Cytomegalovirus Gene Regulation by Reactive Oxygen Species: Agents in Atherosclerosis
Abstract
A bstract: Oxidative stress is implicated in the pathogenesis of atherosclerosis, and of viral infections caused by sendai virus, influenza and HIV. Vascular oxidative stress is due to inflammatory and immune responses of vascular cells, and to reperfusion after recanalization of blocked arteries. Because human cytomegalovirus (CMV) may contribute to atherogenesis by several mechanisms, and coronary artery smooth nuscle cells (SMC) are permissive for the virus, we examined CMV interactions with SMC. Infection causes generation of intracellular reactive oxygen species (ROS) which activate NF‐κB, a cellular transcription factor. NF‐κB mediates expression of the CMV promoter and of genes involved in the immune and inflammatory responses. Antioxidants or aspirin inhibit ROS, NF‐κB and CMV.
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Reactive oxygen species and 4-hydroxy-2-nonenal (HNE) can directly reactivate CMV, but this process can be inhibited by antioxidants.
“Mechanistic studies show that reactive oxygen species and one of the final products of lipid peroxidation, 4-hydroxy-2-nonenal (HNE), can directly reactivate CMV, but this process can be inhibited by antioxidants (Cinatl et al. 1999; Jaganjac et al. 2010; Speir 2000; Vossen et al. 1997).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Speir 2000
Cites
Schreck, R., RIEBER, P., & Baeuerle, P. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb07761.x · Cited by 3,816 · see citing works
Oxygen radicals and human disease
CROSS, C. E., HALLIWELL, B., BORISH, E. T., PRYOR, W. A., AMES, B. N., SAUL, R. L., McCORD, J. M., & HARMAN, D. (1987) · Annals of Internal Medicine · doi:10.7326/0003-4819-107-4-526 · Cited by 1,856 · see citing works
Aruoma, O. I., Halliwell, B. B., Hoey, B. M., & Butler, J. (1989) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(89)90066-x · Cited by 1,774 · see citing works
Hypercholesterolemia increases endothelial superoxide anion production.
Ohara, Y., Peterson, T. E., & Harrison, D. G. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116491 · Cited by 1,765 · see citing works
Oxygen poisoning and x-irradiation: a mechanism in common
Gerschman, R., Gilbert, D. L., Nye, S. W., Dwyer, P., & Fenn, W. O. (1954) · Science · doi:10.1126/science.119.3097.623 · Cited by 961 · see citing works
Potential Role of Human Cytomegalovirus and p53 Interaction in Coronary Restenosis
Speir, E. H., Modali, R., Huang, E., Leon, M. B., Shawl, F. A., Finkel, T., & Epstein, S. E. (1994) · Science · doi:10.1126/science.8023160 · Cited by 753 · see citing works
Self-citationReactive oxygen species and programmed cell death
Jacobson, M. D. (1996) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(96)20008-8 · Cited by 753 · see citing works
Xanthine oxidase and neutrophil infiltration in intestinal ischemia
Grisham, M. B., Hernandez, L. A., & Granger, D. N. (1986) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1986.251.4.g567 · Cited by 722 · see citing works
Endogenous Oxidative DNA Damage, Aging, and Cancer
Ames, B. N. (1989) · Free Radical Research Communications · doi:10.3109/10715768909087933 · Cited by 708 · see citing works
Meier, B., Radeke, H. H., Selle, S., Younes, M., Sies, H., Resch, K., & Habermehl, G. (1989) · Biochemical Journal · doi:10.1042/bj2630539 · Cited by 650 · see citing works
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.Preprint
Baeuerle, P. A., & Baltimore, D. (1989) · Genes & Development · doi:10.1101/gad.3.11.1689 · Cited by 478 · see citing works
Redox modulation of p53 conformation and sequence-specific DNA binding in vitro.
