Functionally Distinct Transmission of Human Immunodeficiency Virus Type 1 Mediated by Immature and Mature Dendritic Cells

Wang, Jian-Hua; Janas, Alicia M.; Olson, Wendy J.; Wu, Li

doi:10.1128/jvi.00878-07

Cited by 125HIV Research and TreatmentImmunotherapy and Immune ResponsesHIV/AIDS Research and Interventions

Functionally Distinct Transmission of Human Immunodeficiency Virus Type 1 Mediated by Immature and Mature Dendritic Cells

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Wang, Jian-Hua, Janas, Alicia M., Olson, Wendy J., Wu, Li·2007·Journal of Virology

DOI 10.1128/jvi.00878-07PMC PMC1951429

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Abstract

Dendritic cells (DCs) potently stimulate the transmission of human immunodeficiency virus type 1 (HIV-1) to CD4(+) T cells. Immature DCs (iDCs) located in submucosal tissues can capture HIV-1 and migrate to lymphoid tissues, where they become mature DCs (mDCs) for effective antigen presentation. DC maturation promotes HIV-1 transmission; however, the underlying mechanisms remain unclear. Here we have compared monocyte-derived iDCs and mDCs for their efficiencies and mechanisms of HIV-1 transmission. We have found that mDCs significantly facilitate HIV-1 endocytosis and efficiently concentrate HIV-1 at virological synapses, which contributes to mDC-enhanced viral transmission, at least in part. mDCs were more efficient than iDCs in transferring HIV-1 to various types of target cells independently of C-type lectins, which partially accounted for iDC-mediated HIV-1 transmission. Efficient HIV-1 trans-infection mediated by iDCs and mDCs required contact between DCs and target cells. Moreover, rapid HIV-1 degradation occurred in both iDCs and mDCs, which correlated with the lack of HIV-1 retention-mediated long-term viral transmission. Our results provide new insights into the mechanisms underlying DC-mediated HIV-1 transmission, suggesting that HIV-1 exploits mDCs to facilitate its dissemination within lymphoid tissues.

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In trans-infection, immature and mature DCs transmit captured HIV-1 to T cells within the first 24 h without being infected themselves.
“In trans-infection, immature and mature DCs transmit captured HIV-1 to T cells within the first 24 h without being infected themselves [66,67,68].”
From HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread (2022) · cites this paper as [68]

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Maturation of Blood-Derived Dendritic Cells Enhances Human Immunodeficiency Virus Type 1 Capture and Transmission
Izquierdo-Useros, N., Blanco, J., Erkizia, I., Fernández-Figueras, M. T., Borràs, F. E., Naranjo-Gómez, M., Bofill, M., Ruiz, L., Clotet, B., & Martinez-Picado, J. (2007) · Journal of Virology · doi:10.1128/jvi.02572-06 · Cited by 108 · see citing works
Dendritic Cells Transmit Human Immunodeficiency Virus Type 1 to Monocytes and Monocyte-Derived Macrophages
Kacani, L., Frank, I., Spruth, M., Schwendinger, M. G., Müllauer, B., Sprinzl, G. M., Steindl, F., & Dierich, M. P. (1998) · Journal of Virology · doi:10.1128/jvi.72.8.6671-6677.1998 · Cited by 39 · see citing works
Differential Transmission of Human Immunodeficiency Virus Type 1 by Distinct Subsets of Effector Dendritic Cells
Sanders, R. W., de Jong, E. C., Baldwin, C. E., Schuitemaker, J. H. N., Kapsenberg, M. L., & Berkhout, B. (2002) · Journal of Virology · doi:10.1128/jvi.76.15.7812-7821.2002 · Cited by 141 · see citing works
Cellular and Viral Mechanisms of HIV-1 Transmission Mediated by Dendritic Cells
Coleman, C. M., Gelais, C. S., & Wu, L. J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4433-6_4 · Cited by 31 · see citing works
Self-citation
Characterization of Human Immunodeficiency Virus Type 1 Replication in Immature and Mature Dendritic Cells Reveals Dissociable cis- and trans-Infection
Dong, C., Janas, A. M., Wang, J.-H., Olson, W., & Wu, L. (2007) · Journal of Virology · doi:10.1128/jvi.01081-07 · Cited by 106 · see citing works
Self-citation

Authors: Wang, J.-H., Janas, A. M., Olson, W. J., & Wu, L.
Affiliations: Medical College of Wisconsin (US)
Corresponding author: Wu, Li
ORCID: Wu, Li
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 2007-09
Volume: 81
Issue: 17
Pages: 8933-8943
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.00878-07
PMC: PMC1951429
OpenAlex: W2170379872
Cited by: 125
References: 58
Citations by year: 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 3 · 2019: 5 · 2017: 3 · 2016: 6 · 2015: 8 · 2014: 11 · 2013: 12 · 2012: 16
FWCI: 4.51
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical College of Wisconsin
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI068493)
Topics: Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Health Sciences › Medicine › Infectious Diseases › HIV/AIDS Research and Interventions
Keywords: HIV-1 transmission, dendritic cells, dendritic cell maturation, immature dendritic cells, monocyte-derived dendritic cells, virological synapse, C-type lectin, trans-infection, viral degradation, CD4+ T cells
MeSH terms: Cells, Cultured, Dendritic Cells, Endocytosis, Humans, HIV-1, Lectins, C-Type, Microscopy, Electron, Transmission, Virus Internalization

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Functionally Distinct Transmission of Human Immunodeficiency Virus Type 1 Mediated by Immature and Mature Dendritic Cells

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