Cited by 80Influenza Virus Research StudiesMonoclonal and Polyclonal Antibodies Researchvaccines and immunoinformatics approaches

Broadly Cross-Reactive, Nonneutralizing Antibodies against Influenza B Virus Hemagglutinin Demonstrate Effector Function-Dependent Protection against Lethal Viral Challenge in Mice

Open access
Asthagiri Arunkumar, Guha, Ioannou, Andriani, Wohlbold, Teddy John, Meade, Philip, Aslam, Sadaf, Amanat, Fatima, Ayllon, Juan, García-Sastre, Adolfo +1 more·2019·Journal of Virology

Abstract

While broadly protective antibodies against the influenza A virus hemagglutinin have been well studied, very limited information is available for antibodies that broadly recognize influenza B viruses. Similarly, the development of a universal or broadly protective influenza B virus vaccine lags behind the development of such a vaccine for influenza A virus. More information about epitope location and mechanism of action of broadly protective influenza B virus antibodies is required to inform vaccine development. In addition, protective antibodies could be a useful tool to treat or prevent influenza B virus infection in pediatric cohorts or in a therapeutic setting in immunocompromised individuals in conjugation with existing treatment avenues.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1128/jvi.01696-18

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Non-neutralizing binding antibodies have shown protective effects in many viral infections.

    “Binding, non-neutralizing antibodies have also been shown to have a protective effect in many viral infections (Asthagiri Arunkumar et al., 2019; DiLillo et al., 2014; Saphire et al., 2018)”

    From SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2 (2021) · cites this paper as Asthagiri Arunkumar et al., 2019

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Asthagiri Arunkumar, G., Ioannou, A., Wohlbold, T. J., Meade, P., Aslam, S., Amanat, F., Ayllon, J., García-Sastre, A., & Krammer, F.
Affiliations
  • Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA
  • Icahn School of Medicine at Mount Sinai (US)
Venue
Journal of Virology
Published
2019-03-15
Volume
93
Issue
6
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2909919629
Cited by
80
References
43
Citations by year
2026: 4 · 2025: 4 · 2024: 6 · 2023: 14 · 2022: 10 · 2021: 18 · 2020: 14 · 2019: 10
FWCI
9.90
Type
journal article
Language
en
Open access
Locations
  • Journal of Virology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Repositorio Institucional de la Universidad de Burgos (University of Burgos) (submittedVersion, cc-by)
Funders
HHS | NIH | National Institute of Allergy and Infectious Diseases (AI097092, HHSN272201400008C, AI109946, 5T32AI007647, AI117287)
Topics
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Monoclonal and Polyclonal Antibodies Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
Keywords
influenza B, hemagglutinin, non-neutralizing antibodies, antibody effector functions, protective immunity, universal influenza vaccine, epitope mapping, therapeutic antibodies, immunocompromised patients
MeSH terms
Animals, Antibodies, Viral, Antibody-Dependent Cell Cytotoxicity, Epitopes, Cell Line, Cross Reactions, Dogs, Female, Humans, Influenza Vaccines, Mice, Inbred BALB C, Orthomyxoviridae Infections, Influenza B virus, Hemagglutinin Glycoproteins, Influenza Virus, Cell Line, Tumor, Mice, Antibodies, Neutralizing, Madin Darby Canine Kidney Cells, Sf9 Cells

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review