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Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
Open accessAbstract
Genetic and biologic observations suggest that pigs may serve as “mixing vessels” for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics. Here we demonstrate a structural basis for this hypothesis. Cell surface receptors for both human and avian influenza viruses were identified in the pig trachea, providing a milieu conducive to viral replication and genetic reassortment. Surprisingly, with continued replication, some avian-like swine viruses acquired the ability to recognize human virus receptors, raising the possibility of their direct transmission to human populations. These findings help to explain the emergence of pandemic influenza viruses and support the need for continued surveillance of swine for viruses carrying avian virus genes.
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Citations
Cited by
Role of hemagglutinin cleavage for the pathogenicity of influenza virus.
Steinhauer, D. A. (1999) · Virology · doi:10.1006/viro.1999.9716 · Cited by 663
Stevens, J., Blixt, O., Glaser, L., Taubenberger, J. K., Palese, P., Paulson, J. C., & Wilson, I. A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.11.002 · Cited by 613
Self-citationCases of Swine Influenza in Humans: A Review of the Literature
Myers, K. P., Olsen, C. W., & Gray, G. C. (2007) · Clinical Infectious Diseases · doi:10.1086/512813 · Cited by 486
The role of receptor binding specificity in interspecies transmission of influenza viruses
Imai, M., & Kawaoka, Y. (2012) · Current Opinion in Virology · doi:10.1016/j.coviro.2012.03.003 · Cited by 312
Self-citationInfluenza virus neuraminidase contributes to secondary bacterial pneumonia.
Peltola, V. T., Murti, K. G., & McCullers, J. A. (2005) · The Journal of Infectious Diseases · doi:10.1086/430954 · Cited by 219
Metadata
- Authors
- Ito, T., Couceiro, J. N. S. S., Kelm, S., Baum, L. G., Krauss, S., Castrucci, M. R., Donatelli, I., Kida, H., Paulson, J. C., Webster, R. G., & Kawaoka, Y.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1998-09
- Volume
- 72
- Issue
- 9
- Pages
- 7367-7373
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2171369029
- Cited by
- 1,028
- References
- 0
- FWCI
- 16.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Ito, T., Couceiro, J. N. S. S., Kelm, S., Baum, L. G., Krauss, S., Castrucci, M. R., Donatelli, I., Kida, H., Paulson, J. C., Webster, R. G., & Kawaoka, Y. (1998). Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential. Journal of Virology. https://doi.org/10.1128/jvi.72.9.7367-7373.1998
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