Hainaut, P. L., & Milner, J. (1993) · PubMed · Cited by 408 · see citing works
Akaike, T., Ando, M., Oda, T., Doi, T., Ijiri, S., Araki, S., & Maeda, H. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114499 · Cited by 333 · see citing works
Vogelstein, B. (1990) · Nature · doi:10.1038/348681a0 · Cited by 332 · see citing works
Cherrington, J. M., & Mocarski, E. S. (1989) · Journal of Virology · doi:10.1128/jvi.63.3.1435-1440.1989 · Cited by 309 · see citing works
Segal, A. W. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114083 · Cited by 282 · see citing works
Oxidation pathways for the intracellular probe 2′,7′-dichlorofluorescin
Zhu, H., Bannenberg, G. L., Moldéus, P., & Shertzer, H. G. (1994) · Archives of Toxicology · doi:10.1007/s002040050118 · Cited by 260 · see citing works
Yurochko, A. D., Kowalik, T. F., Huong, S.-M., et al. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5391-5400.1995 · Cited by 256 · see citing works
A p53-independent Pathway for Activation of WAF1/CIP1 Expression Following Oxidative Stress
Russo, T., Zambrano, N., Esposito, F., Ammendola, R., Cimino, F., Fiscella, M., Jackman, J., O'Connor, P. M., Anderson, C. W., & Appella, E. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29386 · Cited by 246 · see citing works
Stenberg, R. M., Fortney, J. E., Barlow, S. W., et al. (1990) · Journal of Virology · doi:10.1128/jvi.64.4.1556-1565.1990 · Cited by 194 · see citing works
Finco, T. S., & Baldwin, A. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)46756-1 · Cited by 186 · see citing works
Possible Role of Cytomegalovirus in Atherogenesis
Melnick, J. L. (1990) · JAMA · doi:10.1001/jama.1990.03440160066039 · Cited by 175 · see citing works
Speir, E. H., Yu, Z., Ferrans, V. J., Huang, E., & Epstein, S. E. (1998) · Circulation Research · doi:10.1161/01.res.83.2.210 · Cited by 167 · see citing works
Self-citationHuman cytomegalovirus. III. Virus-induced DNA polymerase
Huang, E. S. (1975) · Journal of Virology · doi:10.1128/jvi.16.2.298-310.1975 · Cited by 150 · see citing works
Kowalik, T. F., Wing, B., Haskill, J. S., Azizkhan, J. C., Baldwin, A. S., & Huang, E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.3.1107 · Cited by 150 · see citing works
Grundy, J. E., McKeating, J. A., Ward, P., et al. (1987) · Journal of General Virology · doi:10.1099/0022-1317-68-3-793 · Cited by 135 · see citing works
Immunohistochemical localization of xanthine oxidase in human cardiac and skeletal muscle
Hellsten, Y. (1993) · Histochemistry and Cell Biology · doi:10.1007/bf00269094 · Cited by 123 · see citing works
Speir, E. H., Shibutani, T., Yu, Z., Ferrans, V. J., & Epstein, S. E. (1996) · Circulation Research · doi:10.1161/01.res.79.6.1143 · Cited by 118 · see citing works
Self-citationGrech, E. D., Dodd, N. J. F., Jackson, M. J., et al. (1996) · The American Journal of Cardiology · doi:10.1016/s0002-9149(96)90580-9 · Cited by 99 · see citing works
Oxypurinol as an inhibitor of xanthine oxidase-catalyzed production of superoxide radical
Spector, T. (1988) · Biochemical Pharmacology · doi:10.1016/0006-2952(88)90739-3 · Cited by 73 · see citing works
Sendai virus stimulates chemiluminescence in mouse spleen cells
Peterhans, E. (1979) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(79)90630-2 · Cited by 71 · see citing works
AbuBakar, S., Boldogh, I. R., & Albrecht, T. (1990) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(90)90903-z · Cited by 46 · see citing works
The possible role of cytomegalovirus in atherogenesis.
Bruggeman, C. A., & van Dam-Mieras, M. C. E. (1991) · PubMed · Cited by 42 · see citing works
Albrecht, T., Boldogh, I., Fons, M. P., & Vályi-Nagy, T. (1993) · Frontiers of virology · doi:10.1007/978-3-642-84850-6_19 · Cited by 11 · see citing works
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Is immunosenescence influenced by our lifetime “dose” of exercise?
Turner, J. E. (2016) · Biogerontology · doi:10.1007/s10522-016-9642-z · Cited by 112 · see citing works
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Jaganjac, M., Matijevic, T., Cindric, M., Cipak, A., Mrakovcic, L., Gubisch, W., & Zarkovic, N. (2010) · Acta Biochimica Polonica · doi:10.18388/abp.2010_2392 · Cited by 31 · see citing works
- Authors
- SPEIR, E.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- SPEIR, EDITH
- Venue
- Annals of the New York Academy of Sciences
- Publisher
- Wiley
- Published
- 2000-01
- Volume
- 899
- Issue
- 1
- Pages
- 363-374
- ISSN
- 0077-8923 (ISSN-L)
- 1749-6632
- OpenAlex
- W1965361052
- Cited by
- 56
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 1 · 2012: 2
- FWCI
- 1.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of the New York Academy of Sciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Keywords
- human cytomegalovirus, reactive oxygen species, oxidative stress, atherosclerosis, atherogenesis, vascular smooth muscle cells, NF-κB, viral gene expression, host-virus interaction, antioxidants, aspirin, inflammation
- MeSH terms
- Animals, Antioxidants, Base Sequence, Cytomegalovirus, Humans, Hydrogen Peroxide, Viral Proteins, Xanthine Oxidase, Gene Expression Regulation, Viral, NF-kappa B, Reactive Oxygen Species, Immediate-Early Proteins, DNA Primers, Xanthine
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