The DOI matches its Crossref record; 74 of the 74 references it cites were found in a registry or an index.
Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry
Open accessAbstract
The cell surface receptor T cell immunoglobulin mucin domain 1 (TIM-1) dramatically enhances filovirus infection of epithelial cells. Here, we showed that key phosphatidylserine (PtdSer) binding residues of the TIM-1 IgV domain are critical for Ebola virus (EBOV) entry through direct interaction with PtdSer on the viral envelope. PtdSer liposomes but not phosphatidylcholine liposomes competed with TIM-1 for EBOV pseudovirion binding and transduction. Further, annexin V (AnxV) substituted for the TIM-1 IgV domain, supporting a PtdSer-dependent mechanism. Our findings suggest that TIM-1-dependent uptake of EBOV occurs by apoptotic mimicry. Additionally, TIM-1 enhanced infection of a wide range of enveloped viruses, including alphaviruses and a baculovirus. As further evidence of the critical role of enveloped-virion-associated PtdSer in TIM-1-mediated uptake, TIM-1 enhanced internalization of pseudovirions and virus-like proteins (VLPs) lacking a glycoprotein, providing evidence that TIM-1 and PtdSer-binding receptors can mediate virus uptake independent of a glycoprotein. These results provide evidence for a broad role of TIM-1 as a PtdSer-binding receptor that mediates enveloped-virus uptake. Utilization of PtdSer-binding receptors may explain the wide tropism of many of these viruses and provide new avenues for controlling their virulence.
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Cited by
Tabata, T., Petitt, M., Puerta-Guardo, H., Michlmayr, D., Wang, C., Fang-Hoover, J., Harris, E., & Pereira, L. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.07.002 · Cited by 486
Wang, Y., Wang, Y., Ding, L., Ren, X., Wang, B., Wang, L., Zhao, S., Yue, X., Wu, Z., Li, C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111738 · Cited by 27
Metadata
- Authors
- Moller-Tank, S., Kondratowicz, A. S., Davey, R. A., Rennert, P. D., & Maury, W.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2013-08
- Volume
- 87
- Issue
- 15
- Pages
- 8327-8341
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2122121966
- Cited by
- 285
- References
- 74
- FWCI
- 14.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Moller-Tank, S., Kondratowicz, A. S., Davey, R. A., Rennert, P. D., & Maury, W. (2013). Role of the Phosphatidylserine Receptor TIM-1 in Enveloped-Virus Entry. Journal of Virology. https://doi.org/10.1128/jvi.01025-13
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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