Experimental encephalomyocarditis virus infection in small laboratory rodents

Doi, K.

doi:10.1016/j.jcpa.2010.05.001

Cited by 26Viral Infections and Immunology ResearchAnimal Virus Infections StudiesVirology and Viral Diseases

Experimental encephalomyocarditis virus infection in small laboratory rodents

Doi, K.·2011·Journal of Comparative Pathology

DOI 10.1016/j.jcpa.2010.05.001

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Abstract

Encephalomyocarditis virus (EMCV) is a cardiovirus that belongs to the family Picornaviridae. EMCV is an important cause of acute myocarditis in piglets and of fetal death or abortion in pregnant sows. Small rodents, especially rats, have been suspected to be reservoir hosts or carriers. This virus also induces type 1 diabetes mellitus, encephalomyelitis, myocarditis, orchitis and/or sialodacryoadenitis in small laboratory rodents. This paper reviews the pathology and pathogenesis of experimental infection with EMCV in small laboratory rodents.

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EMCV is principally rodent-borne, maintained in nature in wild rats and mice.
“EMCV is believed to be principally rodent-borne, being maintained in nature in wild rats and mice [10–12].”
From Zoological transmission of encephalomyocarditis virus in the United States: Virus evolution, host ecology, and capsid antigenicity derived from an outbreak (2026) · cites this paper as [11]
The natural transmission cycles of EMCV in North America and globally are largely enigmatic.
“Overall, the natural transmission cycles of EMCV in North America (and globally) are largely enigmatic.”
From Zoological transmission of encephalomyocarditis virus in the United States: Virus evolution, host ecology, and capsid antigenicity derived from an outbreak (2026) · cites this paper as [11]
EMCV infection can also lead to reproductive disorders in pregnant mice, testicular lesions (orchitis) in mice and lesions in salivary and lachrymal glands (sialodacryoadenitis).
“EMCV infection can also lead to reproductive disorders in pregnant mice,121 testicular lesions (orchitis) in mice122 and also to lesions in salivary and lachrymal glands (sialodacryoadenitis) (for review see ref. 123).”
From The encephalomyocarditis virus (2012) · cites this paper as [123]

Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477 · see citing works
Interleukin-8 as a macrophage-derived mediator of angiogenesis
Koch, A. E., Polverini, P. J., Kunkel, S. L., Harlow, L. A., DiPietro, L. A., Elner, V. M., Elner, S. G., & Strieter, R. M. (1992) · Science · doi:10.1126/science.1281554 · Cited by 2,135 · see citing works
Biological and clinical aspects of interleukin 6
Hirano, T., Akira, S., Taga, T., & Kishimoto, T. (1990) · Immunology Today · doi:10.1016/0167-5699(90)90173-7 · Cited by 1,063 · see citing works
Picornaviridae : the viruses and their replication
Racaniello, V. R. (2001) · Medical Entomology and Zoology · Cited by 868 · see citing works
An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.
Ruddle, N. H., Bergman, C. M., McGrath, K. M., Lingenheld, E. G., Grunnet, M. L., Padula, S. J., & Clark, R. B. (1990) · The Journal of Experimental Medicine · doi:10.1084/jem.172.4.1193 · Cited by 689 · see citing works
Theiler's virus infection in mice: an unusual biphasic disease process leading to demyelination
Lipton, H. (1975) · Infection and Immunity · doi:10.1128/iai.11.5.1147-1155.1975 · Cited by 644 · see citing works
Regulation of apoptosis by viral gene products
Teodoro, J. G., & Branton, P. E. (1997) · Journal of Virology · doi:10.1128/jvi.71.3.1739-1746.1997 · Cited by 635 · see citing works
Textbook of Diabetes
Pickup, J. C., & Williams, G. H. (1991) · Cited by 573 · see citing works
The Classification and Nomenclature of Viruses
Matthews, R. E. F. (1979) · Intervirology · doi:10.1159/000149025 · Cited by 509 · see citing works
Molecular Biology and Pathogenesis of Viral Myocarditis
Esfandiarei, M., & McManus, B. M. (2008) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathmechdis.3.121806.151534 · Cited by 387 · see citing works
Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulin-dependent diabetes susceptibility.
Horn, G. T., Bugawan, T. L., Long, C. M., & Erlich, H. A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.16.6012 · Cited by 378 · see citing works
Viruses in the Mammalian Male Genital Tract and Their Effects on the Reproductive System
Dejucq‐Rainsford, N., & Jégou, B. (2001) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.65.2.208-231.2001 · Cited by 326 · see citing works
Susceptibility to type I diabetes: HLA-DQ and DR revisited
She, J. (1996) · Immunology Today · doi:10.1016/0167-5699(96)10014-1 · Cited by 318 · see citing works
Diabetes Mellitus: Induction in Mice by Encephalomyocarditis Virus
Craighead, J. E., & McLane, M. F. (1968) · Science · doi:10.1126/science.162.3856.913 · Cited by 298 · see citing works
Lymphotoxin and tumor necrosis factor-alpha production by myelin basic protein-specific T cell clones correlates with encephalitogenicity
Powell, M. B., Mitchell, D. J., Lederman, J. R., Buckmeier, J. A., Zamvil, S. S., Graham, M., Ruddle, N. H., & Steinman, L. (1990) · International Immunology · doi:10.1093/intimm/2.6.539 · Cited by 286 · see citing works
T lymphocyte recruitment by interleukin-8 (IL-8). IL-8-induced degranulation of neutrophils releases potent chemoattractants for human T lymphocytes both in vitro and in vivo.
