The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein
Open accessAbstract
A detailed kinetic and quantitative analysis of the early and late biosynthetic events undergone by the human immunodeficiency virus type 1 envelope protein expressed by a recombinant vaccinia virus was performed. Early folding events that occurred in the endoplasmic reticulum included disulfide bond formation (t1/2 approximately 10 min), folding of envelope protein into a form competent to bind CD4 (t1/2 approximately 15 min), and specific and transient association and dissociation with GRP78-BiP (t1/2 approximately 25 min). After initial folding, envelope protein monomers formed noncovalently associated dimers with high efficiency (t1/2 approximately 30 min). Studies with brefeldin A, a compound that inhibits endoplasmic reticulum-to-Golgi transport, suggested that assembly occurred in the endoplasmic reticulum while cleavage of gp160 into gp120/gp41 subunits occurred in a post-endoplasmic reticulum compartment. Transport to the Golgi was monitored by modification of N-linked sugars to forms partially resistant to endoglycosidase H. The kinetics of endoglycosidase H resistance were nearly identical to the kinetics of gp160 cleavage (t1/2 approximately 80 min). Cleavage efficiency was strongly cell type dependent, ranging from 13 to 70%. By contrast, approximately 50% of the gp120 generated by the cleavage event was shed (t1/2 approximately 120 min) regardless of the cell type used. The results are discussed in terms of the overall biosynthetic pathway of the envelope protein and provide a framework with which to assess the effects of mutations on structure and function.
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Cites
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Cited by
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Metadata
- Authors
- Earl, P. L., Moss, B., & Doms, R. W.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1991-04
- Volume
- 65
- Issue
- 4
- Pages
- 2047-2055
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1762774688
- Cited by
- 327
- References
- 41
- FWCI
- 6.27
- Type
- journal article
- Language
- en
- Open access
- green
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- Earl, P. L., Moss, B., & Doms, R. W. (1991). Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein. Journal of Virology. https://doi.org/10.1128/jvi.65.4.2047-2055.1991
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