauer, V., Ruprecht, K., Bellmann–Strobl, J., Seelow, D., Stenzel, W., Niesner, R. A., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-89786-0 · Cited by 32 · see citing works
“Additional immune-mediated diseases (n) Autoimmune thyroiditis (2), asthma bronchiale (1) Autoimmune thyroiditis (10), asthma bronchiale (2), psoriasis (1), idiopathic myocarditis (1), celiac disease (1) Autoimmune thyroiditis (3), myasthenia gravis (1), Sjögren syndrome (1), MCTD (1)”
BackgroundMa, T., McGregor, M. M., Giron, L. B., Xie, G., George, A. F., Abdel‐Mohsen, M., & Roan, N. R. (2022) · eLife · doi:10.7554/elife.78870 · Cited by 32 · see citing works
Perez‐Zsolt, D., Martínez‐Picado, J., & Izquierdo‐Useros, N. (2019) · Viruses · doi:10.3390/v12010008 · Cited by 31 · see citing works
“This result has been confirmed not only in vitro [63,127] with extracellular vesicles derived from cell lines or primary cells but also in murine models where Siglec-1 expressed on lymphoid tissues was required to trap extracellular vesicles in vivo [128].”
BackgroundResultInfluentialSelf-citationMurakami, T., Kim, J.-W., Li, Y., Green, G. E., Shikanov, A., & Ono, A. (2018) · Nature Communications · doi:10.1038/s41467-018-04846-w · Cited by 31 · see citing works
- Authors
- Izquierdo-Useros, N., Lorizate, M., Puertas, M. C., Rodriguez-Plata, M. T., Zangger, N., Erikson, E., Pino, M., Erkizia, I., Glass, B., Clotet, B., Keppler, O. T., Telenti, A., Kräusslich, H.-G., & Martinez-Picado, J.
- Affiliations
- University Hospital Heidelberg (DE)
- Universitat Autònoma de Barcelona (ES)
- Centre Hospitalier Universitaire Vaudois (CH)
- Corresponding author
- Kräusslich, Hans-Georg
- ORCID
- Venue
- PLoS Biology
- Publisher
- Public Library of Science (PLoS)
- Published
- 2012-12-18
- Volume
- 10
- Issue
- 12
- Pages
- e1001448
- ISSN
- 1544-9173 (ISSN-L)
- 1545-7885
- PMC
- PMC3525531
- OpenAlex
- W2035871823
- Cited by
- 244
- References
- 44
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 11 · 2023: 11 · 2022: 20 · 2021: 22 · 2020: 19 · 2019: 22 · 2018: 23 · 2017: 21 · 2016: 26 · 2015: 15 · 2014: 14 · 2013: 17 · 2012: 1
- FWCI
- 6.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- PLoS Biology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Dipòsit Digital de Documents de la UAB (Universitat Autònoma de Barcelona) (submittedVersion, cc-by)
- IRIS (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- SERVAL (Université de Lausanne) (submittedVersion, other-oa)
- Funders
- National Science Foundation
- Styrelsen för Internationellt Utvecklingssamarbete
- Deutsche Forschungsgemeinschaft (EXC 81, TRR 83)
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (132863)
- Ministerio de Ciencia e Innovación (SAF2010-21224)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- Siglec-1, CD169, dendritic cells, sialyllactose, sialic acid-binding lectins, DC-SIGN, viral dissemination, DC maturation, CD4+ T cells
- MeSH terms
- Dendritic Cells, Gangliosides, Humans, Lipid Bilayers, Lipopolysaccharides, Liposomes, Virion, HIV-1, HIV Infections, Up-Regulation, Gene Silencing, Immunological Synapses, Exosomes, HEK293 Cells, Sialic Acid Binding Ig-like Lectin 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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