Taub, D. D., Anver, M. R., Oppenheim, J. J., Longo, D. L., & Murphy, W. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118625 · Cited by 281 · see citing works
Virus infection activates IL-1 beta and IL-18 production in human macrophages by a caspase-1-dependent pathway.
Pirhonen, J., Sareneva, T., Kurimoto, M., Julkunen, I., & Matikainen, S. (1999) · PubMed · Cited by 274 · see citing works
Persistent infection of oligodendrocytes in Theiler's virus‐induced encephalomyelitis
Rodriguez, M., Leibowitz, J. L., & Lampert, P. W. (1983) · Annals of Neurology · doi:10.1002/ana.410130409 · Cited by 266 · see citing works
Molecular Biology and Pathogenesis of Viral Myocarditis
Esfandiarei, M., & McManus, B. M. (2007) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev.pathol.3.121806.151534 · Cited by 259 · see citing works
Viral infections as potential triggers of type 1 diabetes
van der Werf, N., Kroese, F., Rozing, J., & Hillebrands, J. (2007) · Diabetes/Metabolism Research Reviews · doi:10.1002/dmrr.695 · Cited by 247 · see citing works
Virus Infection Activates IL-1β and IL-18 Production in Human Macrophages by a Caspase-1-Dependent Pathway
Pirhonen, J., Sareneva, T., Kurimoto, M., Julkunen, I., & Matikainen, S. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.12.7322 · Cited by 236 · see citing works
The encephalomyocarditis virus
Carocci, M., & Bakkali-Kassimi, L. (2012) · Virulence · doi:10.4161/viru.20573 · Cited by 231 · see citing works
Autoantibodies specific for the cardiac myosin isoform are found in mice susceptible to Coxsackievirus B3-induced myocarditis.
Neu, N., Beisel, K. W., Traystman, M. D., Rose, N. R., & Craig, S. W. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.8.2488 · Cited by 227 · see citing works
Virus-induced diabetes mellitus. XVIII. Inhibition by a nondiabetogenic variant of encephalomyocarditis virus.
Yoon, J. W., McClintock, P. R., Onodera, T., & Notkins, A. L. (1980) · The Journal of Experimental Medicine · doi:10.1084/jem.152.4.878 · Cited by 200 · see citing works
Virus infections of porcines.
Pensaert, M. B. (1989) · Elsevier eBooks · Cited by 200 · see citing works
Persistent Expression of Cytokine in the Chronic Stage of Viral Myocarditis in Mice
Shioi, T., Matsumori, A., & Sasayama, S. (1996) · Circulation · doi:10.1161/01.cir.94.11.2930 · Cited by 173 · see citing works
Therapeutic effect of anti-tumor necrosis factor-alpha antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus.
Yamada, T., Matsumori, A., & Sasayama, S. (1994) · Circulation · doi:10.1161/01.cir.89.2.846 · Cited by 164 · see citing works
A Filter-Passing Agent Producing Interstitial Myocarditis in Anthropoid Apes and Small Animals
Helwig, F. C., & Schmidt, C. (1945) · Science · doi:10.1126/science.102.2637.31 · Cited by 155 · see citing works
The role of viruses in Type I diabetes: two distinct cellular and molecular pathogenic mechanisms of virus-induced diabetes in animals
Jun, H., & Yoon, J. W. (2001) · Diabetologia · doi:10.1007/s001250051614 · Cited by 149 · see citing works
Canine abortion caused by Brucella canis.
Carmichael, L. E., & Kenney, R. M. (1968) · PubMed · Cited by 143 · see citing works
Treatment of Experimental Viral Myocarditis With Interleukin-10
Nishio, R., Matsumori, A., Shioi, T., Ishida, H., & Sasayama, S. (1999) · Circulation · doi:10.1161/01.cir.100.10.1102 · Cited by 140 · see citing works
Orchitis and human immunodeficiency virus type 1 infected cells in reproductive tissues from men with the acquired immune deficiency syndrome.
Pudney, J. A., & Anderson, D. (1991) · PubMed · Cited by 139 · see citing works
HIV-1 nucleic acids localize to the spermatogonia and their progeny. A study by polymerase chain reaction in situ hybridization.
Nuovo, G. J., Becker, J. L., Simsir, A., et al. (1994) · PubMed · Cited by 137 · see citing works
Successful therapy of Theiler's virus-induced demyelination (DA strain) with monoclonal anti-Lyt-2 antibody.
Rodriguez, M., & Sriram, S. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.9.2950 · Cited by 126 · see citing works
Tumor Necrosis Factor-α (TNF-α) Plays a Protective Role in Acute Viral Myocarditis in Mice
Wada, H., Saito, K., Kanda, T., Kobayashi, I., Fujii, H., Fujigaki, S., Maekawa, N., Takatsu, H., Fujiwara, H., Sekikawa, K., et al. (2001) · Circulation · doi:10.1161/01.cir.103.5.743 · Cited by 123 · see citing works
Fatal Disease of Swine Due to Encephalomyocarditis Virus
Murnane, T. G., Craighead, J. E., Mondragon, H., et al. (1960) · Science · doi:10.1126/science.131.3399.498 · Cited by 123 · see citing works
Overexpression of interleukin-6 aggravates viral myocarditis: impaired increase in tumor necrosis factor-alpha.
