The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells
Abstract
Recent human infections caused by the highly pathogenic avian influenza virus H5N1 strains emphasize an urgent need for assessment of factors that allow viral transmission, replication, and intra-airway spread. Important determinants for virus infection are epithelial cell receptors identified as glycans terminated by an α2,3-linked sialic acid (SA) that preferentially bind avian strains and glycans terminated by an α2,6-linked SA that bind human strains. The mouse is often used as a model for study of influenza viruses, including recent avian strains; however, the selectivity for infection of specific respiratory cell populations is not well described, and any relationship between receptors in the mouse and human lungs is incompletely understood. Here, using in vitro human and mouse airway epithelial cell models and in vivo mouse infection, we found that the α2,3-linked SA receptor was expressed in ciliated airway and type II alveolar epithelial cells and was targeted for cell-specific infection in both species. The α2,6-linked SA receptor was not expressed in the mouse, a factor that may contribute to the inability of some human strains to efficiently infect the mouse lung. In human airway epithelial cells, α2,6-linked SA was expressed and functional in both ciliated and goblet cells, providing expanded cellular tropism. Differences in receptor and cell-specific expression in these species suggest that differentiated human airway epithelial cell cultures may be superior for evaluation of some human strains, while the mouse can provide a model for studying avian strains that preferentially bind only the α2,3-linked SA receptor.
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Cites
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Cited by
Chua, R. L., Lukassen, S., Trump, S., Hennig, B. P., Wendisch, D., Pott, F., Debnath, O., Thürmann, L., Kurth, F., Völker, M. T., et al. (2020) · Nature Biotechnology · doi:10.1038/s41587-020-0602-4 · Cited by 1,035
Recapitulation of IVIG anti-inflammatory activity with a recombinant IgG Fc
Anthony, R. M., Nimmerjahn, F., Ashline, D. J., Reinhold, V. N., Paulson, J. C., & Ravetch, J. V. (2008) · Science · doi:10.1126/science.1154315 · Cited by 849
Role of receptor binding specificity in influenza A virus transmission and pathogenesis
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Regulation of the alveolar regenerative niche by amphiregulin-producing regulatory T cells
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Guo, Z., Banas, V. S., He, Y., Weiland, E., Xu, J., Tan, Y., Xiao, Z., Brody, S. L., Boon, A. C. M., Janetka, J. W., et al. (2025) · Journal of Virology · doi:10.1128/jvi.00685-25 · Cited by 9
Self-citation
Metadata
- Authors
- Ibricevic, A., Pekosz, A., Walter, M. J., Newby, C., Battaile, J. T., Brown, E. G., Holtzman, M. J., & Brody, S. L.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 2006-08
- Volume
- 80
- Issue
- 15
- Pages
- 7469-7480
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2142943804
- Cited by
- 391
- References
- 55
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ibricevic, A., Pekosz, A., Walter, M. J., Newby, C., Battaile, J. T., Brown, E. G., Holtzman, M. J., & Brody, S. L. (2006). Influenza Virus Receptor Specificity and Cell Tropism in Mouse and Human Airway Epithelial Cells. Journal of Virology. https://doi.org/10.1128/jvi.02677-05
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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