The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus.
Open accessAbstract
We have examined the function of class I MHC-restricted cytotoxic T cells in experimental respiratory syncytial virus (RSV) infection of BALB/c mice by transfer of T cell line MJC-A2 and CTL clone E8a into RSV-infected mice. The T cell line cleared pulmonary RSV infection within 5 d in persistently infected gamma-irradiated mice, but caused acute respiratory disease. This was only seen in infected mice and was often lethal after transfer of greater than 3 x 10(6) CTL. Lower numbers of CTL produced less severe disease but still cleared lung RSV, albeit over a longer time course (up to 10 d). Clearance of lung RSV in immunocompetent mice by the T cell line and CTL clone was again accompanied by acute and sometimes lethal respiratory disease. Bronchoalveolar lavage showed severe lung hemorrhage and frequent neutrophil efflux in mice with CTL-augmented disease.
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Cites
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Prince, G. A., Jenson, A. B., Hemming, V. G., Murphy, B. R., Walsh, E. E., Horswood, R. L., & Chanock, R. M. (1986) · Journal of Virology · doi:10.1128/jvi.57.3.721-728.1986 · Cited by 309
Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo.
Taylor, P. M., & Askonas, B. A. (1986) · PubMed · Cited by 259
Self-citationMonoclonal antibodies protect against respiratory syncytial virus infection in mice.
Taylor, G., Stott, E. J., Bew, M., et al. (1984) · PubMed · Cited by 242
Stott, E. J., & Taylor, G. (1985) · Archives of Virology · doi:10.1007/bf01310552 · Cited by 232
Stott, E. J., Taylor, G., Ball, L. A., Anderson, K., Young, K. K., King, A. M., & Wertz, G. W. (1987) · Journal of Virology · doi:10.1128/jvi.61.12.3855-3861.1987 · Cited by 215
Cannon, M. J., Stott, E. J., Taylor, G., & Askonas, B. A. (1987) · PubMed · Cited by 162
Self-citationRespiratory syncytial virus infection in mice
Taylor, G., Stott, E. J., Hughes, M., & Collins, A. P. (1984) · Infection and Immunity · doi:10.1128/iai.43.2.649-655.1984 · Cited by 157
Prince, G. A., Hemming, V. G., Horswood, R. L., Baron, P. A., & Chanock, R. M. (1987) · Journal of Virology · doi:10.1128/jvi.61.6.1851-1854.1987 · Cited by 146
Recovery from a viral respiratory infection. I. Influenza pneumonia in normal and T-deficient mice.
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Connors, M., Kulkarni, A. B., Firestone, C. Y., Holmes, K. L., Morse, H. C., Sotnikov, A. V., & Murphy, B. R. (1992) · Journal of Virology · doi:10.1128/jvi.66.12.7444-7451.1992 · Cited by 271
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Metadata
- Authors
- Cannon, M. J., Openshaw, P. J., & Askonas, B. A.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1988-09-01
- Volume
- 168
- Issue
- 3
- Pages
- 1163-1168
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2171293480
- Cited by
- 459
- References
- 17
- FWCI
- 10.09
- Type
- journal article
- Language
- en
- Open access
- green
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- Cannon, M. J., Openshaw, P. J., & Askonas, B. A. (1988). Cytotoxic T cells clear virus but augment lung pathology in mice infected with respiratory syncytial virus. The Journal of experimental medicine. https://doi.org/10.1084/jem.168.3.1163
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
