Cited by 319SARS-CoV-2 and COVID-19 ResearchImmune responses and vaccinationsAnimal Virus Infections Studies

Lessons for COVID-19 immunity from other coronavirus infections

Open access
Sariol, Alan, Perlman, Stanley·2020·Immunity

Abstract

A key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective vaccine. Development of a vaccine requires knowledge of what constitutes a protective immune response and also features that might be pathogenic. Protective and pathogenic aspects of the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood, partly because the virus has infected humans for only 6 months. However, insight into coronavirus immunity can be informed by previous studies of immune responses to non-human coronaviruses, common cold coronaviruses, and SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we review the literature describing these responses and discuss their relevance to the SARS-CoV-2 immune response.

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Crossref · 10.1016/j.immuni.2020.07.005

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  • Previous experience with SARS-CoV-1 showed that CD8+ and CD4+ memory T cells were detectable as late as 17 years post-infection, while neutralizing antibody titers had waned substantially by 1 year after infection.

    “previous experience with the closely related SARS-CoV-1, showed that CD8+ and CD4+ memory T cells were detectable as late as 17 years post-infection, while neutralizing antibody titers had waned substantially by 1 year after infection [69,70]”

    From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [69]

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Research works printed but not linked: 1

  1. Saif LJ, Wang Q, Vlasova AN, Jung K, and Xiao S (2019). Coronaviruses. In Diseases of Swine, (John Wiley & Sons, Ltd), pp. 488– 523.

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Authors
Sariol, A., & Perlman, S.
Affiliations
University of Iowa (US)
Corresponding author
Perlman, Stanley
Venue
Immunity
Publisher
Elsevier BV
Published
2020-08
Volume
53
Issue
2
Pages
248-263
ISSN
1074-7613 (ISSN-L)
OpenAlex
W3041450977
Cited by
317
References
244
Citations by year
2026: 4 · 2025: 15 · 2024: 17 · 2023: 29 · 2022: 68 · 2021: 138 · 2020: 46
FWCI
3.34
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health (PO1 AI060699, RO1 AI129269)
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Keywords
COVID-19 pandemic, SARS-CoV-2, protective immune response, SARS-CoV, MERS-CoV, common cold coronaviruses, vaccine development
MeSH terms
Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Humans, Pneumonia, Viral, Viral Vaccines, Coronavirus Infections, CD8-Positive T-Lymphocytes, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Adaptive Immunity, Pandemics, Middle East Respiratory Syndrome Coronavirus

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