Tanaka, T., Kanda, T., McManus, B. M., Kanai, H., Akiyama, H., Sekiguchi, K., Yokoyama, T., & Kurabayashi, M. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2001.1428 · Cited by 92 · see citing works
Gamma Interferon Is Critical for Neuronal Viral Clearance and Protection in a Susceptible Mouse Strain following Early Intracranial Theiler's Murine Encephalomyelitis Virus Infection
Rodriguez, M., Zoecklein, L. J., Howe, C. L., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.22.12252-12265.2003 · Cited by 91 · see citing works
VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells
Huber, S. A. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3453-3458.1994 · Cited by 88 · see citing works
Testicular dysfunction in human immunodeficiency virus—infected men
Poretsky, L., Can, S., & Zumoff, B. (1995) · Metabolism · doi:10.1016/0026-0495(95)90250-3 · Cited by 86 · see citing works
Beneficial Effects of Amlodipine in a Murine Model of Congestive Heart Failure Induced by Viral Myocarditis
Wang, W. Z., Matsumori, A., Yamada, T., et al. (1997) · Circulation · doi:10.1161/01.cir.95.1.245 · Cited by 84 · see citing works
NF-κB-Mediated Inhibition of Apoptosis Is Required for Encephalomyocarditis Virus Virulence: a Mechanism of Resistance in p50 Knockout Mice
Schwarz, E. M., Badorff, C., Hiura, T. S., Wessely, R., Badorff, A., Verma, I. M., & Knowlton, K. U. (1998) · Journal of Virology · doi:10.1128/jvi.72.7.5654-5660.1998 · Cited by 84 · see citing works
Modification of Viral Myocarditis in Mice by Interleukin-6
Kanda, T., McManus, J. E. W., Nagai, R., Imai, S., Suzuki, T., Yang, D., McManus, B. M., & Kobayashi, I. (1996) · Circulation Research · doi:10.1161/01.res.78.5.848 · Cited by 83 · see citing works
Characterization of the inflammatory response in the central nervous system of mice susceptible or resistant to demyelination by Theiler's virus.
Lindsley, M. D., & Rodriguez, M. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.8.2677 · Cited by 82 · see citing works
Effect of p38 Mitogen-Activated Protein Kinase on the Replication of Encephalomyocarditis Virus
Hirasawa, K., Kim, A., Han, H.-S., et al. (2003) · Journal of Virology · doi:10.1128/jvi.77.10.5649-5656.2003 · Cited by 81 · see citing works
Innate immune response to encephalomyocarditis virus infection mediated by CD1d
Exley, M. A., Bigley, N. J., Cheng, O., Shaulov, A., Tahir, S. M., Carter, Q. L., García, J. A., Wang, C., Patten, K., Stills, H. F., et al. (2003) · Immunology · doi:10.1111/j.1365-2567.2003.01779.x · Cited by 80 · see citing works
An encephalomyocarditis virus epizootic in a baboon colony.
Gb, H., Soike, K. F., Tm, B., Kd, C., Davis, H., Butcher, W. I., & Gauntt, C. J. (1992) · PubMed · Cited by 76 · see citing works
Inhibitory role of the host apoptogenic gene PKR in the establishment of persistent infection by encephalomyocarditis virus in U937 cells
Yeung, M. C., Chang, D. L., Camantigue, R. E., & Lau, A. S. Y. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.11860 · Cited by 74 · see citing works
Genomic differences between the diabetogenic and nondiabetogenic variants of encephalomyocarditis virus
Bae, Y., Eun, H., & Yoon, J. (1989) · Virology · doi:10.1016/0042-6822(89)90379-6 · Cited by 73 · see citing works
Immunologic behavior of lymphocytes in experimental viral myocarditis: significance of T lymphocytes in the severity of myocarditis and silent myocarditis in BALB/c-nu/nu mice.
Kishimoto, C., Kuribayashi, K., Masuda, T., Tomioka, N., & Kawai, C. (1985) · Circulation · doi:10.1161/01.cir.71.6.1247 · Cited by 73 · see citing works
Pathogenicity of the M and E variants of the encephalomyocarditis (EMC) virus. I. Myocardiotropic and neurotropic properties.
Craighead, J. E. (1966) · PubMed · Cited by 73 · see citing works
Diabetes in the New Millennium
Turtle, J. R., Kaneko, T., & Osato, S. (1999) · Medical Entomology and Zoology · Cited by 68 · see citing works
Immunoglobulins stimulate central nervous system remyelination: electron microscopic and morphometric analysis of proliferating cells.
