Dendritic Cell-Mediated trans -Enhancement of Human Immunodeficiency Virus Type 1 Infectivity Is Independent of DC-SIGN
Open accessAbstract
Dendritic cells (DCs) enhance human immunodeficiency virus type 1 (HIV-1) infection of CD4(+) T lymphocytes in trans. The C-type lectin DC-SIGN, expressed on DCs, binds to the HIV-1 envelope glycoprotein gp120 and confers upon some cell lines the capacity to enhance trans-infection. Using a short hairpin RNA approach, we demonstrate that DC-SIGN is not required for efficient trans-enhancement by DCs. In addition, the DC-SIGN ligand mannan and an anti-DC-SIGN antibody did not inhibit DC-mediated enhancement. HIV-1 particles were internalized and were protected from protease treatment following binding to DCs, but not from binding to DC-SIGN-expressing Raji cells. Thus, DC-SIGN is not required for DC-mediated trans-enhancement of HIV infectivity.
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There exists a DC-SIGN-independent mechanism of trans-infection with HIV-1 viral particles.
“However, the results of other studies indicate the existence of a DC-SIGN-independent mechanism of trans-infection with HIV-1 viral particles [81,82,83,84].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [82]
Cites
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Phogat, S. K., Wyatt, R. T., & Hedestam, G. B. K. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01820.x · Cited by 51 · see citing works
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InfluentialSelf-citationInnate immune responses in primary HIV-1 infection
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Immune Responses to Retroviruses
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“Although DC-SIGN was reported to bind HIV-1 in immature DCs (116, 117), inhibition of DC-SIGN expression did not affect trans-infection (123).”
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“. However, the role of DC-SIGN in DC trans-infection of T cells has recently been questioned”
BackgroundThe multiple facets of HIV attachment to dendritic cell lectins
Tsegaye, T., & Pöhlmann, S. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01519.x · Cited by 35 · see citing works
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Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells
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DC-SIGN plays a stronger role than DCIR in mediating HIV-1 capture and transfer.
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ResultCellular Entry of Retroviruses
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“DC-SIGN expression is not required for trans-infection of T cells, as other mannose C-type lectin receptors are involved in HIV binding to DCs and can substitute for DC-SIGN when it is not available (7).”
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Xie, M., Leroy, H., Mascarau, R., Woottum, M., Dupont, M., Ciccone, C., Schmitt, A., Raynaud‐Messina, B., Vérollet, C., Bouchet, J., et al. (2019) · mBio · doi:10.1128/mbio.02457-19 · Cited by 32 · see citing works
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“Furthermore, other studies have suggested that DC-mediated enhancement of HIV-1 and SIV infection may occur by mechanisms independent of DC-SIGN (Boggiano et al., 2007;Gummuluru et al., 2003;Wu et al., 2002b).”
BackgroundRoles of Virion-Incorporated CD162 (PSGL-1), CD43, and CD44 in HIV-1 Infection of T Cells
Murakami, T., & Ono, A. (2021) · Viruses · doi:10.3390/v13101935 · Cited by 11 · see citing works
“DC-SIGN on the surface of B c lls and immature DCs mediates virus capture [79,80,86] throu h bi ding to Env glycans but is dispensable for immature DC-mediated tran -infection [87].”
BackgroundHIV Impairment of Immune Responses in Dendritic Cells
Ahmed, Z., Czubala, M. A., Blanchet, F. P., & Piguet, V. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4433-6_8 · Cited by 8 · see citing works
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Interactions Between HIV-1 and Innate Immunity in Dendritic Cells
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“Dendritic cells have a denser actin cytoskeleton and several surface molecules with higher affinity for the HIV-1 viral envelope than the CD4 receptor that capture HIV in surface-bound compartments, making endocytosis an important restriction mechanism in DCs (16, 57).”
Lectin-like interactions in virus–cell recognition
Steffen, I., Tsegaye, T., & Pöhlmann, S. (2009) · Microbial Glycobiology · doi:10.1016/b978-0-12-374546-0.00028-6 · Cited by 1 · see citing works
“These studies have subsequently been repeated by several groups and a wide spectrum of effects was observed, ranging from DC-SIGN being responsible for the vast majority of dendritic cell-mediated HIV trans-infection to DC-SIGN not being involved in this process at all (Baribaud et al., 2002; Wu et al., 2002a,b; Trump…”
BackgroundInnate Recognition of HIV-1 Glycans: Implications for Infection, Transmission, and Immunity
van der Aar, A. M. G., Gringhuis, S., & Geijtenbeek, T. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8872-9_2 · Cited by 1 · see citing works
“Although, some studies suggest that DC-mediated transmission of HIV-1 by DCs can occur independently of DC-SIGN (Boggiano et al. 2007 ; Gummuluru et al. 2003 ), many studies indicate that DC-mediated trans -infection of CD4 + T cells by HIV-1 is mainly facilitated via DC-SIGN (Arrighi et al. 2004 ;…”
Background
- Authors
- Boggiano, C., Manel, N., & Littman, D. R.
- Affiliations
- Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016
- New York University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Littman, Dan R.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-03
- Volume
- 81
- Issue
- 5
- Pages
- 2519-2523
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC1865951
- OpenAlex
- W2154892007
- Cited by
- 81
- References
- 22
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 4 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 4 · 2013: 9 · 2012: 10
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
- Keywords
- dendritic cells, HIV-1, DC-SIGN, C-type lectin, gp120, CD4+ T cells, mannan, HIV-1 envelope glycoprotein
- MeSH terms
- DC-Specific ICAM-3 Grabbing Nonintegrin, Base Sequence, Dendritic Cells, DNA, Fetal Blood, Humans, Infant, Newborn, Receptors, Cell Surface, Recombinant Proteins, HIV-1, HIV Infections, HIV Envelope Protein gp120, Cell Adhesion Molecules, Gene Expression, Lectins, C-Type, Green Fluorescent Proteins, In Vitro Techniques
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