The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells
Open accessAbstract
Some possible ways in which replication of plasmids containing the Epstein-Barr virus (EBV) plasmid maintenance origin, oriP, might be controlled were investigated. Virtually all plasmid molecules were found to replicate no more than once per cell cycle, whether replication was observed after stable introduction of the plasmids into cells by drug selection or during the first few cell divisions after introducing the DNA into cells. The presence in the cells of excess amounts of EBNA1, the only viral protein needed for oriP function, did not increase the number of oriP-replicated plasmids maintained by cells under selection. In the cell lines studied, EBNA1 and oriP seem to lack the capacity to override the cellular controls that limit DNA replication to one initiation event per DNA molecule per S phase. The multicopy status of EBV-derived, selectable plasmids appears to result from the initial uptake by cells of large numbers of plasmid molecules, the efficient maintenance of these plasmids, and the pressure of genetic selection against plasmid loss. Other unknown controls must be responsible for the amplification of EBV genomes soon after latent infection of cells.
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Cites
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Epstein–Barr virus latent genes
Kang, M.-S., & Kieff, E. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.84 · Cited by 361
Efficient Feeder-Free Episomal Reprogramming with Small Molecules
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Metadata
- Authors
- Yates, J. L., & Guan, N.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1991-01
- Volume
- 65
- Issue
- 1
- Pages
- 483-488
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1786573368
- Cited by
- 292
- References
- 24
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Yates, J. L., & Guan, N. (1991). Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cells. Journal of Virology. https://doi.org/10.1128/jvi.65.1.483-488.1991
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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