Attenuated Mengo virus: a new vector for live recombinant vaccines
Open accessAbstract
Several features make Mengo virus an excellent candidate for use as a vaccine vector. The virus has a wide host range, including rodents, pigs, monkeys, and most likely humans, and expresses its genome exclusively in the cytoplasm of the infected cell. Stable attenuated strains exist which are deleted for part of the 5' noncoding region of the genome. Here we report an attenuated Mengo virus recombinant, vLCMG4, that encodes an immunodominant cytotoxic T-lymphocyte epitope of the lymphocytic choriomeningitis virus (LCMV) nucleo-protein. vLCMG4 induced protective immunity against lethal LCMV infection after a single, low-dose immunization in BALB/c mice and elicited an LCMV-specific CD8+ cytotoxic T lymphocyte response. This demonstrates the potential of recombinant Mengo virus vaccines to confer protection against infectious diseases by the induction of cellular immune responses.
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The encephalomyocarditis virus
Carocci, M., & Bakkali-Kassimi, L. (2012) · Virulence · doi:10.4161/viru.20573 · Cited by 231 · see citing works
- Authors
- Altmeyer, R., Girard, M., van der Werf, S., Mimic, V, Seigneur, L., & Saron, M. F.
- Affiliations
- Institut Pasteur (FR)
- Unité de Virologie Moléculaire, Institut Pasteur, Paris, France.
- ORCID
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1995-05
- Volume
- 69
- Issue
- 5
- Pages
- 3193-3196
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- PMC
- PMC189023
- OpenAlex
- W2131203478
- Cited by
- 29
- References
- 30
- Citations by year
- 2022: 1 · 2016: 2 · 2015: 2 · 2012: 1
- FWCI
- 3.11
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Virology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Virology and Viral Diseases
- Life Sciences › Immunology and Microbiology › Virology › Poxvirus research and outbreaks
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Vectors
- Keywords
- mengovirus, recombinant virus, lymphocytic choriomeningitis virus, CTL epitopes, CD8+ T cell responses, cell-mediated immunity, protective immunity
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, DNA, Viral, Genetic Vectors, Humans, Lymphocytic Choriomeningitis, Lymphocytic choriomeningitis virus, Mengovirus, Mice, Inbred BALB C, Molecular Sequence Data, Recombination, Genetic, T-Lymphocytes, Cytotoxic, Vaccines, Attenuated, Vaccines, Synthetic, Viral Proteins, Viral Vaccines, Gene Deletion, DNA, Complementary, Mice
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