The DOI matches its Crossref record.
Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element
Open accessAbstract
The expression of alpha (immediate-early) genes of cytomegalovirus is regulated via a complex enhancer that consists of several different repeat elements. We describe here the autoinduction of expression from the alpha promoter-enhancer by the most abundant alpha gene product, a 491-amino-acid nuclear phosphoprotein referred to as ie1. We defined the 18-base-pair repeat element within the alpha enhancer as the signal through which ie1 acts to regulate gene expression. This element contains an NF kappa B site that may play an important role in ie1 autoregulation. Our analysis, which relied on deletions through the enhancer as well as reconstitution of responsiveness to a promoter with synthetic 18-base-pair repeats, strongly implicated ie1 in the transcriptional transactivation of the alpha promoter through its enhancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Cavanaugh, J. E., Ham, J., Hetman, M., Poser, S., Yan, C., & Xia, Z. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00434.2001 · Cited by 196
ERK1/2 Antagonizes Glycogen Synthase Kinase-3β-induced Apoptosis in Cortical Neurons
Hetman, M., Hsuan, S.-L., Habas, A., Higgins, M. J., & Xia, Z. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111227200 · Cited by 88
Cytomegalovirus Gene Regulation by Reactive Oxygen Species: Agents in Atherosclerosis
SPEIR, E. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06200.x · Cited by 56
Proinflammatory Potential of Cytomegalovirus Infection
Cinatl Jr., J., Vogel, J.-U., Kotchetkov, R., Scholz, M., & Doerr, H. W. (1999) · Intervirology · doi:10.1159/000053980 · Cited by 27
Metadata
- Authors
- Cherrington, J. M., & Mocarski, E. S.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-03
- Volume
- 63
- Issue
- 3
- Pages
- 1435-1440
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1933815796
- Cited by
- 307
- References
- 0
- FWCI
- 17.18
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element. https://app.cochat.ai/papers/10.1128/jvi.63.3.1435-1440.1989
- The paper
- Cherrington, J. M., & Mocarski, E. S. (1989). Human cytomegalovirus ie1 transactivates the alpha promoter-enhancer via an 18-base-pair repeat element. Journal of Virology. https://doi.org/10.1128/jvi.63.3.1435-1440.1989
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
