The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA
Open accessAbstract
All retroviruses contain, in the nucleocapsid domain of the Gag protein, one or two copies of the sequence Cys-X2-Cys-X4-His-X4-Cys. We have generated a series of mutants in the two copies of this motif present in human immunodeficiency virus type 1. These mutants encoded virus particles that were apparently composed of the normal complement of viral proteins but contained only 2 to 20% of the normal level of genomic RNA. No infectivity could be detected in the mutant particles, while 10(5) infectious U were present in an equivalent amount of wild-type particles. Thus, the mutants have another defect in addition to the inefficiency with which they encapsidate genomic RNA. Our results show that both copies of the motif are required for normal RNA packaging and for infectivity. Mutants of this type may have important applications, including nonhazardous materials for research, immunogens in vaccine and immunotherapy studies, and diagnostic reagents.
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DNA sequencing with chain-terminating inhibitors
Sanger, F., Nicklen, S., & Coulson, A. R. (1977) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.74.12.5463 · Cited by 68,572
A new technique for the assay of infectivity of human adenovirus 5 DNA
Graham, F. L., & van der Eb, A. J. (1973) · Virology · doi:10.1016/0042-6822(73)90341-3 · Cited by 9,451
Popovic, M., Sarngadharan, M. G., Read, E., & Gallo, R. C. (1984) · Science · doi:10.1126/science.6200935 · Cited by 3,535
Adachi, A., Gendelman, H. E., Koenig, S., Folks, T., Willey, R., Rabson, A., & Martin, M. A. (1986) · Journal of Virology · doi:10.1128/jvi.59.2.284-291.1986 · Cited by 2,834
Potential Metal-Binding Domains in Nucleic Acid Binding Proteins
Berg, J. M. (1986) · Science · doi:10.1126/science.2421409 · Cited by 1,061
Evidence that the packaging signal of Moloney murine leukemia virus extends into the gag region
Bender, M. A., Palmer, T. D., Gelinas, R. E., & Miller, A. D. (1987) · Journal of Virology · doi:10.1128/jvi.61.5.1639-1646.1987 · Cited by 410
Standardized and simplified nomenclature for proteins common to all retroviruses
Leis, J., Baltimore, D., Bishop, J. M., Coffin, J., Fleissner, E., Goff, S. P., Oroszlan, S., Robinson, H., Skalka, A. M., & Temin, H. M. (1988) · Journal of Virology · doi:10.1128/jvi.62.5.1808-1809.1988 · Cited by 331
Gorelick, R. J., Henderson, L. E., Hanser, J. P., & Rein, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8420 · Cited by 319
Self-citationCovey, S. N. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.2.623 · Cited by 299
Méric, C., & Goff, S. P. (1989) · Journal of Virology · doi:10.1128/jvi.63.4.1558-1568.1989 · Cited by 255
Cited by
HIV-1 Gag proteins: diverse functions in the virus life cycle
Freed, E. O. (1998) · Virology · doi:10.1006/viro.1998.9398 · Cited by 717
Structure of the HIV-1 Nucleocapsid Protein Bound to the SL3 Ψ-RNA Recognition Element
De Guzman, R. N., Wu, Z. R., Stalling, C. C., Pappalardo, L., Borer, P. N., & Summers, M. F. (1998) · Science · doi:10.1126/science.279.5349.384 · Cited by 659
Hill, C. P., Worthylake, D., Bancroft, D. P., Christensen, A. M., & Sundquist, W. I. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3099 · Cited by 473
Structural biology of HIV 1 1Edited by P. E. Wright
Turner, B. G., & Summers, M. F. (1999) · Journal of Molecular Biology · doi:10.1006/jmbi.1998.2354 · Cited by 470
Chertova, E., Chertov, O., Coren, L. V., Roser, J. D., Trubey, C. M., Bess, J. W., Sowder, R. C., Barsov, E., Hood, B. L., Fisher, R. J., et al. (2006) · Journal of Virology · doi:10.1128/jvi.01013-06 · Cited by 462
Self-citation
Metadata
- Authors
- Gorelick, R. J., Nigida, S. M., Bess, J. W., Arthur, L. O., Henderson, L. E., & Rein, A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-07
- Volume
- 64
- Issue
- 7
- Pages
- 3207-3211
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1867231822
- Cited by
- 386
- References
- 16
- FWCI
- 5.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Gorelick, R. J., Nigida, S. M., Bess, J. W., Arthur, L. O., Henderson, L. E., & Rein, A. (1990). Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. Journal of Virology. https://doi.org/10.1128/jvi.64.7.3207-3211.1990
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
