The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope
Open accessAbstract
A monoclonal antibody was produced to the exterior envelope glycoprotein (gp120) of the human T-cell lymphotropic virus (HTLV)-IIIB isolate of the human immunodeficiency virus (HIV). This antibody binds to gp120 of HTLV-IIIB and lymphadenopathy-associated virus type 1 (LAV-1) and to the surface of HTLV-IIIB- and LAV-1-infected cells, neutralizes infection by cell-free virus, and prevents fusion of virus-infected cells. In contrast, it does not bind, or weakly binds, the envelope of four heterologous HIV isolates and does not neutralize heterologous isolates HTLV-IIIRF and HTLV-IIIMN. The antibody-binding site was mapped to a 24-amino-acid segment, using recombinant and synthetic segments of HTLV-IIIB gp120. This site is within a segment of amino acid variability known to contain the major neutralizing epitopes (S. D. Putney, T. J. Matthews, W. G. Robey, D. L. Lynn, M. Robert-Guroff, W. T. Mueller, A. J. Langlois, J. Ghrayeb, S. R. Petteway, K. J. Weinhold, P. J. Fischinger, F. Wong-Staal, R. C. Gallo, and D. P. Bolognesi, Science 234:1392-1395, 1986). These results localize an epitope of HIV type-specific neutralization and suggest that neutralizing antibodies may be effective in controlling cell-associated, as well as cell-free, virus infection.
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Cites
Starcich, B. R., Hahn, B. H., Shaw, G. M., McNeely, P. D., Modrow, S., Wolf, H., Parks, E. S., Parks, W. P., Josephs, S. F., Gallo, R. C., et al. (1986) · Cell · doi:10.1016/0092-8674(86)90778-6 · Cited by 767
Cited by
Showing your ID: intrinsic disorder as an ID for recognition, regulation and cell signaling
Uversky, V. N., Oldfield, C. J., & Dunker, A. K. (2005) · Journal of Molecular Recognition · doi:10.1002/jmr.747 · Cited by 847
Thali, M., Moore, J. P., Furman, C., Charles, M., Ho, D. D., Robinson, J., & Sodroski, J. (1993) · Journal of Virology · doi:10.1128/jvi.67.7.3978-3988.1993 · Cited by 616
Broadly Neutralizing Antibodies Elicited by the Hypervariable Neutralizing Determinant of HIV-1
Javaherian, K., Langlois, A. J., LaRosa, G. J., Profy, A. T., Bolognesi, D. P., Herlihy, W. C., Putney, S. D., & Matthews, T. J. (1990) · Science · doi:10.1126/science.1703322 · Cited by 353
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Metadata
- Authors
- Matsushita, S., Robert-Guroff, M., Rusche, J., Koito, A., Hattori, T., Hoshino, H., Javaherian, K., Takatsuki, K., & Putney, S.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1988-06
- Volume
- 62
- Issue
- 6
- Pages
- 2107-2114
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1568767105
- Cited by
- 376
- References
- 1
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- green
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- Matsushita, S., Robert-Guroff, M., Rusche, J., Koito, A., Hattori, T., Hoshino, H., Javaherian, K., Takatsuki, K., & Putney, S. (1988). Characterization of a human immunodeficiency virus neutralizing monoclonal antibody and mapping of the neutralizing epitope. Journal of Virology. https://doi.org/10.1128/jvi.62.6.2107-2114.1988
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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