Rodriguez, M. (1991) · PubMed · Cited by 67 · see citing works
An outbreak of encephalomyocarditis-virus infection in free-ranging African elephants in the Kruger National Park
Grobler, D., Raath, J. P., Braack, L., Keet, D. F., Gerdes, G. H., Barnard, B. J. H., Kriek, N. P. J., Jardine, J., & Swanepoel, R. (1995) · PubMed · doi:10.5281/zenodo.13537728 · Cited by 64 · see citing works
Virus-induced autoimmunity: Epitope spreading to myelin autoepitopes in theiler's virus infection of the central nervous system
Miller, S. D., Katz‐Levy, Y., Neville, K. L., & Vanderlugt, C. L. (2001) · Advances in virus research · doi:10.1016/s0065-3527(01)56008-x · Cited by 63 · see citing works
Genetic differences in susceptibility of pancreatic β cells to virus-induced diabetes mellitus
Yoon, J., Lesniak, M. A., Fußgänger, R., & Notkins, A. L. (1976) · Nature · doi:10.1038/264178a0 · Cited by 62 · see citing works
Possible role of macrophage-derived soluble mediators in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice
Hirasawa, K., Jun, H., Maeda, K., Kawaguchi, Y., ITAGAKI, S., Mikami, T., Baek, H. S., Doi, K., & Yoon, J. (1997) · Journal of Virology · doi:10.1128/jvi.71.5.4024-4031.1997 · Cited by 61 · see citing works
Self-citation
High resolution in situ hybridization to determine the cellular distribution of lymphocytic choriomeningitis virus RNA in the tissues of persistently infected mice: relevance to arenavirus disease and mechanisms of viral persistence
Fazakerley, J. K., Southern, P. J., Bloom, F. E., et al. (1991) · Journal of General Virology · doi:10.1099/0022-1317-72-7-1611 · Cited by 61 · see citing works
Porcine encephalomyocarditis virus persists in pig myocardium and infects human myocardial cells
Brewer, L. A., Lwamba, H. C. M., Murtaugh, M. P., Palmenberg, A. C., Brown, C., & Njenga, M. K. (2001) · Journal of Virology · doi:10.1128/jvi.75.23.11621-11629.2001 · Cited by 58 · see citing works
Transmission and pathogenicity of encephalomyocarditis virus (EMCV) among rats
Spyrou, V., Maurice, H., CharalambosBillinis, Papanastassopoulou, M., Psalla, D., Nielen, M., Koenen, F., & Papadopoulos, O. (2004) · Veterinary Research · doi:10.1051/vetres:2003044 · Cited by 56 · see citing works
The natural history of encephalomyocarditis virus-induced myositis and myocarditis in mice. Viral persistence demonstrated by in situ hybridization.
Cronin, M. E., Love, L. A., Miller, F. W., McClintock, P. R., & Plötz, P. H. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.168.5.1639 · Cited by 56 · see citing works
Long-term complications of virus-induced diabetes mellitus in mice
Yoon, J., Rodrigues, M. M., Currier, C. A., et al. (1982) · Nature · doi:10.1038/296566a0 · Cited by 55 · see citing works
Direct Involvement of Macrophages in Destruction of β-Cells Leading to Development of Diabetes in Virus-Infected Mice
Baek, H.-S., & Yoon, J. (1991) · Diabetes · doi:10.2337/diab.40.12.1586 · Cited by 53 · see citing works
Heat-shock protein induction in adriamycin and picornavirus-infected cardiocytes.
Huber, S. A. (1992) · PubMed · Cited by 53 · see citing works
Mumps orchitis
Manson, A. L. (1990) · Urology · doi:10.1016/0090-4295(90)80248-l · Cited by 51 · see citing works
Role of macrophages in the pathogenesis of encephalomyocarditis virus-induced diabetes in mice
Baek, H.-S., & Yoon, J. (1990) · Journal of Virology · doi:10.1128/jvi.64.12.5708-5715.1990 · Cited by 50 · see citing works
In vivo significance of T cells in the development of Coxsackievirus B3 myocarditis in mice. Immature but antigen-specific T cells aggravate cardiac injury.
Kishimoto, C., & Abelmann, W. H. (1990) · Circulation Research · doi:10.1161/01.res.67.3.589 · Cited by 50 · see citing works
The Testicular Antiviral Defense System: Localization, Expression, and Regulation of 2′5′ Oligoadenylate Synthetase, Double-Stranded RNA-activated Protein Kinase, and Mx Proteins in the Rat Seminiferous Tubule
Dejucq‐Rainsford, N., Chousterman, S., & Jégou, B. (1997) · The Journal of Cell Biology · doi:10.1083/jcb.139.4.865 · Cited by 46 · see citing works
A Spatial Analysis of the Blood—Brain Barrier Damage in Experimental Allergic Encephalomyelitis
Juhler, M., Blasberg, R. G., Fenstermacher, J. D., Patlak, C. S., & Paulson, O. B. (1985) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1985.82 · Cited by 46 · see citing works
Suppression of Cytokines and Nitric Oxide Production, and Protection Against Lethal Endotoxemia and Viral Myocarditis by a New NF-κB Inhibitor
Matsumori, A., Nunokawa, Y., Yamaki, A., Yamamoto, K., Hwang, M., Miyamoto, T., Hara, M., Nishio, R., Kitaura‐Inenaga, K., & Ono, K. (2003) · European Journal of Heart Failure · doi:10.1016/j.ejheart.2003.10.007 · Cited by 45 · see citing works
Pathogenicity of the M and E variants of the encephalomyocarditis (EMC) virus. II. Lesions of the pancreas, parotid and lacrimal glands.
Craighead, J. E. (1966) · PubMed · Cited by 45 · see citing works
Prevention of Encephalomyocarditis Virus-Induced Diabetes in Mice by Inhibition of the Tyrosine Kinase Signalling Pathway and Subsequent Suppression of Nitric Oxide Production in Macrophages
Hirasawa, K., Jun, H., Han, H. S., Zhang, M. L., Hollenberg, M. D., & Yoon, J. (1999) · Journal of Virology · doi:10.1128/jvi.73.10.8541-8548.1999 · Cited by 44 · see citing works
Animal models of picornavirus-induced autoimmune disease: their possible relevance to human disease.
