The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function
Open accessAbstract
The human immunodeficiency virus rev gene product regulates the expression of viral structural genes. It was recently shown that Rev regulates the export of viral structural mRNAs from the nucleus to the cytoplasm. Analysis of Rev subcellular localization reveals marked accumulation in the nucleolus, suggesting a role for the nucleolus in this export process. We report here the identification of amino acid residues critical to the nucleolar localization of Rev. Consistent with this finding, a Rev/beta-galactosidase fusion protein, harboring this region of Rev, localized entirely within the nucleolus. Of most significance, mutations that eliminated nucleolar localization markedly diminished Rev function, even though accumulation in the nucleoplasm was retained. These findings support a model whereby Rev-induced export of human immunodeficiency virus structural mRNAs from the nucleus to the cytoplasm is likely to involve nucleolar events.
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Cites
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Cited by
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The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP
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Metadata
- Authors
- Cochrane, A. W., Perkins, A., & Rosen, C. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-02
- Volume
- 64
- Issue
- 2
- Pages
- 881-885
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1576538493
- Cited by
- 253
- References
- 27
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- green
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- Cochrane, A. W., Perkins, A., & Rosen, C. A. (1990). Identification of sequences important in the nucleolar localization of human immunodeficiency virus Rev: relevance of nucleolar localization to function. Journal of Virology. https://doi.org/10.1128/jvi.64.2.881-885.1990
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
