Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

Brown, P H; Tiley, L S; Cullen, B R

doi:10.1128/jvi.65.6.3340-3343.1991

Cited by 85RNA Research and SplicingHIV Research and TreatmentRNA and protein synthesis mechanisms

Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

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Brown, P H, Tiley, L S, Cullen, B R·1991·Journal of Virology

DOI 10.1128/jvi.65.6.3340-3343.1991PMC PMC240993

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Abstract

During transcription of the human immunodeficiency virus type 1 provirus, polyadenylation signals present in the 5' long terminal repeat (LTR) are disregarded while the identical polyadenylation signals present in the 3' LTR are utilized efficiently. As both transcribed LTR sequences contain all signals known to be required for efficient polyadenylation, the basis for this differential utilization has been unclear. Here, we describe experiments that suggest that transcribed sequences present within the human immunodeficiency virus type 1 LTR U3 region act in cis to enhance polyadenylation within the 3' LTR.

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Specific sequences in the U3 region upstream of the conserved hexamer boost polyadenylation by improving CPSF binding both in vitro and in vivo.
“These sequences have been shown to boost polyadenylation by improving CPSF binding both in vitro as well as in vivo (Brown et al. 1991, Valsamakis et al. 1992, Ashe et al. 1995, Gilmartin et al. 1995, Graveley and Gilmartin 1996).”
From Beyond reverse transcription: molecular mechanisms and emerging paradigms in retroviral replication (2026) · cites this paper as Brown et al. 1991

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“These sequences have been shown to boost polyadenylation by improving CPSF binding both in vitro as well as in vivo (Brown et al. 1991 , Valsamakis et al. 1992 , Ashe et al. 1995 , Gilmartin et al. 1995 , Graveley and Gilmartin 1996 ).”
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Authors: Brown, P. H., Tiley, L. S., & Cullen, B. R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Brown, P H
Tiley, L S
Cullen, B R
Venue: Journal of Virology
Publisher: American Society for Microbiology
Published: 1991-06
Volume: 65
Issue: 6
Pages: 3340-3343
ISSN: 0022-538X (ISSN-L)
1098-5514
DOI: 10.1128/jvi.65.6.3340-3343.1991
PMC: PMC240993
OpenAlex: W1878762428
Cited by: 85
References: 15
Citations by year: 2025: 1 · 2024: 2 · 2022: 1 · 2021: 1 · 2019: 3 · 2015: 5 · 2013: 5 · 2012: 1
FWCI: 2.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Virology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
Keywords: HIV-1, long terminal repeat, polyadenylation, 3' LTR, U3 region, cis-regulatory elements, proviral transcription, polyadenylation signal, HIV-1 provirus
MeSH terms: Base Sequence, Cytomegalovirus, Poly A, Promoter Regions, Genetic, RNA, Messenger, HIV-1, Mutagenesis, HIV Long Terminal Repeat

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Efficient polyadenylation within the human immunodeficiency virus type 1 long terminal repeat requires flanking U3-specific sequences

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