Craighead, J. E., Huber, S. A., & Sriram, S. (1990) · PubMed · Cited by 44 · see citing works
Epidemiologic, Pathogenic, and Molecular Analysis of Recent Encephalomyocarditis Outbreaks in Belgium
Koenen, F., Vanderhallen, H., Castryck, F., & Miry, C. (1999) · Journal of Veterinary Medicine Series B · doi:10.1111/j.0931-1793.1999.0_216.x · Cited by 40 · see citing works
Depletion of Mac1-positive macrophages protects DBA/2 mice from encephalomyocarditis virus-induced myocarditis and diabetes
Hirasawa, K., Tsutsui, S., Takeda, M., et al. (1996) · Journal of General Virology · doi:10.1099/0022-1317-77-4-737 · Cited by 38 · see citing works
Pathogenesis of Experimental Encephalomyocarditis: A Histopathological, Immunohistochemical and Virological Study in Mice
Psalla, D., Psychas, V., Spyrou, V., Billinis, C., Papaioannou, N., & Vlemmas, I. (2006) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2006.04.003 · Cited by 37 · see citing works
Pathological changes associated with equine arteritis virus infection of the reproductive tract in prepubertal and peripubertal colts
Holyoak, G. R., Giles, R. C., McCollum, W. H., et al. (1993) · Journal of Comparative Pathology · doi:10.1016/s0021-9975(08)80253-8 · Cited by 37 · see citing works
Amino acid differences in capsid protein, VP1, between diabetogenic and nondiabetogenic variants of encephalomyocarditis virus
Eun, H., Bae, Y., & Yoon, J.-W. (1988) · Virology · doi:10.1016/0042-6822(88)90277-2 · Cited by 37 · see citing works
Encephalomyocarditis of swine in Greece.
Paschaleri-Papadopoulou, E., Axiotis, I., & Laspidis, C. (1990) · PubMed · Cited by 36 · see citing works
Pathology of the testis in acquired immunodeficiency syndrome
ROGERS, C., & Klatt, E. C. (1988) · Histopathology · doi:10.1111/j.1365-2559.1988.tb01990.x · Cited by 36 · see citing works
The relationship between viral RNA, myelin-specific mRNAs, and demyelination in central nervous system disease during Theiler's virus infection.
Yamada, M., Zurbriggen, A., & Fujinami, R. S. (1990) · PubMed · Cited by 34 · see citing works
Encephalomyocarditis virus infection of captive elephants
Simpson, C. F., Lewis, A. L., & Gaskin, J. M. (1977) · Journal of the American Veterinary Medical Association · doi:10.2460/javma.1977.171.09.902 · Cited by 33 · see citing works
Pathogenic properties of encephalomyocarditis virus isolates in swine fetuses
Kim, H. S., Christianson, W. T., & Joo, H. (1989) · Archives of Virology · doi:10.1007/bf01310517 · Cited by 28 · see citing works
Enhanced Production of Macrophage Inflammatory Protein 2 (MIP-2) by In Vitro and In Vivo Infections with Encephalomyocarditis Virus and Modulation of Myocarditis with an Antibody against MIP-2
Kishimoto, C., Kawamata, H., Sakai, S., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.3.1294-1300.2001 · Cited by 28 · see citing works
Encephalomyocarditis Virus Induces PKR-Independent Mitogen-Activated Protein Kinase Activation in Macrophages
Moran, J. M., Moxley, M. A., Buller, R. M. L., et al. (2005) · Journal of Virology · doi:10.1128/jvi.79.16.10226-10236.2005 · Cited by 28 · see citing works
Experimental Encephalomyocarditis Virus Infection in Mongolian Gerbils (Meriones unguiculatus)
Matsuzaki, H., Doi, K., MITSUOKA, T., et al. (1989) · Veterinary Pathology · doi:10.1177/030098588902600103 · Cited by 28 · see citing works
Self-citation
A comparative study of the pathogenic properties and transmissibility of a Greek and a Belgian encephalomyocarditis virus (EMCV) for piglets
Billinis, C., Paschaleri-Papadopoulou, E., Anastasiadis, G., Psychas, V., Vlemmas, J., Leontides, S., Koumbati, M., Kyriakis, S. C., & Papadopoulos, O. (1999) · Veterinary Microbiology · doi:10.1016/s0378-1135(99)00145-5 · Cited by 27 · see citing works
Immunoglobulin Treatment Prevents Congestive Heart Failure in Murine Encephalomyocarditis Viral Myocarditis Associated with Reduction of Inflammatory Cytokines
Kishimoto, C., Takada, H., Kawamata, H., et al. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29273-9 · Cited by 27 · see citing works
Cellular prion protein prevents brain damage after encephalomyocarditis virus infection in mice
Nasu‐Nishimura, Y., Taniuchi, Y., Nishimura, T., et al. (2008) · Archives of Virology · doi:10.1007/s00705-008-0086-x · Cited by 26 · see citing works
A genetically determined host factor controlling susceptibility to encephalomyocarditis virus-induced diabetes in mice
KANG, Y. Y., & Yoon, J. W. (1993) · Journal of General Virology · doi:10.1099/0022-1317-74-6-1207 · Cited by 26 · see citing works
Treatment of encephalomyocarditis virus-induced central nervous system demyelination with monoclonal anti-T-cell antibodies
Sriram, S., Topham, D., Huang, S.-K., & Rodriguez, M. (1989) · Journal of Virology · doi:10.1128/jvi.63.10.4242-4248.1989 · Cited by 25 · see citing works
Apoptosis in congestive heart failure induced by viral myocarditis in mice
Yamada, T., Matsumori, A., Wang, W. Z., Ohashi, N., Shiota, K., & Sasayama, S. (1999) · Heart and Vessels · doi:10.1007/bf02481740 · Cited by 23 · see citing works
Susceptibility of Four Species of Small Rodents to Encephalomyocarditis (EMC) Virus Infection
Matsuzaki, H., Doi, K., Doi, C., et al. (1989) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim1978.38.4_357 · Cited by 23 · see citing works
Self-citation
Role of Hck in the Pathogenesis of Encephalomyocarditis Virus-Induced Diabetes in Mice
Choi, K. S., Jun, H., Kim, H. N., et al. (2001) · Journal of Virology · doi:10.1128/jvi.75.4.1949-1957.2001 · Cited by 21 · see citing works
Autoantibodies Against Vimentin in a Murine Model of Myocarditis
Satō, Y., Matsumori, A., & Sasayama, S. (1994) · Autoimmunity · doi:10.3109/08916939409007988 · Cited by 21 · see citing works
Pathogenesis of Experimental Encephalomyocarditis: a Histopathological, Immunohistochemical and Virological Study in Rats
Psalla, D., Psychas, V., Spyrou, V., Billinis, C., Papaioannou, N., & Vlemmas, I. (2005) · Journal of Comparative Pathology · doi:10.1016/j.jcpa.2005.06.008 · Cited by 21 · see citing works
Distribution of viral RNA in the spinal cord of DBA/2 mice developing biphasic paralysis following infection with the D variant of encephalomyocarditis virus (EMC-D).
