The DOI matches its Crossref record.
Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells
Open accessAbstract
Both CD4+ and CD8+ T cells are required for the clearance of virus from the central nervous system following infection with the JHM strain of mouse hepatitis virus. Development of antiviral antibodies requires the presence of CD4+ T cells but appears to play a minimal role in the reduction of virus. The data presented are consistent with the hypothesis that clearance of JHM virus is mediated by virus-specific CD8+ T cells, which appear to require the presence of CD4+ T cells.
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Citations
Cited by
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T cell-mediated immune response to respiratory coronaviruses
Channappanavar, R., Zhao, J., & Perlman, S. (2014) · Immunologic Research · doi:10.1007/s12026-014-8534-z · Cited by 512
Channappanavar, R., Fett, C., Zhao, J., Meyerholz, D. K., & Perlman, S. (2014) · Journal of Virology · doi:10.1128/jvi.01505-14 · Cited by 411
Zhao, J., Zhao, J., & Perlman, S. (2010) · Journal of Virology · doi:10.1128/jvi.01049-10 · Cited by 340
Lessons for COVID-19 immunity from other coronavirus infections
Sariol, A., & Perlman, S. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.005 · Cited by 317
Metadata
- Authors
- Williamson, J. S., & Stohlman, S. A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1990-09
- Volume
- 64
- Issue
- 9
- Pages
- 4589-4592
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1514436302
- Cited by
- 184
- References
- 0
- FWCI
- 20.23
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells. https://app.cochat.ai/papers/10.1128/jvi.64.9.4589-4592.1990
- The paper
- Williamson, J. S., & Stohlman, S. A. (1990). Effective clearance of mouse hepatitis virus from the central nervous system requires both CD4+ and CD8+ T cells. Journal of Virology. https://doi.org/10.1128/jvi.64.9.4589-4592.1990
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
