Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice
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While broadly protective antibodies against the influenza A virus hemagglutinin have been well studied, very limited information is available for antibodies that broadly recognize influenza B viruses. Similarly, the development of a universal or broadly protective influenza B virus vaccine lags behind the development of such a vaccine for influenza A virus. More information about epitope location and mechanism of action of broadly protective influenza B virus antibodies is required to inform vaccine development. In addition, protective antibodies could be a useful tool to treat or prevent influenza B virus infection in pediatric cohorts or in a therapeutic setting in immunocompromised individuals in conjugation with existing treatment avenues.
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Non-neutralizing binding antibodies have shown protective effects in many viral infections.
“Binding, non-neutralizing antibodies have also been shown to have a protective effect in many viral infections (Asthagiri Arunkumar et al., 2019; DiLillo et al., 2014; Saphire et al., 2018)”
From SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2 (2021) · cites this paper as Asthagiri Arunkumar et al., 2019
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Cites
Hobson, D., Curry, R. L., Beare, A. S., & Ward-Gardner, A. (1972) · Epidemiology and Infection · doi:10.1017/s0022172400022610 · Cited by 1,003 · see citing works
Properties of mouse and human IgG receptors and their contribution to disease models
Bruhns, P. (2012) · Blood · doi:10.1182/blood-2012-01-380121 · Cited by 869 · see citing works
Highly Conserved Protective Epitopes on Influenza B Viruses
Dreyfus, C., Laursen, N. S., Kwaks, T., Zuijdgeest, D., Khayat, R., Ekiert, D. C., Lee, J. H., Metlagel, Z., Bujny, M. V., Jongeneelen, M. A. C., et al. (2012) · Science · doi:10.1126/science.1222908 · Cited by 867 · see citing works
A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses
Ekiert, D. C., Friesen, R. H. E., Bhabha, G., Kwaks, T., Jongeneelen, M. A. C., Yu, W., Ophorst, C., Cox, F., Korse, H. J. W. M., Brandenburg, B., et al. (2011) · Science · doi:10.1126/science.1204839 · Cited by 823 · see citing works
DiLillo, D. J., Tan, G. S., Palese, P., & Ravetch, J. V. (2014) · Nature Medicine · doi:10.1038/nm.3443 · Cited by 749 · see citing works
Mouse and human FcR effector functions
Bruhns, P., & Jönsson, F. (2015) · Immunological Reviews · doi:10.1111/imr.12350 · Cited by 573 · see citing works
Cocirculation of two distinct evolutionary lineages of influenza type B virus since 1983
Rota, P. A., Wallis, T. R., Harmon, M. W., Rota, J. S., Kendal, A. P., & Nerome, K. (1990) · Virology · doi:10.1016/0042-6822(90)90186-u · Cited by 539 · see citing works
A New Type of Virus from Epidemic Influenza
Francis, T. (1940) · Science · doi:10.1126/science.92.2392.405 · Cited by 274 · see citing works
Henry Dunand, C. J., Leon, P. E., Huang, M., Choi, A., Chromikova, V., Ho, I. Y., Tan, G. S., Cruz, J., Hirsh, A., Zheng, N.-Y., et al. (2016) · Cell Host & Microbe · doi:10.1016/j.chom.2016.05.014 · Cited by 268 · see citing works
Self-citationThe influenza virus hemagglutinin head evolves faster than the stalk domain
Roubidoux, E. K., Qiu, X., Wilson, P. C., Bahl, J., & Krammer, F. (2018) · Scientific Reports · doi:10.1038/s41598-018-28706-1 · Cited by 231 · see citing works
Self-citationYamashita, M., Krystal, M., Fitch, W. M., & Palese, P. (1988) · Virology · doi:10.1016/0042-6822(88)90238-3 · Cited by 223 · see citing works
Marsh, G. A., Hatami, R., & Palese, P. (2007) · Journal of Virology · doi:10.1128/jvi.01144-07 · Cited by 203 · see citing works
Universal influenza virus vaccines and therapeutic antibodies
Nachbagauer, R., & Krammer, F. (2017) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2017.02.009 · Cited by 184 · see citing works
Self-citationHe, W., Tan, G. S., Mullarkey, C. E., Lee, A. J., Lam, M. M. W., Krammer, F., Henry, C., Wilson, P. C., Ashkar, A. A., Palese, P., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1609316113 · Cited by 180 · see citing works
Self-citationKrammer, F., Margine, I., Tan, G. S., Pica, N., Krause, J. C., & Palese, P. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043603 · Cited by 174 · see citing works
Self-citationMargine, I., Palese, P., & Krammer, F. (2013) · Journal of Visualized Experiments · doi:10.3791/51112 · Cited by 169 · see citing works
