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Cited by 27Cytomegalovirus and herpesvirus researchHerpesvirus Infections and TreatmentsViral-associated cancers and disorders

Proinflammatory Potential of Cytomegalovirus Infection

Cinatl Jr., J., Vogel, J.-U., Kotchetkov, R., Scholz, M., Doerr, H.W.·1999·Intervirology
DOI 10.1159/000053980
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Abstract

We observed the effects of antiviral therapy on CMV and/or oxidative-stress-induced stimulation of proinflammatory molecules including interleukin-8 (IL-8), melanoma growth stimulatory activity-α (GRO-α) and intercellular adhesion molecule 1 (ICAM-1) using human foreskin fibroblasts. Ganciclovir, foscarnet or cidofovir completely suppressed virus replication, as demonstrated by CMV late (L) antigen production. These drugs did not influence CMV immediate-early (IE) antigen expression and had no effects on CMV-induced cellular changes in IL-8, GRO-α and ICAM-1 levels. Phosphorothioate oligonucleotide (ISIS 2922) suppressed both CMV IE and L antigen by 99%. ISIS 2922 completely suppressed CMV-induced upregulation of both chemokines and ICAM-1. Induction of oxidative stress by H 2 O 2 upregulated IL-8 expression. Oxidative stress and CMV infection showed synergistic effects on IL-8 expression. ISIS 2922 only partially inhibited the upregulation of IL-8 in infected cells treated with H 2 O 2, whereas cotreatment with ISIS 2922 and antioxidants inhibited the upregulation almost completely. The results showed that inhibition of CMV IE expression alone or in combination with antioxidants is promising for the treatment of CMV disease.

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Crossref · 10.1159/000053980

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  • Reactive oxygen species and 4-hydroxy-2-nonenal (HNE) can directly reactivate CMV, but this process can be inhibited by antioxidants.

    “Mechanistic studies show that reactive oxygen species and one of the final products of lipid peroxidation, 4-hydroxy-2-nonenal (HNE), can directly reactivate CMV, but this process can be inhibited by antioxidants (Cinatl et al. 1999; Jaganjac et al. 2010; Speir 2000; Vossen et al. 1997).”

    From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Cinatl et al. 1999

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Authors
Cinatl Jr., J., Vogel, J.-U., Kotchetkov, R., Scholz, M., & Doerr, H. W.
Affiliations
Goethe University Frankfurt (DE)
ORCID
Venue
Intervirology
Publisher
S. Karger AG
Published
1999
Volume
42
Issue
5-6
Pages
419-424
ISSN
  • 0300-5526 (ISSN-L)
  • 1423-0100
DOI
10.1159/000053980
OpenAlex
W1966085723
Cited by
27
References
37
Citations by year
2021: 1 · 2020: 1 · 2019: 1 · 2016: 2 · 2015: 1 · 2014: 1
FWCI
1.09
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Intervirology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Frankfurter Stiftung für krebskranke Kinder
  • Hilfe für krebskranke Kinder Frankfurt
  • Gastroenterological Society of Australia
Topics
  • Health Sciences › Medicine › Epidemiology › Cytomegalovirus and herpesvirus research
  • Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
  • Health Sciences › Medicine › Oncology › Viral-associated cancers and disorders
Keywords
cytomegalovirus infection, inflammatory cytokines, interleukin-8, CXCL1, ICAM-1, oxidative stress, hydrogen peroxide, antiviral therapy, ganciclovir, foscarnet, cidofovir, immediate early antigen, late antigen, antioxidants, human foreskin fibroblasts, chemokines
MeSH terms
Antigens, Viral, Antioxidants, Antiviral Agents, Cytomegalovirus Infections, Cytomegalovirus, Humans, Inflammation, Oxidation-Reduction, Thionucleotides, Cytokines, Immediate-Early Proteins, Oxidative Stress

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