Takeda, M., Miura, R., Shiota, K., et al. (1995) · PubMed · Cited by 20 · see citing works
Encephalomyocarditis virus infection and pig disease in Queensland
Hill, B. D., Ketterer, P. J., Rodwell, B. J., et al. (1985) · Australian Veterinary Journal · doi:10.1111/j.1751-0813.1985.tb14138.x · Cited by 20 · see citing works
Histopathology of BALB/c mice infected with the D variant of encephalomyocarditis virus.
Doi, K., Onodera, T., Tsuda, T., et al. (1988) · PubMed · Cited by 20 · see citing works
Self-citation
Immunomodulation of encephalomyocarditis virus-induced disease in A/J mice
Barger, M. T., & Craighead, J. E. (1991) · Journal of Virology · doi:10.1128/jvi.65.5.2676-2681.1991 · Cited by 19 · see citing works
Necrosis of the Pancreas, Parotid and Lachrymal Glands Associated with Encephalomyocarditis Virus Infection
Craighead, J. E. (1965) · Nature · doi:10.1038/2071268a0 · Cited by 19 · see citing works
In vivo administration of serum thymic factor (FTS) prevents EMC-D virus-induced diabetes and myocarditis in BALB/cAJcl mice
Mizutani, M., EL-FOTOH, M. D. M. E.-F. A. A., Mori, M., et al. (1996) · Archives of Virology · doi:10.1007/bf01718589 · Cited by 19 · see citing works
Lesions in the Central Nervous System of DBA/2 Mice Infected with the D Variant of Encephalomyocarditis Virus(EMC-D).
TAKEDA, M., Hirasawa, K., & Kunio, D. O. I. (1991) · Journal of Veterinary Medical Science · doi:10.1292/jvms.53.1013 · Cited by 18 · see citing works
Self-citation
Encephalomyocarditis (EMC) virus-induced orchitis in Syrian hamsters.
Hirasawa, K., Takeda, M., Matsuzaki, H., et al. (1991) · PubMed · Cited by 18 · see citing works
Molecular Identification of Diabetogenic Viral Gene
Bae, Y., Eun, H., & Yoon, J. (1989) · Diabetes · doi:10.2337/diab.38.3.316 · Cited by 17 · see citing works
Direct involvement of macrophages in destruction of beta-cells leading to development of diabetes in virus-infected mice
Baek, H. S., & Yoon, J. W. (1991) · Diabetes · doi:10.2337/diabetes.40.12.1586 · Cited by 17 · see citing works
Relation between distribution of viral RNA and development of histopathological changes in encephalomyocarditis virus‐induced orchitis in mice
Ueno, A., Takeda, M., HIRASAWA, K., et al. (1996) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1996.959097.x · Cited by 17 · see citing works
Increased severity of viral myocarditis in mice lacking lymphocyte maturation
Kanda, T., Koike, H., Arai, M., Wilson, J. E., Carthy, C. M., Yang, D., McManus, B. M., Nagai, R., & Kobayashi, I. (1999) · International Journal of Cardiology · doi:10.1016/s0167-5273(98)00250-2 · Cited by 16 · see citing works
An age‐related change in susceptibility of rat brain to encephalomyocarditis virus infection
Ikegami, H., TAKEDA, M., & Doi, K. (1997) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1997.d01-245.x · Cited by 16 · see citing works
Self-citation
Experimental inoculation of the adult rat testis with Sendai virus: effect on testicular morphology and leukocyte population
Melaine, N. (2003) · Human Reproduction · doi:10.1093/humrep/deg323 · Cited by 16 · see citing works
Involvement of Macrophages in the Development of Encephalomyocarditis(EMC) Virus-Induced Diabetes in Mice.
HIRASAWA, K., TAKEDA, M., ITAGAKI, S.-I., & Doi, K. (1996) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.45.77 · Cited by 15 · see citing works
Self-citation
D Variant of Encephalomyocarditis Virus (EMCV-D)-Induced Diabetes Following Natural Killer Cell Depletion in Diabetes-Resistant Male C57BL/6J Mice
WHITE, L. L., & SMITH, R. A. (1990) · Viral Immunology · doi:10.1089/vim.1990.3.67 · Cited by 15 · see citing works
Cardiac and pancreatic lesions in guinea pigs infected with encephalomyocarditis (EMC) virus.
