VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells
Open accessAbstract
Murine VCAM-1 has been identified as a receptor for the D variant of encephalomyocarditis (EMC-D) virus on vascular endothelial cells from the heart. Monoclonal antibodies to VCAM-1 inhibited infection and lysis of endothelial cells with EMC-D virus. CHO cells transfected with the VCAM-1 gene were susceptible to EMC-D virus lysis, while control CHO cells transfected with the ELAM-1 gene were resistant. Similarly, 35S-labeled EMC-D virus bound to CHO-VCAM cells, and binding was inhibited with anti-VCAM-1 antibodies. Little or no radiolabeled virus bound to CHO-ELAM-1 cells.
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- Authors
- Huber, S. A.
- Affiliations
- University of Vermont (US)
- Corresponding author
- Huber, S A
- ORCID
- Huber, S A
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-06
- Volume
- 68
- Issue
- 6
- Pages
- 3453-3458
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC236847
- OpenAlex
- W2105274196
- Cited by
- 88
- References
- 29
- Citations by year
- 2026: 3 · 2024: 2 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 5.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Virology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Keywords
- VCAM-1, encephalomyocarditis virus, viral receptor, vascular endothelial cells, ELAM-1, receptor binding, monoclonal antibodies, CHO cell transfection, viral infection
- MeSH terms
- Animals, Antibodies, Monoclonal, Encephalomyocarditis virus, Endothelium, Vascular, Cricetinae, Mice, Inbred BALB C, Receptors, Virus, Transfection, Cell Adhesion Molecules, CHO Cells, Cardiovirus Infections, Vascular Cell Adhesion Molecule-1, Mice, In Vitro Techniques
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