The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
DNA strand exchange and selective DNA annealing promoted by the human immunodeficiency virus type 1 nucleocapsid protein
Open accessAbstract
Nucleocapsid protein (NC) of human immunodeficiency virus type 1 (HIV-1) was expressed in Escherichia coli and purified. The protein displayed a variety of activities on DNA structure, all reflecting an ability to promote transition between double-helical and single-stranded conformations. We found that, in addition to its previously described ability to accelerate renaturation of complementary DNA strands, the HIV-1 NC protein could substantially lower the melting temperature of duplex DNA and could promote strand exchange between double-stranded and single-stranded DNA molecules. Moreover, in the presence of HIV-1 NC, annealing of a single-stranded DNA molecule to a complementary DNA strand that would yield a more stable double-stranded product was favored over annealing to alternative complementary DNA strands that would form less stable duplex products (selective annealing). NC thus appears to lower the kinetic barrier so that double-strand <==> single-strand equilibrium is rapidly reached to favor the lowest free-energy nucleic acid conformation. This activity of NC may be important for correct folding of viral genomic RNA and may have practical applications.
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Cites
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Cited by
HIV-1 Gag proteins: diverse functions in the virus life cycle
Freed, E. O. (1998) · Virology · doi:10.1006/viro.1998.9398 · Cited by 717
Role of the DIS hairpin in replication of human immunodeficiency virus type 1
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Metadata
- Authors
- Tsuchihashi, Z., & Brown, P. O.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1994-09
- Volume
- 68
- Issue
- 9
- Pages
- 5863-5870
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1901653080
- Cited by
- 253
- References
- 47
- FWCI
- 5.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tsuchihashi, Z., & Brown, P. O. (1994). DNA strand exchange and selective DNA annealing promoted by the human immunodeficiency virus type 1 nucleocapsid protein. Journal of Virology. https://doi.org/10.1128/jvi.68.9.5863-5870.1994
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