Ma, P., Hirasawa, K., Takeda, M., et al. (1991) · PubMed · Cited by 14 · see citing works
T cell-mediated immune response enhances the severity of myocarditis in secondary cardiotropic virus infection in mice
Kishimoto, C., Hiraoka, Y., & Takada, H. (2001) · Basic Research in Cardiology · doi:10.1007/s003950170025 · Cited by 14 · see citing works
Viral myocarditis. Immunopathogenesis and the effect of immunosuppressive treatment in a murine model.
Matsumori, A., Tomioka, N., & KAWAI, C. (1989) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.53.58 · Cited by 14 · see citing works
Pathogenesis of Fatal Encephalomyocarditis (EMC) Virus Infections in Albino Rats
Kilham, L., Mason, P., & Davies, J. N. P. (1955) · Experimental Biology and Medicine · doi:10.3181/00379727-90-22041 · Cited by 13 · see citing works
Biphasic disease of central nervous system induced in DBA/2 mice by the D variant of encephalomyocarditis virus (EMC-D).
Takeda, M., ITAGAKI, S., & Doi, K. (1993) · PubMed · Cited by 13 · see citing works
Self-citation
Encephalomyocarditis(EMC) Virus-Induced Myocarditis by Different Virus Variants and Mouse Strains.
Hirasawa, K., Han, J.-S., TAKEDA, M., et al. (1992) · Journal of Veterinary Medical Science · doi:10.1292/jvms.54.1125 · Cited by 13 · see citing works
Indirect role of T cells in development of polioencephalitis and encephalomyelitis induced by encephalomyocarditis virus
Topham, D. J., Adesina, A. M., Shenoy, M., et al. (1991) · Journal of Virology · doi:10.1128/jvi.65.6.3238-3245.1991 · Cited by 13 · see citing works
Pathogenesis of the B variant of encephalomyocarditis virus
Shafi, R., CERUTIS, D. R., & GIRON, D. J. (1993) · Journal of Medical Virology · doi:10.1002/jmv.1890400305 · Cited by 13 · see citing works
Evaluation of ultrastructural changes associated with encephalomyocarditis virus in the myocardium of experimentally infected piglets
Psychas, V., Papaioannou, N., Billinis, C., et al. (2001) · American Journal of Veterinary Research · doi:10.2460/ajvr.2001.62.1653 · Cited by 11 · see citing works
Impaired Cytokine Response in Male ICR Swiss Mice After Infection With D Variant of Encephalomyocarditis Virus
Bigley, N. J., Blay, R., & Smith, R. A. (1987) · Diabetes · doi:10.2337/diab.36.12.1408 · Cited by 11 · see citing works
Encepalomyocarditis virus-induced apoptosis and ultrastructural changes in the lacrimal and parotid glands of mice
Ohguchi, A., Nakayama, Y., Yasoshima, A., et al. (2005) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2005.06.003 · Cited by 10 · see citing works
Experimental encephalomyocarditis virus infection in pregnant mice
Nakayama, Y., Su, W., Ohguchi, A., et al. (2004) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2004.02.003 · Cited by 10 · see citing works
Characteristics of testicular lesions in mice infected with a low dose of encephalomyocarditis (EMC) virus
Yamanouchi-Ueno, A., Nakayama, Y., & Doi, K. (2004) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2003.12.008 · Cited by 10 · see citing works
Self-citation
Acute Infection of Encephalomyocarditis (EMC) Virus in Syrian Hamsters
Sugawara, Y., HIRASAWA, K., Takeda, M., et al. (1991) · Journal of Veterinary Medical Science · doi:10.1292/jvms.53.463 · Cited by 10 · see citing works
Characterization of the placental barrier to murine enterovirus infection
Abzug, M. J. (1995) · Placenta · doi:10.1016/0143-4004(95)90009-8 · Cited by 10 · see citing works
Variation in Serum Creatine Phosphokinase Activity as Indicated in Two-Phase EMC-D Virus-Induced Myocarditis.
MIZUTANI, M., HIRASAWA, K., TAKEDA, M., et al. (1996) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.45.333 · Cited by 9 · see citing works
Identification of trophoblastic giant cells as the initial principal target of early gestational murine enterovirus infection
Abzug, M. J. (1993) · Placenta · doi:10.1016/s0143-4004(05)80256-5 · Cited by 9 · see citing works
Early Development of Encephalomyocarditis (EMC) Virus-induced Orchitis in Syrian Hamsters
Shigesato, M., Takeda, M., Hirasawa, K., et al. (1995) · Veterinary Pathology · doi:10.1177/030098589503200212 · Cited by 9 · see citing works
Encephalomyocarditis (EMC) virus-induced testicular lesion in BALB/c mice
Shigesato, M., Hirasawa, K., Takeda, M., et al. (1994) · Laboratory Animals · doi:10.1258/002367794780745146 · Cited by 9 · see citing works
Head-to-head type auto-spermagglutination with IgA antibody to acrosome induced by Brucella canis infection.
Serikawa, T., KONDO, Y., Takada, H., et al. (1984) · The Japanese Journal of Veterinary Science · doi:10.1292/jvms1939.46.41 · Cited by 9 · see citing works
Pathological Observations on Natural Cases of Sialodacryoadenitis of Rats
Doi, K., Yasoshima, A., KOJIMA, A., et al. (1980) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim1978.29.4_419 · Cited by 9 · see citing works
Self-citation
Impaired cytokine response in male ICR Swiss mice after infection with D variant of encephalomyocarditis virus
Bigley, N. J., Blay, R. A., & Smith, R. A. (1987) · Diabetes · doi:10.2337/diabetes.36.12.1408 · Cited by 9 · see citing works
The Role of CD4+ T Cells in Biphasic Hind Limb Paralysis Induced by the D Variant of Encephalomyocarditis Virus (EMC-D) in DBA/2 Mice
TAKEDA, M., Ohtsuka, R., Nakayama, Y., et al. (2004) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.53.31 · Cited by 8 · see citing works
Protective effects of macrophage-derived interferon against encephalomyocarditis virus-induced diabetes mellitus in mice.
