The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
MicroRNA Expression and Virulence in Pandemic Influenza Virus-Infected Mice
Open accessAbstract
The worst known H1N1 influenza pandemic in history resulted in more than 20 million deaths in 1918 and 1919. Although the underlying mechanism causing the extreme virulence of the 1918 influenza virus is still obscure, our previous functional genomics analyses revealed a correlation between the lethality of the reconstructed 1918 influenza virus (r1918) in mice and a unique gene expression pattern associated with severe immune responses in the lungs. Lately, microRNAs have emerged as a class of crucial regulators for gene expression. To determine whether differential expression of cellular microRNAs plays a role in the host response to r1918 infection, we compared the lung cellular “microRNAome” of mice infected by r1918 virus with that of mice infected by a nonlethal seasonal influenza virus, A/Texas/36/91. We found that a group of microRNAs, including miR-200a and miR-223, were differentially expressed in response to influenza virus infection and that r1918 and A/Texas/36/91 infection induced distinct microRNA expression profiles. Moreover, we observed significant enrichment in the number of predicted cellular target mRNAs whose expression was inversely correlated with the expression of these microRNAs. Intriguingly, gene ontology analysis revealed that many of these mRNAs play roles in immune response and cell death pathways, which are known to be associated with the extreme virulence of r1918. This is the first demonstration that cellular gene expression patterns in influenza virus-infected mice may be attributed in part to microRNA regulation and that such regulation may be a contributing factor to the extreme virulence of the r1918.
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Cites
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
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Characterization of the reconstructed 1918 Spanish influenza pandemic virus
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Self-citationA novel and universal method for microRNA RT-qPCR data normalization
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Self-citationOrigin and evolution of the 1918 “Spanish” influenza virus hemagglutinin gene
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Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus
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Cited by
MicroRNAs in Common Human Diseases
Li, Y., & Kowdley, K. V. (2012) · Genomics, Proteomics & Bioinformatics · doi:10.1016/j.gpb.2012.07.005 · Cited by 360
Self-citationMenachery, V. D., Eisfeld, A. J., Schäfer, A., Josset, L., Sims, A. C., Proll, S., Fan, S., Li, C., Neumann, G., Tilton, S. C., et al. (2014) · mBio · doi:10.1128/mbio.01174-14 · Cited by 305
Self-citationCellular MicroRNAs Inhibit Replication of the H1N1 Influenza A Virus in Infected Cells
Song, L., Liu, H., Gao, S., Jiang, W., & Huang, W. (2010) · Journal of Virology · doi:10.1128/jvi.00456-10 · Cited by 294
HIV-1 tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation.
Chivero, E. T., Guo, M.-L., Periyasamy, P., Liao, K., Callen, S. E., & Buch, S. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3045-16.2017 · Cited by 201
Cilloniz, C., Pantin-Jackwood, M. J., Ni, C., Goodman, A. G., Peng, X., Proll, S. C., Carter, V. S., Rosenzweig, E. R., Szretter, K. J., Katz, J. M., et al. (2010) · Journal of Virology · doi:10.1128/jvi.00553-10 · Cited by 136
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Metadata
- Authors
- Li, Y., Chan, E. Y., Li, J., Ni, C., Peng, X., Rosenzweig, E., Tumpey, T. M., & Katze, M. G.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2010-03-15
- Volume
- 84
- Issue
- 6
- Pages
- 3023-3032
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2117760019
- Cited by
- 164
- References
- 7
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- green
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