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Identification of a transforming gene of human papillomavirus type 16
Abstract
Previously, we observed sequential two-step alteration, growth stimulation, and progression to a more malignant state in NIH 3T3 cells transfected by human papillomavirus type 16 (HPV-16) DNA. In this study, we prepared a cDNA library from RNA extracted from cells transfected with the HPV-16 DNA and isolated cDNA clones which had growth-stimulating activity. Analysis of these cDNA clones indicated that the E7 open reading frame alone is responsible for inducing both steps of this cell transformation.
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“subsequently, E7 was recognized as the major transforming protein of high-risk HPVs, using mutational analyses in transformation assays [52,79,80,81,82,83,84]”
From The Not-So-Good, the Bad and the Ugly: HPV E5, E6 and E7 Oncoproteins in the Orchestration of Carcinogenesis (2021) · cites this paper as [81]
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Research works printed but not linked: 8
- [8]8. Öurst, M., L. Gissmann, H. Ikenberg, and H. zur Hausen. 1983. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80:3812–3815.
- [9]9. Dürst, M., E. Schwarz, and L. Gissmann. 1986. Integration and persistance of human papillomavirus DNA in genital tumors, p. 273–280. In R. Peto and H. zur Hausen (ed.), Banbury report 21: viral etiology of cervical cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- [12]12. Gissmann, L., and A. Schneider. 1986. Human papillomavirus DNA in preneoplastic and neoplastic genital lesions, p. 217–224. In R. Peto and H. zur Hausen (ed.), Banbury report 21: viral etiology of cervical cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
- [18]18. Lehn, H., P. Krieg, and G. Sauer. 1985. Papillomavirus genomes in human cervical tumors: analysis of their transcriptional activity. Proc. Natl. Acad. Sci. USA 82:5540–5544.
- [24]24. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463–5467.
- [29]29. Smotkin, D., and F. O. Wettstein. 1986. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA 83:4680–4684.
- [32]32. Yang, Y.-C., H. Okayama, and P. M. Howley. 1985. Bovine papillomavirus contains multiple transforming genes. Proc. Natl. Acad. Sci. USA 82:1030–1034.
- [34]34. zur Hausen, H. 1986. Papillomaviruses in human urogenital cancer: established results and prospects for the future, p. 327–332. In R. Peto and H. zur Hausen (ed.), Banbury report 21: viral etiology of cervical cancer. Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
Cited by
The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
Scheffner, M., Werness, B. A., Huibregtse, J. M., Levine, A. J., & Howley, P. M. (1990) · Cell · doi:10.1016/0092-8674(90)90409-8 · Cited by 3,995
Basukala, O., & Banks, L. (2021) · Viruses · doi:10.3390/v13101892 · Cited by 137
Metadata
- Authors
- Tanaka, A., Noda, T., Yajima, H., Hatanaka, M., & Ito, Y.
- Affiliations
- Institute for Virus Research, Kyoto University, Japan.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1989-03
- Volume
- 63
- Issue
- 3
- Pages
- 1465-1469
- ISSN
- 0022-538X
- 1098-5514
- Cited by
- 58
- References
- 0
- Language
- en
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