Hirasawa, K., Ogiso, Y., Takeda, M., et al. (1995) · PubMed · Cited by 8 · see citing works
Molecular identification of diabetogenic viral gene
Bae, Y. S., Eun, H., & Yoon, J. (1989) · Diabetes · doi:10.2337/diabetes.38.3.316 · Cited by 8 · see citing works
AGM1+ spleen cells contain gamma interferon (IFN-gamma) gene transcripts in the early, sex-dependent production of IFN-gamma after picornavirus infection
McFarland, H., & Bigley, N. J. (1990) · Journal of Virology · doi:10.1128/jvi.64.9.4407-4413.1990 · Cited by 7 · see citing works
Susceptibility of primary culture neurons from rats of different ages to encephalomyocarditis (EMC) virus infection
Su, W., Ikegami, H., Nakayama, Y., et al. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(03)00068-6 · Cited by 7 · see citing works
The susceptibility of rats to encephalomyocarditis viruses.
Findlay, G. M., & HOWARD, E. M. (1951) · PubMed · Cited by 7 · see citing works
Pathogenesis of Myocardial Injury in Myocarditis and Cardiomyopathy.
Matsumori, A., Okada, I., Yamada, T., et al. (1991) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.55.1132 · Cited by 6 · see citing works
Detection of Viral RNA by Electron Microscopic In situ Hybridization(ISH-EM) in The Germinal Epithelium of Mice Infected with Encephalomyocarditis(EMC) Virus.
Ueno, A., Takeda, M., Hirasawa, K., et al. (1997) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.46.79 · Cited by 6 · see citing works
Encephalomyocarditis (EMC) virus-induced sialodacryoadenitis in mice
Ohguchi, A., Nakayama, Y., Doi, C., et al. (2004) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2004.09.003 · Cited by 5 · see citing works
Age‐related changes in susceptibility of rat brain slice cultures including hippocampus to encephalomyocarditis virus
Su, W., Ueno‐Yamanouchi, A., Uetsuka, K., et al. (1999) · International Journal of Experimental Pathology · doi:10.1046/j.1365-2613.1999.00133.x · Cited by 5 · see citing works
Transmissibility of the D variant of encephalomyocarditis virus (EMC-D) in mice
Doi, C., Takeda, M., Hirasawa, K., et al. (1993) · Laboratory Animals · doi:10.1258/002367793780745480 · Cited by 3 · see citing works
ラットの唾液腺・唳腺炎: 自然感染例の病理学的観察
土井, 邦., 八十島, 昭., 小島, 明., et al. (1980) · Medical Entomology and Zoology · Cited by 3 · see citing works
Experimental infection of human leukocytes with parainfluenza 1 (6/94) virus
Bogen, C., Gilden, D. H., Wróblewska, Z., et al. (1977) · Infection and Immunity · doi:10.1128/iai.18.2.501-508.1977 · Cited by 2 · see citing works
The Susceptibility of Pregnant Mice to Encephalomyocarditis (EMC) Virus Infection on Different Days of Gestation.
Nakayama, Y., Weiping, S. U., Katayama, K., et al. (2004) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.53.165 · Cited by 1 · see citing works

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The encephalomyocarditis virus
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Kishimoto, M., Hang’ombe, B. M., Hall, W. W., Orba, Y., Sawa, H., & Sasaki, M. (2021) · Journal of General Virology · doi:10.1099/jgv.0.001564 · Cited by 15 · see citing works
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“Although the tissue tropism of EMCV in rodents in vivo has been well studied [11,13], little is known about the in vitro host range of contemporary EMCV field isolates, particularly regarding rodent species and cells of importance in allowing shedding into the environment (i.e., intestinal…”

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Authors: Doi, K.
Affiliations: Nippon Institute for Biological Science (JP)
Corresponding author: Doi, K.
ORCID: Doi, K.
Venue: Journal of Comparative Pathology
Publisher: Elsevier BV
Published: 2011-01
Volume: 144
Issue: 1
Pages: 25-40
ISSN: 0021-9975 (ISSN-L)
DOI: 10.1016/j.jcpa.2010.05.001
OpenAlex: W2040955198
Cited by: 26
References: 148
Citations by year: 2026: 1 · 2025: 1 · 2023: 3 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 4 · 2012: 2
FWCI: 0.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Comparative Pathology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
Keywords: encephalomyocarditis virus, cardiovirus, experimental infection, laboratory rodents, rats, pathogenesis, pathology, myocarditis, encephalomyelitis, type 1 diabetes, reservoir hosts, sows
MeSH terms: Animals, Brain, Diabetes Mellitus, Disease Models, Animal, Disease Reservoirs, Encephalomyelitis, Encephalomyocarditis virus, Gerbillinae, Guinea Pigs, Cricetinae, Humans, Male, Mesocricetus, Myocarditis, Orchitis, Sialadenitis, Cardiovirus Infections, Mice, Rats

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Experimental encephalomyocarditis virus infection in small laboratory rodents

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