Self-citationWohlbold, T. J., & Krammer, F. (2014) · Viruses · doi:10.3390/v6062465 · Cited by 168 · see citing works
Self-citationMechanisms of Hemagglutinin Targeted Influenza Virus Neutralization
Brandenburg, B., Koudstaal, W., Goudsmit, J., Klaren, V., Tang, C., Bujny, M. V., Korse, H. J. W. M., Kwaks, T., Otterstrom, J., Juraszek, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080034 · Cited by 166 · see citing works
He, W., Chen, C.-J., Mullarkey, C. E., Hamilton, J. R., Wong, C. K., Leon, P. E., Uccellini, M. B., Chromikova, V., Henry, C., Hoffman, K. W., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00928-3 · Cited by 166 · see citing works
Self-citationBroadly neutralizing antibodies against influenza virus and prospects for universal therapies
Ekiert, D. C., & Wilson, I. A. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.02.005 · Cited by 150 · see citing works
Tan, G. S., Leon, P. E., Albrecht, R. A., Margine, I., Hirsh, A., Bahl, J., & Krammer, F. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005578 · Cited by 147 · see citing works
Self-citationKrammer, F., Schinko, T., Palmberger, D., Tauer, C., Messner, P., & Grabherr, R. M. (2010) · Molecular Biotechnology · doi:10.1007/s12033-010-9268-3 · Cited by 131 · see citing works
Self-citationWohlbold, T. J., Podolsky, K. A., Chromikova, V., Roubidoux, E. K., Falconieri, V., Meade, P. S., Amanat, F., Tan, J., tenOever, B. R., Tan, G. S., et al. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0011-8 · Cited by 130 · see citing works
Self-citationInfluenza B Virus NS1-Truncated Mutants: Live-Attenuated Vaccine Approach
Hai, R., Martínez‐Sobrido, L., Fraser, K. A., et al. (2008) · Journal of Virology · doi:10.1128/jvi.01213-08 · Cited by 126 · see citing works
Tan, G. S., Lee, P. S., Hoffman, R. M. B., Mazel‐Sanchez, B., Krammer, F., Leon, P. E., Ward, A. B., Wilson, I. A., & Palese, P. (2014) · Journal of Virology · doi:10.1128/jvi.02289-14 · Cited by 119 · see citing works
Self-citationLeon, P. E., He, W., Mullarkey, C. E., Bailey, M. J., Miller, M. S., Krammer, F., Palese, P., & Tan, G. S. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1613225113 · Cited by 118 · see citing works
Self-citationInfluenza B Viruses: Not to be Discounted
van de Sandt, C. E., Bodewes, R., Rimmelzwaan, G. F., & de Vries, R. D. (2015) · Future Microbiology · doi:10.2217/fmb.15.65 · Cited by 104 · see citing works
Structural insights into the design of novel anti-influenza therapies
Wu, N. C., & Wilson, I. A. (2018) · Nature Structural & Molecular Biology · doi:10.1038/s41594-018-0025-9 · Cited by 96 · see citing works
Shen, C., Chen, J., Li, R., Zhang, M., Wang, G., Stegalkina, S. S., Zhang, L., Chen, J., Cao, J., Bi, X., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aam5752 · Cited by 93 · see citing works
Ermler, M. E., Roubidoux, E. K., Sun, W., Hai, R., Amanat, F., Chromikova, V., Palese, P., & Krammer, F. (2017) · Journal of Virology · doi:10.1128/jvi.00286-17 · Cited by 90 · see citing works
Self-citationWohlbold, T. J., Chromikova, V., Tan, G. S., Meade, P. S., Amanat, F., Comella, P., Hirsh, A., & Krammer, F. (2015) · Journal of Virology · doi:10.1128/jvi.02275-15 · Cited by 81 · see citing works
Self-citationStructural basis for the divergent evolution of influenza B virus hemagglutinin
Ni, F., Kondrashkina, E., & Wang, Q. (2013) · Virology · doi:10.1016/j.virol.2013.07.035 · Cited by 67 · see citing works
A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action
Chai, N., Swem, L. R., Park, S., et al. (2017) · Nature Communications · doi:10.1038/ncomms14234 · Cited by 67 · see citing works
Cox, F., Kwaks, T., Brandenburg, B., Koldijk, M. H., Klaren, V., Smal, B., Korse, H. J. W. M., Geelen, E., Tettero, L., Zuijdgeest, D., et al. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00399 · Cited by 57 · see citing works
Divergent H7 Immunogens Offer Protection from H7N9 Virus Challenge
Krammer, F., Albrecht, R. A., Tan, G. S., Margine, I., Hai, R., Schmolke, M., Runstadler, J. A., Andrews, S. F., Wilson, P. C., Cox, R. J., et al. (2014) · Journal of Virology · doi:10.1128/jvi.03095-13 · Cited by 54 · see citing works
Self-citationMargine, I., Palese, P., & Krammer, F. (2013) · Journal of Visualized Experiments · doi:10.3791/51112-v · Cited by 54 · see citing works
Self-citationInfluenza-associated pediatric deaths--United States, September 2010-August 2011.
