Papillomaviruses in the causation of human cancers - a brief historical account

zur Hausen, Harald

doi:10.1016/j.virol.2008.11.046

Cited by 1,532Cervical Cancer and HPV ResearchViral-associated cancers and disordersHead and Neck Cancer Studies

Papillomaviruses in the causation of human cancers - a brief historical account

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zur Hausen, Harald·2009·Virology

DOI 10.1016/j.virol.2008.11.046

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Abstract

Approximately 35 years ago a role of human papillomaviruses (HPV) in cervical cancer has been postulated. Today it is well established that this very heterogeneous virus family harbours important human carcinogens, causing not only the vast majority of cervical, but also a substantial proportion of other anogenital and head and neck cancers. In addition, specific types have been linked to certain cutaneous cancers. In females, HPV infections on a global scale account for more than 50% of infection-linked cancers, in males for barely 5%. Vaccines against the high risk HPV types 16 and 18 represent the first preventive vaccines directly developed to protect against a major human cancer (cervical carcinoma). This review will cover some of the historical aspects of papillomavirus research; it tries briefly to analyze the present state of linking HPV to human cancers and will discuss some emerging developments.

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High-risk human papillomaviruses are the causative agents of cervical cancer.
“H igh-risk human papillomaviruses (HPV) are the causative agents of cervical cancer (1,2).”
From Comparison of Seegene Anyplex II HPV28 with the PGMY-CHUV Assay for Human Papillomavirus Genotyping (2014) · cites this paper as [2]
Approximately 20% of all HNSCC cases are associated with HPV16 infection.
“Approximately 20% of all HNSCC cases are also now known to be associated with HPV16 infection (zur Hausen, 2009).”
From mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis (2012) · cites this paper as zur Hausen, 2009

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Authors: zur Hausen, H.
Venue: Virology
Publisher: Elsevier BV
Published: 2009-02
Volume: 384
Issue: 2
Pages: 260-265
ISSN: 0042-6822 (ISSN-L)
DOI: 10.1016/j.virol.2008.11.046
OpenAlex: W1966676297
Cited by: 1,532
References: 128
Citations by year: 2026: 38 · 2025: 63 · 2024: 76 · 2023: 86 · 2022: 78 · 2021: 100 · 2020: 79 · 2019: 90 · 2018: 86 · 2017: 84 · 2016: 119 · 2015: 114 · 2014: 103 · 2013: 88 · 2012: 97
FWCI: 13.21
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1658 d)
Locations: Virology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Epidemiology › Cervical Cancer and HPV Research
Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
Keywords: human papillomavirus, cervical cancer, anogenital cancer, head and neck cancer, HPV 16/18, HPV vaccine
MeSH terms: Cell Transformation, Neoplastic, Uterine Cervical Neoplasms, Female, Genital Neoplasms, Female, Genital Neoplasms, Male, Head and Neck Neoplasms, Humans, Male, Skin Neoplasms, Papillomaviridae, Biomedical Research, History, 19th Century, History, 20th Century

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Papillomaviruses in the causation of human cancers - a brief historical account

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