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Cited by 27

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Tim-4 reprograms cholesterol metabolism to suppress antiviral innate immunity by disturbing the Insig1-SCAP interaction in macrophages

Wang, Yingchun, Wang, Yuzhen, Ding, Lu, Ren, Xiaolei, Wang, Bo, Wang, Liyuan, Zhao, Songbo, Yue, Xuetian, Wu, Zhuanchang, Li, Chunyang, Liang, Xiaohong, Ma, Chunhong, Gao, Lifen·2022·Cell Reports
DOI 10.1016/j.celrep.2022.111738
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  • INSIG1 deficiency or activation of its downstream signaling promotes increased cellular cholesterol levels.

    “These findings are consistent with previous studies demonstrating that INSIG1 deficiency or activation of its downstream signaling promotes increased cellular cholesterol levels55,56.”

    From Macrophage INSIG1 deficiency drives psoriasiform dermatitis via the SREBP2-STAT1 axis (2026) · cites this paper as [56]

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Metadata

Authors
Wang, Y., Wang, Y., Ding, L., Ren, X., Wang, B., Wang, L., Zhao, S., Yue, X., Wu, Z., Li, C., Liang, X., Ma, C., & Gao, L.
ORCID
Gao, Lifen
Venue
Cell Reports
Publisher
Elsevier BV
Published
2022-11
Volume
41
Issue
9
Pages
111738
ISSN
2211-1247
DOI
10.1016/j.celrep.2022.111738
Cited by
27
References
4
Language
en
Licence
Funders
  • National Key Research and Development Program of China
  • Shandong University (2020QNQT001)
  • National Natural Science Foundation of China (2021YFC2300603, 81970508, 81971480)
  • Natural Science Foundation of Shandong Province (ZR2019LZL013, ZR2020ZD12)

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