The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Subdominant CD8+T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication
Open accessAbstract
“Elite controllers” are individuals that durably control human immunodeficiency virus or simian immunodeficiency virus replication without therapeutic intervention. The study of these rare individuals may facilitate the definition of a successful immune response to immunodeficiency viruses. Here we describe six Indian-origin rhesus macaques that have controlled replication of the pathogenic virus SIVmac239 for 1 to 5 years. To determine which lymphocyte populations were responsible for this control, we transiently depleted the animals’ CD8+cells in vivo. This treatment resulted in 100- to 10,000-fold increases in viremia. When the CD8+cells returned, control was reestablished and the levels of small subsets of previously subdominant CD8+T cells expanded up to 2,500-fold above predepletion levels. This wave of CD8+T cells was accompanied by robust Gag-specific CD4 responses. In contrast, CD8+NK cell frequencies changed no more than threefold. Together, our data suggest that CD8+T cells targeting a small number of epitopes, along with broad CD4+T-cell responses, can successfully control the replication of the AIDS virus. It is likely that subdominant CD8+T-cell populations play a key role in maintaining this control.
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Reynolds, M. R., Rakasz, E., Skinner, P. J., White, C., Abel, K., Ma, Z.-M., Compton, L., Napoé, G., Wilson, N., Miller, C. J., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.14.9228-9235.2005 · Cited by 168
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Cited by
Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
Hansen, S. G., Ford, J. C., Lewis, M. S., Ventura, A. B., Hughes, C. M., Coyne-Johnson, L., Whizin, N., Oswald, K., Shoemaker, R., Swanson, T., et al. (2011) · Nature · doi:10.1038/nature10003 · Cited by 988
Deeks, S. G., & Walker, B. D. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.010 · Cited by 759
Hansen, S. G., Vieville, C., Whizin, N., Coyne-Johnson, L., Siess, D. C., Drummond, D. D., Legasse, A. W., Axthelm, M. K., Oswald, K., Trubey, C. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1935 · Cited by 675
Fukazawa, Y., Lum, R., Okoye, A. A., Park, H., Matsuda, K., Bae, J. Y., Hagen, S. I., Shoemaker, R., Deleage, C., Lucero, C., et al. (2015) · Nature Medicine · doi:10.1038/nm.3781 · Cited by 477
CD8+ T cell efficacy in vaccination and disease
Appay, V., Douek, D. C., & Price, D. A. (2008) · Nature Medicine · doi:10.1038/nm.f.1774 · Cited by 393
Metadata
- Authors
- Friedrich, T. C., Valentine, L. E., Yant, L. J., Rakasz, E. G., Piaskowski, S. M., Furlott, J. R., Weisgrau, K. L., Burwitz, B., May, G. E., León, E. J., Soma, T., Napoe, G., Capuano, S. V., Wilson, N. A., & Watkins, D. I.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2007-04
- Volume
- 81
- Issue
- 7
- Pages
- 3465-3476
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2162774944
- Cited by
- 220
- References
- 1
- FWCI
- 9.48
- Type
- journal article
- Language
- en
- Open access
- green
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- Friedrich, T. C., Valentine, L. E., Yant, L. J., Rakasz, E. G., Piaskowski, S. M., Furlott, J. R., Weisgrau, K. L., Burwitz, B., May, G. E., León, E. J., Soma, T., Napoe, G., Capuano, S. V., Wilson, N. A., & Watkins, D. I. (2007). Subdominant CD8+T-Cell Responses Are Involved in Durable Control of AIDS Virus Replication. Journal of Virology. https://doi.org/10.1128/jvi.02392-06
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
