The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus
Open accessAbstract
Cotton rats previously inoculated with Formalin-inactivated respiratory syncytial virus (RSV) were challenged intranasally with live RSV to induce an enhancement of RSV disease similar to that observed after the administration of Formalin-inactivated RSV vaccine to human infants 20 years ago. Within 24 h after infection with RSV, cotton rats developed pulmonary lesions that reached a maximum by day 4. Histologically, the lesions resembled an experimental pulmonary Arthus reaction. An action of Formalin on RSV appears to be responsible for this effect, because live virus or virus heated in the absence of Formalin did not induce enhanced immunopathology. Selected epitopes on the fusion (F) or attachment (G) or both RSV surface glycoproteins that are involved in inducing neutralizing antibodies were modified to reduce or ablate their antigenicity. However, other epitopes on the F or G or both glycoproteins were not ablated by Formalin, because cotton rats inoculated parenterally with a Formalin-inactivated virus developed a high level of F and G antibodies measurable by an enzyme-linked immunosorbent assay. At this time, the effect of Formalin on RSV cannot be localized to either the F or G glycoprotein of RSV.
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KIM, H. W., CANCHOLA, J. G., BRANDT, C. D., PYLES, G., CHANOCK, R. M., JENSEN, K., & PARROTT, R. H. (1969) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a120955 · Cited by 1,981
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Cited by
Groothuis, J. R., Simoes, E., Levin, M. J., Hall, C. B., Long, C. E., Rodriguez, W. J., Arrobio, J., Meissner, H. C., Fulton, D. R., Welliver, R. C., et al. (1993) · New England Journal of Medicine · doi:10.1056/nejm199311183292102 · Cited by 744
Self-citationCannon, M. J., Openshaw, P. J., & Askonas, B. A. (1988) · The Journal of experimental medicine · doi:10.1084/jem.168.3.1163 · Cited by 459
Connors, M., Kulkarni, A. B., Firestone, C. Y., Holmes, K. L., Morse, H. C., Sotnikov, A. V., & Murphy, B. R. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7444-7451.1992 · Cited by 271
Self-citationProspects for a safe COVID-19 vaccine
Haynes, B. F., Corey, L., Fernandes, P., Gilbert, P. B., Hotez, P. J., Rao, S., Santos, M. R., Schuitemaker, H., Watson, M., & Arvin, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abe0948 · Cited by 261
Metadata
- Authors
- Prince, G. A., Jenson, A. B., Hemming, V. G., Murphy, B. R., Walsh, E. E., Horswood, R. L., & Chanock, R. M.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1986-03
- Volume
- 57
- Issue
- 3
- Pages
- 721-728
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1658519144
- Cited by
- 309
- References
- 1
- FWCI
- 11.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus. https://app.cochat.ai/papers/10.1128/jvi.57.3.721-728.1986
- The paper
- Prince, G. A., Jenson, A. B., Hemming, V. G., Murphy, B. R., Walsh, E. E., Horswood, R. L., & Chanock, R. M. (1986). Enhancement of respiratory syncytial virus pulmonary pathology in cotton rats by prior intramuscular inoculation of formalin-inactiva ted virus. Journal of Virology. https://doi.org/10.1128/jvi.57.3.721-728.1986
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