(2011) · PubMed · Cited by 51 · see citing works
Universal influenza virus vaccines and therapeutics: where do we stand with influenza B virus?
Tan, J., Arunkumar, G. A., & Krammer, F. (2018) · Current Opinion in Immunology · doi:10.1016/j.coi.2018.04.002 · Cited by 43 · see citing works
Self-citationThe Role of Fc Gamma Receptors in Broad Protection against Influenza Viruses
Thulin, N. K., & Wang, T. T. (2018) · Vaccines · doi:10.3390/vaccines6030036 · Cited by 37 · see citing works
Rajendran, M., Sun, W., Comella, P., Nachbagauer, R., Wohlbold, T. J., Amanat, F., Roubidoux, E. K., Palese, P., & Krammer, F. (2018) · PLoS ONE · doi:10.1371/journal.pone.0194830 · Cited by 31 · see citing works
Self-citationThe Potential Role of Fc-Receptor Functions in the Development of a Universal Influenza Vaccine
Jegaskanda, S. (2018) · Vaccines · doi:10.3390/vaccines6020027 · Cited by 24 · see citing works
Native Human Monoclonal Antibodies with Potent Cross-Lineage Neutralization of Influenza B Viruses
Vigil, A., Estellés, A., Kauvar, L. M., Johnson, S. K., Tripp, R. A., & Wittekind, M. G. (2018) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.02269-17 · Cited by 19 · see citing works
White, K. M., Ayllón, J., Mena, I., et al. (2018) · Vaccine · doi:10.1016/j.vaccine.2018.01.050 · Cited by 10 · see citing works
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SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2
Amanat, F., Thapa, M., Lei, T., Ahmed, S. M. S., Adelsberg, D. C., Carreño, J. M., Strohmeier, S., Schmitz, A. J., Zafar, S., Zhou, J. Q., et al. (2021) · Cell · doi:10.1016/j.cell.2021.06.005 · Cited by 273 · see citing works
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- Authors
- Asthagiri Arunkumar, G., Ioannou, A., Wohlbold, T. J., Meade, P., Aslam, S., Amanat, F., Ayllon, J., García-Sastre, A., & Krammer, F.
- Affiliations
- Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
- Icahn School of Medicine at Mount Sinai (US)
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2019-03-15
- Volume
- 93
- Issue
- 6
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC6401450
- OpenAlex
- W2909919629
- Cited by
- 80
- References
- 43
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 6 · 2023: 14 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 10
- FWCI
- 9.90
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Repositorio Institucional de la Universidad de Burgos (University of Burgos) (submittedVersion, cc-by)
- Funders
- HHS | NIH | National Institute of Allergy and Infectious Diseases (AI097092, HHSN272201400008C, AI109946, 5T32AI007647, AI117287)
- Topics
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- influenza B, hemagglutinin, non-neutralizing antibodies, antibody effector functions, protective immunity, universal influenza vaccine, epitope mapping, therapeutic antibodies, immunocompromised patients
- MeSH terms
- Animals, Antibodies, Viral, Antibody-Dependent Cell Cytotoxicity, Epitopes, Cell Line, Cross Reactions, Dogs, Female, Humans, Influenza Vaccines, Mice, Inbred BALB C, Orthomyxoviridae Infections, Influenza B virus, Hemagglutinin Glycoproteins, Influenza Virus, Cell Line, Tumor, Mice, Antibodies, Neutralizing, Madin Darby Canine Kidney Cells, Sf9 Cells
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